ENSG00000101407

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373447 ENSG00000101407 HEK293_OSMI2_2hA HEK293_TMG_2hB TTI1 protein_coding protein_coding 20.40021 20.40039 20.17461 1.057948 0.2837326 -0.01604825 15.2028696 13.536803 16.878178 0.9460307 0.3457025 0.3180613 0.74537500 0.6645667 0.83730000 0.17273333 2.687744e-02 8.553435e-15 FALSE TRUE
MSTRG.20688.15 ENSG00000101407 HEK293_OSMI2_2hA HEK293_TMG_2hB TTI1 protein_coding   20.40021 20.40039 20.17461 1.057948 0.2837326 -0.01604825 0.6839124 0.000000 1.253304 0.0000000 0.6320367 6.9810578 0.03265000 0.0000000 0.06146667 0.06146667 1.830175e-01 8.553435e-15 FALSE FALSE
MSTRG.20688.8 ENSG00000101407 HEK293_OSMI2_2hA HEK293_TMG_2hB TTI1 protein_coding   20.40021 20.40039 20.17461 1.057948 0.2837326 -0.01604825 1.6862478 4.006015 0.000000 1.0328324 0.0000000 -8.6496210 0.08390833 0.1943667 0.00000000 -0.19436667 8.553435e-15 8.553435e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000101407 E001 0.9965258 0.0142674504 3.321423e-01 4.757730e-01 20 37983007 37983020 14 - 0.384 0.203 -1.255
ENSG00000101407 E002 1.0267148 0.0443353256 8.887182e-01 9.328217e-01 20 37983021 37983021 1 - 0.315 0.278 -0.250
ENSG00000101407 E003 1.9822521 0.0073856817 3.570207e-01 5.014383e-01 20 37983022 37983030 9 - 0.384 0.529 0.743
ENSG00000101407 E004 48.1417257 0.0037198394 4.707308e-05 2.669537e-04 20 37983031 37983092 62 - 1.546 1.772 0.770
ENSG00000101407 E005 125.2363961 0.0036314951 8.973670e-06 6.031915e-05 20 37983093 37983226 134 - 1.988 2.163 0.584
ENSG00000101407 E006 69.6589832 0.0045802567 6.489975e-06 4.502974e-05 20 37983227 37983228 2 - 1.700 1.929 0.775
ENSG00000101407 E007 96.9528262 0.0070501859 4.003220e-06 2.912099e-05 20 37983229 37983274 46 - 1.834 2.070 0.795
ENSG00000101407 E008 60.9987882 0.0072900317 2.562751e-04 1.201390e-03 20 37983275 37983275 1 - 1.654 1.864 0.711
ENSG00000101407 E009 272.4522074 0.0052582561 9.426756e-08 9.616966e-07 20 37983276 37983639 364 - 2.309 2.500 0.637
ENSG00000101407 E010 148.1165053 0.0048959226 1.798040e-03 6.593114e-03 20 37996375 37996462 88 - 2.095 2.215 0.402
ENSG00000101407 E011 202.5231943 0.0003284056 1.635464e-02 4.350621e-02 20 37996749 37996953 205 - 2.280 2.322 0.141
ENSG00000101407 E012 154.1505004 0.0003044675 9.201207e-02 1.782499e-01 20 37999188 37999328 141 - 2.171 2.201 0.101
ENSG00000101407 E013 2.2486364 0.0126043541 4.289262e-01 5.716612e-01 20 38000405 38000515 111 - 0.444 0.565 0.588
ENSG00000101407 E014 0.2924217 0.0290785164 1.699447e-01   20 38002006 38002036 31 - 0.233 0.000 -11.673
ENSG00000101407 E015 153.2102662 0.0002439188 2.155136e-01 3.450354e-01 20 38002628 38002774 147 - 2.173 2.190 0.056
ENSG00000101407 E016 71.1526706 0.0004055112 9.080759e-01 9.456462e-01 20 38002775 38002776 2 - 1.862 1.849 -0.045
ENSG00000101407 E017 4.5026717 0.0036708776 5.443999e-01 6.748774e-01 20 38005840 38006196 357 - 0.691 0.761 0.284
ENSG00000101407 E018 203.3390291 0.0002040039 4.000605e-01 5.437749e-01 20 38006197 38006397 201 - 2.305 2.308 0.008
ENSG00000101407 E019 230.3388583 0.0002425502 1.262931e-01 2.289906e-01 20 38011515 38011807 293 - 2.390 2.336 -0.182
ENSG00000101407 E020 273.6762698 0.0013713073 1.767516e-03 6.496151e-03 20 38011808 38012222 415 - 2.491 2.387 -0.345
ENSG00000101407 E021 130.6665447 0.0026909408 3.544866e-03 1.185382e-02 20 38012223 38012350 128 - 2.189 2.055 -0.449
ENSG00000101407 E022 166.2477407 0.0002428919 7.251827e-05 3.923007e-04 20 38012351 38012538 188 - 2.290 2.164 -0.422
ENSG00000101407 E023 552.5168285 0.0065583810 5.714944e-07 5.000596e-06 20 38012539 38013699 1161 - 2.845 2.641 -0.680
ENSG00000101407 E024 109.1825919 0.0220890347 2.669771e-02 6.536178e-02 20 38013700 38013857 158 - 2.141 1.943 -0.663
ENSG00000101407 E025 1.0351233 0.0119307037 2.261158e-03 8.033938e-03 20 38013858 38013903 46 - 0.543 0.000 -13.480
ENSG00000101407 E026 4.7812777 0.0043338688 4.705869e-01 6.098149e-01 20 38019005 38019144 140 - 0.825 0.713 -0.450
ENSG00000101407 E027 49.2116727 0.0100543182 8.639281e-02 1.696294e-01 20 38033404 38033461 58 - 1.773 1.632 -0.476