ENSG00000101773

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327155 ENSG00000101773 HEK293_OSMI2_2hA HEK293_TMG_2hB RBBP8 protein_coding protein_coding 23.20563 8.491083 37.00477 0.7209824 1.465457 2.122383 11.3725242 2.4514558 21.5307448 0.40170155 1.8023388 3.1294844 0.4250000 0.2848667 0.580300000 0.29543333 1.573997e-06 9.671438e-11 FALSE TRUE
ENST00000399722 ENSG00000101773 HEK293_OSMI2_2hA HEK293_TMG_2hB RBBP8 protein_coding protein_coding 23.20563 8.491083 37.00477 0.7209824 1.465457 2.122383 0.8147054 0.4932366 0.3335803 0.07660862 0.3335803 -0.5505896 0.0634750 0.0605000 0.009733333 -0.05076667 9.577276e-02 9.671438e-11 FALSE TRUE
ENST00000583057 ENSG00000101773 HEK293_OSMI2_2hA HEK293_TMG_2hB RBBP8 protein_coding protein_coding 23.20563 8.491083 37.00477 0.7209824 1.465457 2.122383 2.1729411 3.0218997 1.9052261 0.79407195 0.9798055 -0.6627073 0.1565833 0.3506000 0.051666667 -0.29893333 2.233954e-01 9.671438e-11 FALSE TRUE
MSTRG.15575.10 ENSG00000101773 HEK293_OSMI2_2hA HEK293_TMG_2hB RBBP8 protein_coding   23.20563 8.491083 37.00477 0.7209824 1.465457 2.122383 5.7708260 2.2379949 8.2369931 0.54885403 0.5751619 1.8752295 0.2301042 0.2674333 0.223833333 -0.04360000 8.854939e-01 9.671438e-11 FALSE TRUE
MSTRG.15575.11 ENSG00000101773 HEK293_OSMI2_2hA HEK293_TMG_2hB RBBP8 protein_coding   23.20563 8.491083 37.00477 0.7209824 1.465457 2.122383 1.8926216 0.0000000 3.5364920 0.00000000 0.7083281 8.4702489 0.0505875 0.0000000 0.094900000 0.09490000 9.671438e-11 9.671438e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000101773 E001 0.0000000       18 22798261 22798487 227 +      
ENSG00000101773 E002 0.0000000       18 22911600 22911685 86 +      
ENSG00000101773 E003 0.0000000       18 22914121 22914122 2 +      
ENSG00000101773 E004 0.0000000       18 22914123 22914138 16 +      
ENSG00000101773 E005 0.0000000       18 22914139 22914306 168 +      
ENSG00000101773 E006 0.0000000       18 22915420 22915485 66 +      
ENSG00000101773 E007 0.0000000       18 22916941 22917026 86 +      
ENSG00000101773 E008 0.0000000       18 22929383 22929437 55 +      
ENSG00000101773 E009 1.8351830 0.0640103573 4.277326e-01 5.705695e-01 18 22933328 22933348 21 + 0.413 0.239 -1.112
ENSG00000101773 E010 72.7170583 0.0023242758 1.147788e-09 1.682620e-08 18 22933349 22933564 216 + 1.821 1.413 -1.390
ENSG00000101773 E011 0.0000000       18 22933826 22933840 15 +      
ENSG00000101773 E012 0.1817044 0.0414352666 8.205037e-02   18 22933841 22933858 18 + 0.000 0.239 14.140
ENSG00000101773 E013 2.0920165 0.0110646846 2.821684e-01 4.221462e-01 18 22933859 22933870 12 + 0.459 0.239 -1.361
ENSG00000101773 E014 3.0518969 0.0164910226 3.840499e-01 5.282453e-01 18 22933871 22933875 5 + 0.557 0.392 -0.828
ENSG00000101773 E015 8.8605393 0.0047415675 3.009616e-01 4.427383e-01 18 22933876 22933880 5 + 0.923 0.787 -0.525
ENSG00000101773 E016 47.7259045 0.0020839974 3.808322e-01 5.251141e-01 18 22933881 22934078 198 + 1.593 1.550 -0.149
ENSG00000101773 E017 29.9074705 0.0220435511 8.634833e-01 9.159463e-01 18 22934079 22934159 81 + 1.380 1.417 0.128
ENSG00000101773 E018 1.9187417 0.0084484006 4.912688e-01 6.285627e-01 18 22934160 22934264 105 + 0.362 0.505 0.755
ENSG00000101773 E019 0.1472490 0.0440686966 1.000000e+00   18 22934750 22934774 25 + 0.059 0.000 -9.737
ENSG00000101773 E020 192.3591445 0.0106896011 1.118976e-04 5.765363e-04 18 22936754 22936960 207 + 2.217 1.998 -0.734
ENSG00000101773 E021 0.4439371 0.0215790594 7.735597e-01 8.538883e-01 18 22937060 22937118 59 + 0.157 0.000 -11.322
ENSG00000101773 E022 0.2966881 0.0274424043 1.000000e+00   18 22946339 22946443 105 + 0.110 0.000 -10.737
ENSG00000101773 E023 98.5965685 0.0058861152 1.787932e-04 8.727158e-04 18 22946444 22946486 43 + 1.929 1.708 -0.745
ENSG00000101773 E024 127.6452343 0.0038343670 2.634312e-06 1.996729e-05 18 22949618 22949713 96 + 2.042 1.803 -0.802
ENSG00000101773 E025 0.4439371 0.0215790594 7.735597e-01 8.538883e-01 18 22949714 22950035 322 + 0.157 0.000 -11.322
ENSG00000101773 E026 80.9361786 0.0003093678 2.086618e-05 1.288767e-04 18 22968806 22968841 36 + 1.845 1.623 -0.751
ENSG00000101773 E027 102.4582675 0.0003118893 9.848475e-07 8.182099e-06 18 22968842 22968918 77 + 1.947 1.718 -0.772
ENSG00000101773 E028 68.6888200 0.0003926791 2.011681e-04 9.687765e-04 18 22975153 22975180 28 + 1.774 1.567 -0.704
ENSG00000101773 E029 73.4746468 0.0003546915 5.652249e-04 2.403595e-03 18 22975181 22975219 39 + 1.798 1.616 -0.617
ENSG00000101773 E030 1.0404339 0.0116050594 8.554249e-01 9.106044e-01 18 22977790 22977887 98 + 0.271 0.238 -0.247
ENSG00000101773 E031 159.1152713 0.0002318552 9.074798e-05 4.785640e-04 18 22982218 22982393 176 + 2.123 1.990 -0.446
ENSG00000101773 E032 133.5181425 0.0003099377 3.508382e-03 1.175066e-02 18 22984886 22984990 105 + 2.045 1.941 -0.348
ENSG00000101773 E033 105.5945079 0.0002695860 8.602268e-02 1.690270e-01 18 22989221 22989271 51 + 1.936 1.875 -0.205
ENSG00000101773 E034 93.9797449 0.0003029288 4.675387e-05 2.653023e-04 18 22989272 22989318 47 + 1.905 1.712 -0.650
ENSG00000101773 E035 143.9219598 0.0002387357 2.743039e-04 1.275178e-03 18 22990937 22991049 113 + 2.078 1.949 -0.435
ENSG00000101773 E036 405.2144885 0.0080202462 9.691609e-01 9.847181e-01 18 22992748 22993483 736 + 2.501 2.521 0.068
ENSG00000101773 E037 194.7723503 0.0001875930 2.539896e-01 3.906217e-01 18 22993484 22993639 156 + 2.178 2.231 0.177
ENSG00000101773 E038 174.9532189 0.0002433876 5.021085e-04 2.167649e-03 18 22993721 22993847 127 + 2.114 2.244 0.433
ENSG00000101773 E039 161.9707559 0.0062416469 1.156024e-02 3.249021e-02 18 22996374 22996462 89 + 2.076 2.223 0.490
ENSG00000101773 E040 197.8516140 0.0066526753 8.413870e-03 2.482192e-02 18 22997620 22997734 115 + 2.162 2.312 0.501
ENSG00000101773 E041 0.8083901 0.0172907079 3.306705e-02 7.794227e-02 18 23001571 23001585 15 + 0.110 0.504 2.923
ENSG00000101773 E042 220.1860265 0.0003608054 1.592644e-05 1.010556e-04 18 23001586 23001729 144 + 2.210 2.352 0.476
ENSG00000101773 E043 154.1257657 0.0002327627 6.749073e-05 3.680248e-04 18 23006363 23006432 70 + 2.053 2.206 0.511
ENSG00000101773 E044 0.4439371 0.0215790594 7.735597e-01 8.538883e-01 18 23016796 23016827 32 + 0.157 0.000 -11.322
ENSG00000101773 E045 174.0333193 0.0002347461 2.377898e-04 1.124191e-03 18 23016828 23016924 97 + 2.110 2.245 0.454
ENSG00000101773 E046 178.8545529 0.0067494595 1.170709e-05 7.658403e-05 18 23022129 23022270 142 + 2.097 2.331 0.784
ENSG00000101773 E047 160.3199592 0.0094308793 5.413093e-08 5.791198e-07 18 23026143 23026488 346 + 2.023 2.344 1.072