ENSG00000101596

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000320876 ENSG00000101596 HEK293_OSMI2_2hA HEK293_TMG_2hB SMCHD1 protein_coding protein_coding 9.67578 2.110711 15.75031 0.1681158 0.4657641 2.893676 5.4986065 0.2774505 10.78605433 0.10526179 0.49136559 5.2310465 0.41100417 0.13940000 0.687900000 0.5485000000 0.0001066467 0.0001066467 FALSE TRUE
ENST00000581631 ENSG00000101596 HEK293_OSMI2_2hA HEK293_TMG_2hB SMCHD1 protein_coding retained_intron 9.67578 2.110711 15.75031 0.1681158 0.4657641 2.893676 0.8401824 0.0369809 0.58817974 0.03698090 0.58817974 3.6704328 0.05082917 0.02053333 0.035800000 0.0152666667 0.8231188278 0.0001066467 FALSE FALSE
ENST00000583800 ENSG00000101596 HEK293_OSMI2_2hA HEK293_TMG_2hB SMCHD1 protein_coding processed_transcript 9.67578 2.110711 15.75031 0.1681158 0.4657641 2.893676 0.6643354 0.1054108 0.72479449 0.07050113 0.11932292 2.6705626 0.07081667 0.04543333 0.046066667 0.0006333333 0.9961678566 0.0001066467   FALSE
ENST00000642953 ENSG00000101596 HEK293_OSMI2_2hA HEK293_TMG_2hB SMCHD1 protein_coding nonsense_mediated_decay 9.67578 2.110711 15.75031 0.1681158 0.4657641 2.893676 0.1674101 0.3975580 0.08191812 0.39755803 0.06183068 -2.1485843 0.05930833 0.18480000 0.005433333 -0.1793666667 0.8393354734 0.0001066467 TRUE TRUE
ENST00000645355 ENSG00000101596 HEK293_OSMI2_2hA HEK293_TMG_2hB SMCHD1 protein_coding nonsense_mediated_decay 9.67578 2.110711 15.75031 0.1681158 0.4657641 2.893676 0.1395033 0.3929794 0.00000000 0.21331756 0.00000000 -5.3326343 0.06725417 0.18520000 0.000000000 -0.1852000000 0.0377608044 0.0001066467 FALSE TRUE
ENST00000686763 ENSG00000101596 HEK293_OSMI2_2hA HEK293_TMG_2hB SMCHD1 protein_coding nonsense_mediated_decay 9.67578 2.110711 15.75031 0.1681158 0.4657641 2.893676 0.8218131 0.6119692 0.83189291 0.08239496 0.49253496 0.4367936 0.16150417 0.29290000 0.051633333 -0.2412666667 0.1669933675 0.0001066467 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000101596 E001 8.5735219 0.0019573575 4.195758e-03 1.369315e-02 18 2655726 2655918 193 + 0.769 0.000 -15.362
ENSG00000101596 E002 8.1443465 0.0039477346 5.596172e-03 1.754477e-02 18 2655919 2655987 69 + 0.750 0.000 -15.268
ENSG00000101596 E003 13.0767585 0.0213836369 6.717855e-03 2.048839e-02 18 2655988 2656124 137 + 0.920 0.354 -2.536
ENSG00000101596 E004 22.4107235 0.0011417642 2.436996e-02 6.058178e-02 18 2656125 2656261 137 + 1.120 0.864 -0.950
ENSG00000101596 E005 23.0719532 0.0008024402 5.042963e-02 1.099344e-01 18 2666157 2666232 76 + 1.128 0.933 -0.717
ENSG00000101596 E006 54.0688019 0.0006226141 1.532444e-05 9.759210e-05 18 2666870 2667031 162 + 1.488 1.092 -1.390
ENSG00000101596 E007 45.0766475 0.0004584189 4.312607e-04 1.894561e-03 18 2673281 2673363 83 + 1.410 1.092 -1.122
ENSG00000101596 E008 49.5369841 0.0004568303 6.956207e-04 2.883029e-03 18 2674015 2674145 131 + 1.448 1.172 -0.964
ENSG00000101596 E009 43.2465561 0.0027139572 2.845701e-03 9.811447e-03 18 2688394 2688508 115 + 1.391 1.134 -0.904
ENSG00000101596 E010 22.6712792 0.0077201440 1.405681e-01 2.488149e-01 18 2688628 2688640 13 + 1.120 0.993 -0.463
ENSG00000101596 E011 29.6495734 0.0218186595 1.266202e-01 2.294387e-01 18 2688641 2688692 52 + 1.229 1.092 -0.486
ENSG00000101596 E012 27.0570664 0.0078065321 1.706893e-02 4.508976e-02 18 2688693 2688747 55 + 1.198 0.933 -0.965
ENSG00000101596 E013 0.1472490 0.0438636255 5.023248e-01   18 2690666 2690761 96 + 0.035 0.000 -9.486
ENSG00000101596 E014 50.0496280 0.0015620592 8.217785e-05 4.382734e-04 18 2694527 2694693 167 + 1.456 1.092 -1.280
ENSG00000101596 E015 46.5478260 0.0004684495 1.967822e-03 7.125345e-03 18 2697032 2697122 91 + 1.420 1.172 -0.866
ENSG00000101596 E016 0.0000000       18 2697123 2697216 94 +      
ENSG00000101596 E017 60.4503286 0.0003708002 3.363226e-04 1.525677e-03 18 2697831 2698041 211 + 1.528 1.271 -0.892
ENSG00000101596 E018 36.1150223 0.0006899843 2.444585e-02 6.074253e-02 18 2700539 2700659 121 + 1.308 1.134 -0.615
ENSG00000101596 E019 31.0982429 0.0008093385 4.877006e-02 1.069752e-01 18 2700735 2700776 42 + 1.246 1.092 -0.551
ENSG00000101596 E020 43.2703396 0.0009702062 2.921915e-02 7.042955e-02 18 2700777 2700858 82 + 1.381 1.241 -0.489
ENSG00000101596 E021 38.5099413 0.0144527712 8.195533e-02 1.626186e-01 18 2700859 2700918 60 + 1.331 1.211 -0.419
ENSG00000101596 E022 0.1451727 0.0430220064 5.013333e-01   18 2700919 2701255 337 + 0.035 0.000 -9.486
ENSG00000101596 E023 0.0000000       18 2702217 2702292 76 +      
ENSG00000101596 E024 20.6751431 0.0009272188 1.123713e-01 2.089988e-01 18 2703692 2703693 2 + 1.079 0.933 -0.540
ENSG00000101596 E025 51.9829204 0.0004841839 8.922436e-04 3.587057e-03 18 2703694 2703886 193 + 1.465 1.208 -0.895
ENSG00000101596 E026 44.7275626 0.0006081844 1.113514e-05 7.319843e-05 18 2705694 2705807 114 + 1.411 0.933 -1.712
ENSG00000101596 E027 0.4375944 0.0260801947 1.000000e+00 1.000000e+00 18 2705808 2706363 556 + 0.098 0.000 -11.071
ENSG00000101596 E028 38.7987441 0.0005446044 3.875707e-03 1.279411e-02 18 2706364 2706442 79 + 1.346 1.091 -0.900
ENSG00000101596 E029 24.2015088 0.0020256581 1.261248e-02 3.499716e-02 18 2706443 2706470 28 + 1.154 0.864 -1.074
ENSG00000101596 E030 1.3296214 0.0207257542 5.556043e-01 6.844507e-01 18 2706471 2707228 758 + 0.245 0.000 -12.656
ENSG00000101596 E031 0.5202097 0.0206464298 1.633174e-01 2.794991e-01 18 2707444 2707562 119 + 0.067 0.355 2.910
ENSG00000101596 E032 30.8606796 0.0007897256 8.791779e-04 3.541067e-03 18 2707563 2707645 83 + 1.256 0.864 -1.436
ENSG00000101596 E033 31.0047170 0.0007301415 4.654054e-02 1.030162e-01 18 2707807 2707920 114 + 1.248 1.092 -0.559
ENSG00000101596 E034 27.9228571 0.0008036863 2.449482e-02 6.083950e-02 18 2718158 2718211 54 + 1.207 0.992 -0.777
ENSG00000101596 E035 27.1820044 0.0007066256 3.097988e-02 7.387573e-02 18 2718212 2718235 24 + 1.196 0.992 -0.736
ENSG00000101596 E036 43.9155092 0.0005005413 4.258941e-02 9.579850e-02 18 2718315 2718434 120 + 1.388 1.271 -0.409
ENSG00000101596 E037 34.2089740 0.0005937152 4.053891e-02 9.200660e-02 18 2722519 2722603 85 + 1.286 1.134 -0.538
ENSG00000101596 E038 30.5586284 0.0006576000 1.104834e-01 2.062412e-01 18 2722604 2722663 60 + 1.236 1.134 -0.363
ENSG00000101596 E039 19.0246738 0.0009323047 2.968542e-02 7.134376e-02 18 2724899 2724901 3 + 1.054 0.781 -1.035
ENSG00000101596 E040 35.7148925 0.0005905430 1.190042e-02 3.329443e-02 18 2724902 2724995 94 + 1.306 1.092 -0.761
ENSG00000101596 E041 31.1965635 0.0006165230 1.690890e-01 2.870042e-01 18 2726452 2726524 73 + 1.242 1.172 -0.247
ENSG00000101596 E042 6.7112810 0.0242721675 3.937949e-01 5.377005e-01 18 2726525 2727163 639 + 0.664 0.546 -0.521
ENSG00000101596 E043 0.7300161 0.0552991091 1.000000e+00 1.000000e+00 18 2728371 2728413 43 + 0.152 0.000 -11.807
ENSG00000101596 E044 1.2062186 0.1378779806 6.292386e-01 7.446458e-01 18 2728414 2728456 43 + 0.200 0.355 1.107
ENSG00000101596 E045 26.4772309 0.0007488298 8.820236e-02 1.723855e-01 18 2728457 2728483 27 + 1.179 1.045 -0.484
ENSG00000101596 E046 43.3806646 0.0007451986 2.575323e-02 6.343201e-02 18 2728484 2728596 113 + 1.385 1.240 -0.505
ENSG00000101596 E047 0.2214452 0.0368885226 2.115126e-02   18 2728597 2728830 234 + 0.000 0.355 17.030
ENSG00000101596 E048 55.6699943 0.0004312162 1.431660e-02 3.895101e-02 18 2729275 2729409 135 + 1.488 1.351 -0.472
ENSG00000101596 E049 62.5145926 0.0003838585 2.704748e-02 6.609051e-02 18 2732265 2732454 190 + 1.536 1.439 -0.333
ENSG00000101596 E050 29.2851721 0.0024455294 1.487972e-01 2.600461e-01 18 2732455 2732492 38 + 1.221 1.134 -0.310
ENSG00000101596 E051 1.0445865 0.1061127179 5.467772e-01 6.768858e-01 18 2736465 2738396 1932 + 0.178 0.353 1.311
ENSG00000101596 E052 56.9688479 0.0004309559 9.010441e-02 1.752954e-01 18 2738397 2738545 149 + 1.494 1.439 -0.188
ENSG00000101596 E053 50.4974376 0.0005186844 8.812004e-02 1.722655e-01 18 2739432 2739520 89 + 1.441 1.375 -0.230
ENSG00000101596 E054 60.4271782 0.0003872069 2.446683e-01 3.796549e-01 18 2740703 2740821 119 + 1.513 1.512 -0.003
ENSG00000101596 E055 77.5357051 0.0005910709 4.180821e-01 5.613711e-01 18 2743761 2743928 168 + 1.616 1.655 0.131
ENSG00000101596 E056 62.1579892 0.0004557222 3.001131e-02 7.198268e-02 18 2747522 2747647 126 + 1.533 1.439 -0.322
ENSG00000101596 E057 48.3789875 0.0018266514 2.928886e-01 4.339098e-01 18 2750043 2750122 80 + 1.422 1.419 -0.013
ENSG00000101596 E058 42.1605727 0.0005406051 5.436225e-01 6.742059e-01 18 2750350 2750429 80 + 1.360 1.397 0.128
ENSG00000101596 E059 42.0108345 0.0005202635 7.196057e-01 8.143837e-01 18 2750430 2750507 78 + 1.357 1.419 0.213
ENSG00000101596 E060 41.7023142 0.0005270557 7.591275e-01 8.435358e-01 18 2751278 2751393 116 + 1.352 1.419 0.230
ENSG00000101596 E061 38.3462140 0.0005534292 7.080723e-01 8.057893e-01 18 2752488 2752552 65 + 1.317 1.375 0.202
ENSG00000101596 E062 0.1515154 0.0430331178 5.019966e-01   18 2752553 2754748 2196 + 0.035 0.000 -9.487
ENSG00000101596 E063 0.1472490 0.0438636255 5.023248e-01   18 2756621 2756901 281 + 0.035 0.000 -9.486
ENSG00000101596 E064 0.0000000       18 2759606 2759685 80 +      
ENSG00000101596 E065 0.0000000       18 2759686 2759758 73 +      
ENSG00000101596 E066 0.0000000       18 2759759 2759764 6 +      
ENSG00000101596 E067 0.0000000       18 2759765 2760400 636 +      
ENSG00000101596 E068 0.0000000       18 2760401 2760651 251 +      
ENSG00000101596 E069 46.3831861 0.0013139497 8.716203e-01 9.214200e-01 18 2760652 2760739 88 + 1.395 1.477 0.283
ENSG00000101596 E070 64.1271219 0.0075675812 7.498156e-01 8.366531e-01 18 2762105 2762236 132 + 1.528 1.656 0.435
ENSG00000101596 E071 1.6638853 0.0081860535 2.646230e-01 4.025893e-01 18 2762237 2763636 1400 + 0.245 0.547 1.737
ENSG00000101596 E072 65.6421164 0.0029226291 5.593708e-01 6.874903e-01 18 2763637 2763789 153 + 1.535 1.679 0.490
ENSG00000101596 E073 0.0000000       18 2763876 2763969 94 +      
ENSG00000101596 E074 0.1472490 0.0438636255 5.023248e-01   18 2764034 2764068 35 + 0.035 0.000 -9.486
ENSG00000101596 E075 0.1472490 0.0438636255 5.023248e-01   18 2764069 2764106 38 + 0.035 0.000 -9.486
ENSG00000101596 E076 65.7952145 0.0004276879 3.406530e-01 4.846041e-01 18 2769694 2769820 127 + 1.534 1.701 0.568
ENSG00000101596 E077 61.3308409 0.0004126962 9.290870e-01 9.594033e-01 18 2769989 2770108 120 + 1.513 1.603 0.308
ENSG00000101596 E078 56.8552735 0.0004258296 9.557513e-02 1.837563e-01 18 2771533 2771618 86 + 1.467 1.689 0.759
ENSG00000101596 E079 0.0000000       18 2771619 2771785 167 +      
ENSG00000101596 E080 50.2187881 0.0004534071 5.035892e-01 6.395749e-01 18 2772250 2772295 46 + 1.422 1.575 0.523
ENSG00000101596 E081 60.6779897 0.0004084202 2.000793e-01 3.263572e-01 18 2772296 2772372 77 + 1.497 1.689 0.656
ENSG00000101596 E082 85.8945257 0.0003111353 1.534095e-01 2.663127e-01 18 2775734 2775924 191 + 1.644 1.832 0.636
ENSG00000101596 E083 74.0096105 0.0003714748 2.992617e-01 4.407612e-01 18 2777806 2777915 110 + 1.583 1.752 0.573
ENSG00000101596 E084 0.1515154 0.0430331178 5.019966e-01   18 2777916 2778168 253 + 0.035 0.000 -9.487
ENSG00000101596 E085 61.3532867 0.0033575070 4.224700e-01 5.656071e-01 18 2778169 2778239 71 + 1.506 1.667 0.550
ENSG00000101596 E086 1.2973666 0.0102375075 1.381050e-01 2.454392e-01 18 2778240 2778940 701 + 0.177 0.547 2.324
ENSG00000101596 E087 1.0287806 0.0120980508 8.129092e-01 8.813781e-01 18 2778941 2780231 1291 + 0.201 0.000 -12.293
ENSG00000101596 E088 2.9675961 0.0093618385 2.807984e-01 4.206714e-01 18 2782786 2784449 1664 + 0.385 0.679 1.403
ENSG00000101596 E089 100.1102542 0.0039922320 2.030872e-01 3.300925e-01 18 2784450 2784621 172 + 1.710 1.893 0.619
ENSG00000101596 E090 0.2966881 0.0269463666 1.000000e+00   18 2784845 2784987 143 + 0.067 0.000 -10.486
ENSG00000101596 E091 89.6638215 0.0014725127 1.873093e-02 4.874474e-02 18 2795949 2796098 150 + 1.656 1.899 0.822
ENSG00000101596 E092 36.7494814 0.0022398470 4.370313e-04 1.916889e-03 18 2796099 2796107 9 + 1.259 1.655 1.366
ENSG00000101596 E093 79.1877891 0.0017824531 1.135952e-02 3.202660e-02 18 2796407 2796521 115 + 1.600 1.863 0.891
ENSG00000101596 E094 0.2966881 0.0269463666 1.000000e+00   18 2796768 2796860 93 + 0.067 0.000 -10.486
ENSG00000101596 E095 5.1108810 0.0199043657 8.199390e-01 8.863471e-01 18 2800523 2800740 218 + 0.557 0.679 0.537
ENSG00000101596 E096 5.7255892 0.0247536372 9.626479e-01 9.803983e-01 18 2800741 2801263 523 + 0.596 0.679 0.360
ENSG00000101596 E097 361.1656013 0.0863947754 1.839721e-04 8.948844e-04 18 2802528 2805017 2490 + 2.199 2.777 1.926