ENSG00000101782

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000339486 ENSG00000101782 HEK293_OSMI2_2hA HEK293_TMG_2hB RIOK3 protein_coding protein_coding 16.07626 5.272856 24.70792 0.6608766 0.5293871 2.226167 10.4601609 2.8490288 16.3085339 0.5305539 0.35249928 2.5129144 0.63175000 0.56503333 0.66016667 0.095133333 8.403929e-01 3.679092e-05 FALSE TRUE
ENST00000581220 ENSG00000101782 HEK293_OSMI2_2hA HEK293_TMG_2hB RIOK3 protein_coding retained_intron 16.07626 5.272856 24.70792 0.6608766 0.5293871 2.226167 0.5451657 1.0252028 0.5204602 0.4471244 0.06835008 -0.9645971 0.05913333 0.18156667 0.02120000 -0.160366667 3.679092e-05 3.679092e-05   FALSE
ENST00000581302 ENSG00000101782 HEK293_OSMI2_2hA HEK293_TMG_2hB RIOK3 protein_coding retained_intron 16.07626 5.272856 24.70792 0.6608766 0.5293871 2.226167 2.0764861 0.4663167 3.5257175 0.4663167 0.31072454 2.8920099 0.10359167 0.08783333 0.14306667 0.055233333 2.942774e-01 3.679092e-05 TRUE TRUE
ENST00000581339 ENSG00000101782 HEK293_OSMI2_2hA HEK293_TMG_2hB RIOK3 protein_coding retained_intron 16.07626 5.272856 24.70792 0.6608766 0.5293871 2.226167 0.5511884 0.3004158 0.5430892 0.3004158 0.06226560 0.8333098 0.06207917 0.04693333 0.02210000 -0.024833333 7.996175e-01 3.679092e-05 TRUE FALSE
MSTRG.15582.1 ENSG00000101782 HEK293_OSMI2_2hA HEK293_TMG_2hB RIOK3 protein_coding   16.07626 5.272856 24.70792 0.6608766 0.5293871 2.226167 1.1350877 0.3745838 1.9788364 0.3745838 0.09088338 2.3705548 0.08017500 0.07056667 0.08013333 0.009566667 4.075402e-01 3.679092e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000101782 E001 0.8899506 0.0133865564 3.101403e-01 4.525092e-01 18 23453259 23453286 28 + 0.251 0.000 -10.896
ENSG00000101782 E002 0.7427016 0.0155158799 4.098611e-01 5.534921e-01 18 23453287 23453287 1 + 0.218 0.000 -10.628
ENSG00000101782 E003 0.8942170 0.0131994250 3.102148e-01 4.525777e-01 18 23453288 23453291 4 + 0.251 0.000 -10.892
ENSG00000101782 E004 20.1692653 0.0010172575 6.468407e-05 3.543111e-04 18 23453292 23453307 16 + 1.244 0.825 -1.542
ENSG00000101782 E005 89.5874275 0.0039483817 5.230249e-08 5.617410e-07 18 23453308 23453502 195 + 1.859 1.593 -0.901
ENSG00000101782 E006 82.9196932 0.0005226003 1.519299e-05 9.683631e-05 18 23462964 23463079 116 + 1.814 1.660 -0.521
ENSG00000101782 E007 0.1515154 0.0429283535 1.000000e+00   18 23463080 23463319 240 + 0.053 0.000 -8.307
ENSG00000101782 E008 67.4324702 0.0003882319 2.083317e-02 5.323847e-02 18 23463967 23464014 48 + 1.712 1.667 -0.153
ENSG00000101782 E009 89.5448554 0.0003387027 3.142937e-02 7.474611e-02 18 23464015 23464112 98 + 1.827 1.809 -0.061
ENSG00000101782 E010 2.3573698 0.0065688745 2.184137e-01 3.484977e-01 18 23464113 23464205 93 + 0.471 0.258 -1.268
ENSG00000101782 E011 100.6758263 0.0088287152 1.533886e-02 4.125709e-02 18 23464206 23464313 108 + 1.885 1.813 -0.243
ENSG00000101782 E012 81.7542146 0.0004342281 4.597425e-03 1.481314e-02 18 23464519 23464555 37 + 1.794 1.731 -0.214
ENSG00000101782 E013 97.7971859 0.0003096988 2.448594e-05 1.488939e-04 18 23464556 23464628 73 + 1.881 1.756 -0.419
ENSG00000101782 E014 49.1316832 0.0004859071 1.619865e-02 4.316153e-02 18 23466133 23466134 2 + 1.582 1.503 -0.267
ENSG00000101782 E015 62.5797813 0.0004180703 2.996996e-02 7.190171e-02 18 23466135 23466168 34 + 1.678 1.636 -0.144
ENSG00000101782 E016 99.0762710 0.0003291786 4.615205e-06 3.312120e-05 18 23466169 23466276 108 + 1.888 1.744 -0.486
ENSG00000101782 E017 95.8645639 0.0032351326 8.050828e-03 2.390828e-02 18 23467399 23467526 128 + 1.865 1.803 -0.208
ENSG00000101782 E018 0.5954526 0.0183100547 5.588229e-01 6.870085e-01 18 23467527 23467577 51 + 0.182 0.000 -10.307
ENSG00000101782 E019 69.7370898 0.0005779011 1.453152e-02 3.943605e-02 18 23473429 23473483 55 + 1.728 1.675 -0.179
ENSG00000101782 E020 89.1528504 0.0008536298 1.915926e-03 6.964930e-03 18 23473484 23473626 143 + 1.837 1.762 -0.251
ENSG00000101782 E021 103.5921145 0.0003208663 1.015516e-01 1.928396e-01 18 23474948 23475107 160 + 1.887 1.902 0.052
ENSG00000101782 E022 88.0227014 0.0028282541 4.334650e-01 5.758800e-01 18 23477006 23477086 81 + 1.796 1.927 0.443
ENSG00000101782 E023 15.9827684 0.0537941882 7.674504e-01 8.496843e-01 18 23477087 23477178 92 + 1.092 1.153 0.219
ENSG00000101782 E024 53.5450770 0.0005843615 2.375989e-01 3.713711e-01 18 23477179 23477187 9 + 1.577 1.737 0.544
ENSG00000101782 E025 91.5382747 0.0003224739 4.175290e-01 5.608635e-01 18 23477188 23477268 81 + 1.812 1.940 0.431
ENSG00000101782 E026 6.5710350 0.0025118470 4.147302e-01 5.581362e-01 18 23479007 23479316 310 + 0.724 0.920 0.766
ENSG00000101782 E027 62.4367638 0.0003997476 9.832769e-01 9.936198e-01 18 23479317 23479325 9 + 1.655 1.744 0.301
ENSG00000101782 E028 116.2905997 0.0002402710 5.834642e-01 7.075815e-01 18 23479326 23479424 99 + 1.918 2.031 0.381
ENSG00000101782 E029 631.7927374 0.0119145483 1.358592e-08 1.633719e-07 18 23481172 23483140 1969 + 2.599 2.919 1.066
ENSG00000101782 E030 1.7755556 0.0087277347 5.644504e-04 2.400786e-03 18 23486108 23486603 496 + 0.182 0.825 3.445