ENSG00000101493

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000443185 ENSG00000101493 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF516 protein_coding protein_coding 3.079065 2.426036 2.991298 0.1482172 0.1343181 0.301051 1.5069802 1.4163322 1.1410589 0.15299146 0.06646918 -0.3093484 0.49982917 0.58043333 0.3845667 -0.19586667 0.03310113 0.03310113 FALSE TRUE
ENST00000532857 ENSG00000101493 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF516 protein_coding protein_coding 3.079065 2.426036 2.991298 0.1482172 0.1343181 0.301051 0.2277802 0.1676412 0.1449443 0.08382507 0.07438778 -0.1972170 0.06935833 0.06513333 0.0466000 -0.01853333 0.92544319 0.03310113   FALSE
ENST00000543743 ENSG00000101493 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF516 protein_coding processed_transcript 3.079065 2.426036 2.991298 0.1482172 0.1343181 0.301051 0.3893163 0.2703096 0.4823045 0.14243646 0.14372790 0.8125298 0.12781250 0.11790000 0.1592667 0.04136667 0.79668383 0.03310113   FALSE
ENST00000617840 ENSG00000101493 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF516 protein_coding protein_coding 3.079065 2.426036 2.991298 0.1482172 0.1343181 0.301051 0.4192900 0.3425016 0.6642322 0.11668497 0.13461821 0.9356157 0.12675833 0.13670000 0.2212333 0.08453333 0.50295228 0.03310113 FALSE TRUE
MSTRG.15922.5 ENSG00000101493 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF516 protein_coding   3.079065 2.426036 2.991298 0.1482172 0.1343181 0.301051 0.3217854 0.1182267 0.3336266 0.06356543 0.01693934 1.4221455 0.09992917 0.05190000 0.1122000 0.06030000 0.40700652 0.03310113 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000101493 E001 1.2929087 0.0612875193 6.127355e-03 1.894302e-02 18 76357682 76358196 515 - 0.000 0.537 11.964
ENSG00000101493 E002 29.7311163 0.0219546475 3.002286e-05 1.786575e-04 18 76358197 76358608 412 - 1.196 1.628 1.497
ENSG00000101493 E003 67.1506029 0.0127021313 6.931354e-08 7.259643e-07 18 76358609 76359295 687 - 1.574 1.961 1.308
ENSG00000101493 E004 136.9400021 0.0067947074 6.793562e-01 7.835690e-01 18 76359296 76361767 2472 - 2.115 2.151 0.120
ENSG00000101493 E005 37.1825942 0.0113113872 1.445332e-04 7.232843e-04 18 76361768 76362270 503 - 1.701 1.445 -0.875
ENSG00000101493 E006 33.1836779 0.0009043159 2.251874e-01 3.566443e-01 18 76362271 76362557 287 - 1.558 1.509 -0.168
ENSG00000101493 E007 11.4314360 0.0016492621 6.154164e-01 7.336933e-01 18 76370528 76370595 68 - 1.112 1.085 -0.099
ENSG00000101493 E008 19.0381231 0.0010846841 9.768630e-01 9.895611e-01 18 76371467 76371571 105 - 1.289 1.312 0.083
ENSG00000101493 E009 85.8158833 0.0014898490 4.707535e-02 1.039585e-01 18 76378855 76380303 1449 - 1.963 1.909 -0.183
ENSG00000101493 E010 54.8470776 0.0093478732 5.567661e-04 2.372844e-03 18 76441245 76442828 1584 - 1.840 1.644 -0.663
ENSG00000101493 E011 18.1975868 0.0093928914 1.457701e-02 3.953912e-02 18 76442829 76443211 383 - 1.378 1.176 -0.707
ENSG00000101493 E012 0.6224193 0.0172671820 8.833863e-01 9.293931e-01 18 76463028 76463141 114 - 0.226 0.209 -0.140
ENSG00000101493 E013 1.2931122 0.0103998145 8.347593e-01 8.965561e-01 18 76490681 76490779 99 - 0.374 0.350 -0.139
ENSG00000101493 E014 1.1008118 0.0120771510 5.719087e-01 6.981127e-01 18 76491447 76491503 57 - 0.374 0.286 -0.554
ENSG00000101493 E015 5.4771753 0.3065839630 6.927732e-01 7.939254e-01 18 76491969 76492445 477 - 0.811 0.795 -0.061
ENSG00000101493 E016 1.4006058 0.0114954467 6.144917e-01 7.329525e-01 18 76495144 76495242 99 - 0.306 0.407 0.600