ENSG00000101752

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261537 ENSG00000101752 HEK293_OSMI2_2hA HEK293_TMG_2hB MIB1 protein_coding protein_coding 10.31988 2.094397 18.18788 0.1984051 0.1661334 3.112291 4.4613296 0.2801559 9.8948787 0.04501618 0.57938531 5.0932390 0.3345333 0.13206667 0.544733333 0.41266667 2.403879e-09 2.403879e-09 FALSE TRUE
ENST00000578646 ENSG00000101752 HEK293_OSMI2_2hA HEK293_TMG_2hB MIB1 protein_coding processed_transcript 10.31988 2.094397 18.18788 0.1984051 0.1661334 3.112291 0.3151174 0.1552128 0.1102484 0.08927579 0.11024840 -0.4583074 0.1133292 0.06793333 0.005966667 -0.06196667 2.337464e-01 2.403879e-09 FALSE TRUE
ENST00000695487 ENSG00000101752 HEK293_OSMI2_2hA HEK293_TMG_2hB MIB1 protein_coding retained_intron 10.31988 2.094397 18.18788 0.1984051 0.1661334 3.112291 0.4591675 1.0315849 0.2511356 0.35663817 0.04316927 -1.9959095 0.1651417 0.46823333 0.013800000 -0.45443333 2.226748e-08 2.403879e-09 FALSE FALSE
MSTRG.15558.4 ENSG00000101752 HEK293_OSMI2_2hA HEK293_TMG_2hB MIB1 protein_coding   10.31988 2.094397 18.18788 0.1984051 0.1661334 3.112291 4.6735038 0.6057353 7.0411065 0.26867420 0.52869736 3.5174676 0.3469583 0.32220000 0.386666667 0.06446667 7.718078e-01 2.403879e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000101752 E001 1.6575400 0.0084811811 8.012871e-04 3.264184e-03 18 21704957 21705123 167 + 0.126 0.946 4.534
ENSG00000101752 E002 45.7407320 0.0004498825 3.461035e-05 2.026401e-04 18 21740792 21741548 757 + 1.325 1.179 -0.516
ENSG00000101752 E003 46.7180352 0.0004500179 8.329587e-02 1.647284e-01 18 21741549 21741812 264 + 1.317 1.488 0.592
ENSG00000101752 E004 75.3942769 0.0003382561 1.147727e-10 2.005288e-09 18 21765772 21765943 172 + 1.539 1.222 -1.101
ENSG00000101752 E005 75.8097947 0.0003196203 3.161840e-07 2.911730e-06 18 21768623 21768752 130 + 1.536 1.416 -0.412
ENSG00000101752 E006 61.9127393 0.0003726487 4.895469e-04 2.120329e-03 18 21773624 21773728 105 + 1.444 1.465 0.074
ENSG00000101752 E007 52.4179054 0.0008497556 5.009864e-04 2.163742e-03 18 21778103 21778169 67 + 1.376 1.360 -0.055
ENSG00000101752 E008 104.0570119 0.0076255643 1.247589e-04 6.355940e-04 18 21779481 21779685 205 + 1.664 1.681 0.057
ENSG00000101752 E009 1.0371996 0.0182056919 6.735308e-01 7.791887e-01 18 21791335 21791373 39 + 0.168 0.000 -20.167
ENSG00000101752 E010 101.2952079 0.0120735503 1.205348e-05 7.859489e-05 18 21791374 21791557 184 + 1.656 1.571 -0.290
ENSG00000101752 E011 92.4590037 0.0041251628 2.308090e-06 1.771434e-05 18 21798084 21798228 145 + 1.617 1.550 -0.228
ENSG00000101752 E012 88.0460379 0.0003901564 5.432087e-07 4.771608e-06 18 21799841 21799974 134 + 1.596 1.530 -0.223
ENSG00000101752 E013 0.0000000       18 21803733 21803906 174 +      
ENSG00000101752 E014 70.3258492 0.0004460118 1.014483e-07 1.028748e-06 18 21803907 21804014 108 + 1.506 1.330 -0.608
ENSG00000101752 E015 2.5396684 0.0830716242 1.937565e-01 3.185058e-01 18 21808612 21808738 127 + 0.333 0.000 -21.451
ENSG00000101752 E016 1.8143566 0.0085904913 1.000000e+00 1.000000e+00 18 21812392 21812468 77 + 0.242 0.409 1.074
ENSG00000101752 E017 84.0421768 0.0010752209 4.685361e-07 4.168049e-06 18 21815616 21815813 198 + 1.578 1.488 -0.308
ENSG00000101752 E018 0.0000000       18 21819065 21819494 430 +      
ENSG00000101752 E019 71.8404688 0.0003395841 1.577689e-03 5.886412e-03 18 21819495 21819646 152 + 1.504 1.586 0.282
ENSG00000101752 E020 74.6916277 0.0003294936 1.108494e-05 7.290043e-05 18 21838365 21838497 133 + 1.526 1.488 -0.131
ENSG00000101752 E021 0.4460135 0.0293450339 1.000000e+00 1.000000e+00 18 21838498 21839853 1356 + 0.080 0.000 -18.945
ENSG00000101752 E022 74.4232571 0.0003575815 1.794283e-07 1.735711e-06 18 21843131 21843217 87 + 1.529 1.389 -0.481
ENSG00000101752 E023 98.7744331 0.0003263603 5.539164e-08 5.910657e-07 18 21844092 21844253 162 + 1.646 1.568 -0.262
ENSG00000101752 E024 93.1066258 0.0004878866 3.368207e-04 1.527644e-03 18 21846944 21847125 182 + 1.612 1.695 0.281
ENSG00000101752 E025 103.2872970 0.0002703155 1.060246e-04 5.497154e-04 18 21849196 21849388 193 + 1.657 1.734 0.261
ENSG00000101752 E026 4.1856714 0.0038410157 2.797898e-01 4.195618e-01 18 21852225 21853139 915 + 0.451 0.409 -0.221
ENSG00000101752 E027 80.6331206 0.0021423570 1.055515e-06 8.716831e-06 18 21853140 21853218 79 + 1.561 1.465 -0.329
ENSG00000101752 E028 96.7423349 0.0002995712 8.285797e-07 7.003611e-06 18 21857130 21857243 114 + 1.635 1.604 -0.105
ENSG00000101752 E029 92.3420495 0.0002846872 2.256822e-05 1.382219e-04 18 21858546 21858646 101 + 1.612 1.636 0.084
ENSG00000101752 E030 1481.7785446 0.0261530017 9.735870e-13 2.395365e-11 18 21864526 21870953 6428 + 2.751 3.341 1.960