ENSG00000101574

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000574538 ENSG00000101574 HEK293_OSMI2_2hA HEK293_TMG_2hB METTL4 protein_coding protein_coding 5.207752 1.621598 8.284733 0.1220002 0.8181652 2.34591 1.3298546 0.6944931 2.432075 0.10069587 0.12050152 1.793450 0.30942917 0.4419000 0.29716667 -0.1447333 3.648243e-01 2.478061e-10 FALSE TRUE
ENST00000574676 ENSG00000101574 HEK293_OSMI2_2hA HEK293_TMG_2hB METTL4 protein_coding protein_coding 5.207752 1.621598 8.284733 0.1220002 0.8181652 2.34591 0.1330164 0.2556972 0.000000 0.25569717 0.00000000 -4.731711 0.05872917 0.1375667 0.00000000 -0.1375667 5.273973e-01 2.478061e-10   FALSE
ENST00000577166 ENSG00000101574 HEK293_OSMI2_2hA HEK293_TMG_2hB METTL4 protein_coding protein_coding 5.207752 1.621598 8.284733 0.1220002 0.8181652 2.34591 0.6689113 0.0000000 1.879570 0.00000000 0.06461214 7.561914 0.13538750 0.0000000 0.22973333 0.2297333 2.478061e-10 2.478061e-10   FALSE
ENST00000609769 ENSG00000101574 HEK293_OSMI2_2hA HEK293_TMG_2hB METTL4 protein_coding protein_coding 5.207752 1.621598 8.284733 0.1220002 0.8181652 2.34591 1.1150961 0.0000000 1.902301 0.00000000 0.52833376 7.579166 0.13570000 0.0000000 0.22213333 0.2221333 5.770240e-07 2.478061e-10 FALSE TRUE
MSTRG.15403.5 ENSG00000101574 HEK293_OSMI2_2hA HEK293_TMG_2hB METTL4 protein_coding   5.207752 1.621598 8.284733 0.1220002 0.8181652 2.34591 1.2020714 0.4192760 1.327106 0.09915173 0.30437094 1.639137 0.21557917 0.2699000 0.16856667 -0.1013333 5.912273e-01 2.478061e-10 FALSE TRUE
MSTRG.15403.7 ENSG00000101574 HEK293_OSMI2_2hA HEK293_TMG_2hB METTL4 protein_coding   5.207752 1.621598 8.284733 0.1220002 0.8181652 2.34591 0.4934909 0.2412228 0.596435 0.12272302 0.38622135 1.271386 0.07794167 0.1439333 0.06573333 -0.0782000 8.377083e-01 2.478061e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000101574 E001 0.0000000       18 2537525 2537529 5 -      
ENSG00000101574 E002 0.0000000       18 2537530 2537530 1 -      
ENSG00000101574 E003 18.1381634 0.0030990696 0.185149876 0.307671494 18 2537531 2538125 595 - 1.206 1.323 0.411
ENSG00000101574 E004 46.2753948 0.0113820701 0.393050506 0.536930928 18 2538126 2538753 628 - 1.605 1.675 0.237
ENSG00000101574 E005 19.5061376 0.0010285537 0.038329917 0.087968985 18 2538754 2538849 96 - 1.211 1.381 0.594
ENSG00000101574 E006 39.7545755 0.0007144416 0.042164690 0.095025922 18 2538850 2539145 296 - 1.525 1.644 0.408
ENSG00000101574 E007 17.3838532 0.0011489259 0.317582732 0.460477703 18 2544195 2544286 92 - 1.239 1.146 -0.330
ENSG00000101574 E008 20.1130573 0.0009503694 0.654468637 0.764640198 18 2544653 2544759 107 - 1.261 1.299 0.134
ENSG00000101574 E009 25.1505448 0.0009006728 0.930184572 0.960079525 18 2547355 2547529 175 - 1.363 1.370 0.024
ENSG00000101574 E010 0.4386386 0.1041680367 0.683629015 0.786775721 18 2549911 2549967 57 - 0.133 0.201 0.711
ENSG00000101574 E011 20.0606812 0.0013839079 0.205794288 0.333411688 18 2552695 2552764 70 - 1.243 1.347 0.365
ENSG00000101574 E012 3.3475528 0.0046963521 0.258205056 0.395419607 18 2552765 2554668 1904 - 0.644 0.443 -0.945
ENSG00000101574 E013 21.1574716 0.0023377777 0.847330711 0.905183074 18 2554669 2554785 117 - 1.301 1.285 -0.056
ENSG00000101574 E014 35.2179195 0.0005971032 0.001388223 0.005268113 18 2554786 2555038 253 - 1.560 1.336 -0.775
ENSG00000101574 E015 20.7713014 0.0020085232 0.108907044 0.203927025 18 2563797 2563859 63 - 1.324 1.181 -0.505
ENSG00000101574 E016 2.6593564 0.0057560906 0.003885143 0.012821907 18 2566694 2566820 127 - 0.626 0.001 -10.845
ENSG00000101574 E017 30.4888230 0.0033125170 0.002696849 0.009364184 18 2566821 2567006 186 - 1.501 1.258 -0.841
ENSG00000101574 E018 25.0367772 0.0008564458 0.031847406 0.075559118 18 2567007 2567153 147 - 1.405 1.229 -0.614
ENSG00000101574 E019 18.6815396 0.0012138927 0.009125197 0.026595893 18 2567154 2567356 203 - 1.297 1.043 -0.908
ENSG00000101574 E020 11.9981933 0.0015102657 0.995751895 1.000000000 18 2567357 2567511 155 - 1.064 1.065 0.006
ENSG00000101574 E021 30.1246112 0.0073685531 0.095132778 0.183074838 18 2567512 2567654 143 - 1.402 1.533 0.449
ENSG00000101574 E022 40.7191079 0.0011113908 0.006326730 0.019472640 18 2571149 2571509 361 - 1.520 1.678 0.538