ENSG00000101391

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Rows: 1-5 / 5
Columns:
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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC

ENST00000346416	ENSG00000101391	HEK293_OSMI2_2hA	HEK293_TMG_2hB	CDK5RAP1	protein_coding	protein_coding	49.40786	69.69215	34.47392	5.248059	0.8128439	-1.015279	20.387618	28.524181	16.1028939	1.53767590	0.9502660	-0.8244755	0.41922500	0.41486667	0.46693333	0.05206667	6.805738e-01	4.848276e-20	FALSE
ENST00000473791	ENSG00000101391	HEK293_OSMI2_2hA	HEK293_TMG_2hB	CDK5RAP1	protein_coding	retained_intron	49.40786	69.69215	34.47392	5.248059	0.8128439	-1.015279	2.916245	1.497973	3.3782353	0.09930589	0.2954571	1.1679234	0.06653333	0.02150000	0.09776667	0.07626667	4.848276e-20	4.848276e-20	FALSE
ENST00000482967	ENSG00000101391	HEK293_OSMI2_2hA	HEK293_TMG_2hB	CDK5RAP1	protein_coding	processed_transcript	49.40786	69.69215	34.47392	5.248059	0.8128439	-1.015279	2.766257	6.620647	0.9948314	2.12665205	0.7526591	-2.7221962	0.04901667	0.09136667	0.02790000	-0.06346667	3.687425e-01	4.848276e-20	FALSE
MSTRG.20564.13	ENSG00000101391	HEK293_OSMI2_2hA	HEK293_TMG_2hB	CDK5RAP1	protein_coding		49.40786	69.69215	34.47392	5.248059	0.8128439	-1.015279	9.460479	16.482510	3.8784591	3.80137105	1.0679392	-2.0845405	0.17620417	0.23443333	0.11210000	-0.12233333	1.511904e-01	4.848276e-20	FALSE
MSTRG.20564.14	ENSG00000101391	HEK293_OSMI2_2hA	HEK293_TMG_2hB	CDK5RAP1	protein_coding		49.40786	69.69215	34.47392	5.248059	0.8128439	-1.015279	5.616539	7.449640	2.3861009	0.96245063	1.4599081	-1.6384173	0.11507083	0.10850000	0.07043333	-0.03806667	7.238142e-01	4.848276e-20	FALSE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

Rows: 1-10 / 31
Columns:
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groupID
featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
start
end
width
strand
HEK293_TMG_2hB
HEK293_OSMI2_2hA
log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_2hB	HEK293_OSMI2_2hA	log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB

ENSG00000101391	E001	2.246457	0.0068496486	5.569100e-02	1.191688e-01	20	33358839	33358840	2	-	0.177	0.547	2.329
ENSG00000101391	E002	2.549488	0.0058330055	4.144186e-01	5.578357e-01	20	33358841	33358842	2	-	0.399	0.547	0.745
ENSG00000101391	E003	2.885815	0.0114935184	2.799868e-01	4.197851e-01	20	33358843	33358844	2	-	0.399	0.596	0.965
ENSG00000101391	E004	3.579221	0.0043176468	1.083508e-01	2.031043e-01	20	33358845	33358846	2	-	0.399	0.680	1.329
ENSG00000101391	E005	21.050530	0.0014051355	2.242023e-06	1.725271e-05	20	33358847	33358886	40	-	0.905	1.383	1.717
ENSG00000101391	E006	425.874175	0.0016786680	1.046177e-04	5.433573e-04	20	33358887	33359087	201	-	2.493	2.601	0.359
ENSG00000101391	E007	322.811069	0.0019031632	1.524973e-04	7.580929e-04	20	33359088	33359123	36	-	2.365	2.484	0.395
ENSG00000101391	E008	33.432568	0.0093173864	9.563472e-04	3.809443e-03	20	33359124	33360350	1227	-	1.656	1.414	-0.827
ENSG00000101391	E009	511.799255	0.0007692491	2.994184e-04	1.377247e-03	20	33360351	33360491	141	-	2.595	2.675	0.266
ENSG00000101391	E010	347.233799	0.0027211181	5.848091e-04	2.477478e-03	20	33366859	33366907	49	-	2.399	2.514	0.383
ENSG00000101391	E011	472.102623	0.0007606673	3.408567e-04	1.543805e-03	20	33366908	33367005	98	-	2.559	2.640	0.271
ENSG00000101391	E012	228.392264	0.0001822785	2.996665e-02	7.189560e-02	20	33367006	33367008	3	-	2.261	2.322	0.204
ENSG00000101391	E013	436.381867	0.0002709585	1.232023e-04	6.285427e-04	20	33370499	33370629	131	-	2.525	2.605	0.266
ENSG00000101391	E014	257.153564	0.0012058191	1.146997e-02	3.228226e-02	20	33372642	33372697	56	-	2.299	2.377	0.261
ENSG00000101391	E015	62.789873	0.0004741078	3.715108e-33	7.890315e-31	20	33372698	33373359	662	-	2.074	1.545	-1.786
ENSG00000101391	E016	36.777155	0.0007104273	5.080431e-32	9.821148e-30	20	33373601	33374114	514	-	1.905	1.231	-2.311
ENSG00000101391	E017	337.552066	0.0006429845	8.622514e-01	9.151621e-01	20	33374115	33374212	98	-	2.471	2.478	0.024
ENSG00000101391	E018	241.207980	0.0002482387	4.796882e-01	6.180209e-01	20	33379461	33379512	52	-	2.343	2.328	-0.049
ENSG00000101391	E019	400.601813	0.0001854074	4.340068e-02	9.729638e-02	20	33379513	33379691	179	-	2.575	2.538	-0.124
ENSG00000101391	E020	6.565530	0.0218391015	4.892712e-04	2.119280e-03	20	33381984	33382094	111	-	1.116	0.642	-1.832
ENSG00000101391	E021	4.752130	0.0034035118	1.748344e-01	2.944793e-01	20	33383480	33383521	42	-	0.847	0.661	-0.753
ENSG00000101391	E022	290.821793	0.0033449069	1.308474e-02	3.610611e-02	20	33385650	33385770	121	-	2.471	2.383	-0.295
ENSG00000101391	E023	317.110953	0.0020762918	1.257777e-01	2.282529e-01	20	33387323	33387533	211	-	2.479	2.432	-0.157
ENSG00000101391	E024	244.346458	0.0008073732	2.774409e-04	1.287739e-03	20	33392142	33392242	101	-	2.404	2.308	-0.324
ENSG00000101391	E025	148.709586	0.0002509802	1.530569e-04	7.606552e-04	20	33394032	33394066	35	-	2.204	2.089	-0.384
ENSG00000101391	E026	199.799463	0.0022613139	2.341915e-02	5.861966e-02	20	33395013	33395116	104	-	2.303	2.224	-0.265
ENSG00000101391	E027	175.653946	0.0056339082	2.133875e-02	5.430120e-02	20	33396761	33396844	84	-	2.266	2.158	-0.359
ENSG00000101391	E028	110.417681	0.0097116409	2.967166e-01	4.379798e-01	20	33396845	33396852	8	-	2.036	1.970	-0.221
ENSG00000101391	E029	157.276194	0.0043493757	8.447742e-02	1.665643e-01	20	33396853	33396936	84	-	2.197	2.119	-0.260
ENSG00000101391	E030	147.958674	0.0026979389	4.602055e-02	1.020729e-01	20	33396937	33397084	148	-	2.173	2.092	-0.270
ENSG00000101391	E031	102.173337	0.0078160446	8.325543e-01	8.950759e-01	20	33401428	33401561	134	-	1.966	1.951	-0.049

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000101391

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3