ENSG00000101347

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262878 ENSG00000101347 HEK293_OSMI2_2hA HEK293_TMG_2hB SAMHD1 protein_coding protein_coding 16.98377 9.589884 23.38381 0.2593194 1.003521 1.285038 1.942908 0.3933349 3.969347 0.3933349 1.3736688 3.3024815 0.09298333 0.04163333 0.1733667 0.1317333 1.827853e-01 8.704089e-10 FALSE TRUE
ENST00000646673 ENSG00000101347 HEK293_OSMI2_2hA HEK293_TMG_2hB SAMHD1 protein_coding protein_coding 16.98377 9.589884 23.38381 0.2593194 1.003521 1.285038 11.732550 8.6297345 14.314059 0.6746885 1.8390154 0.7293815 0.74732083 0.89880000 0.6111333 -0.2876667 2.795491e-02 8.704089e-10 FALSE TRUE
MSTRG.20675.13 ENSG00000101347 HEK293_OSMI2_2hA HEK293_TMG_2hB SAMHD1 protein_coding   16.98377 9.589884 23.38381 0.2593194 1.003521 1.285038 1.612414 0.0000000 2.382739 0.0000000 0.6326043 7.9025192 0.06695000 0.00000000 0.1003667 0.1003667 8.704089e-10 8.704089e-10 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000101347 E001 7.3901882 0.0539109638 2.331416e-02 5.840392e-02 20 36890229 36890250 22 - 0.747 1.107 1.362
ENSG00000101347 E002 12.0727533 0.0385093905 4.489238e-03 1.451219e-02 20 36890251 36890261 11 - 0.910 1.320 1.479
ENSG00000101347 E003 14.8436783 0.0399290147 1.555980e-02 4.175532e-02 20 36890262 36890268 7 - 1.028 1.379 1.248
ENSG00000101347 E004 25.5253831 0.0414765259 1.754477e-02 4.613896e-02 20 36890269 36890393 125 - 1.272 1.585 1.081
ENSG00000101347 E005 16.0145758 0.0524235527 5.494280e-02 1.178927e-01 20 36890394 36890438 45 - 1.089 1.389 1.062
ENSG00000101347 E006 11.3959634 0.0474368726 1.102859e-01 2.059675e-01 20 36890439 36890444 6 - 0.978 1.233 0.920
ENSG00000101347 E007 32.8720996 0.0386308405 1.684904e-03 6.234863e-03 20 36890445 36890518 74 - 1.344 1.713 1.263
ENSG00000101347 E008 25.4834912 0.0466592371 8.275005e-04 3.357696e-03 20 36890519 36890523 5 - 1.207 1.625 1.443
ENSG00000101347 E009 49.9279766 0.0212475266 1.441036e-05 9.226713e-05 20 36890524 36890573 50 - 1.508 1.895 1.311
ENSG00000101347 E010 47.5062869 0.0086748774 1.767702e-07 1.712008e-06 20 36890574 36890578 5 - 1.499 1.871 1.261
ENSG00000101347 E011 196.9072780 0.0006240780 5.880899e-30 9.894483e-28 20 36890579 36890903 325 - 2.134 2.458 1.083
ENSG00000101347 E012 372.1375935 0.0012339776 3.270889e-11 6.259825e-10 20 36890904 36891552 649 - 2.487 2.658 0.570
ENSG00000101347 E013 129.0108197 0.0027574874 2.022276e-04 9.734400e-04 20 36891553 36891690 138 - 2.033 2.194 0.539
ENSG00000101347 E014 83.0772408 0.0164069908 1.133888e-01 2.104635e-01 20 36891691 36891794 104 - 1.861 1.986 0.420
ENSG00000101347 E015 34.1271223 0.0102351349 4.392811e-01 5.810310e-01 20 36891795 36891801 7 - 1.550 1.503 -0.163
ENSG00000101347 E016 32.9844933 0.0094749715 3.769774e-01 5.213084e-01 20 36891802 36891807 6 - 1.539 1.483 -0.191
ENSG00000101347 E017 347.9592919 0.0001645060 2.036700e-02 5.225796e-02 20 36891808 36892578 771 - 2.508 2.569 0.202
ENSG00000101347 E018 48.8051592 0.0058353043 6.884219e-01 7.905599e-01 20 36892579 36892618 40 - 1.687 1.674 -0.045
ENSG00000101347 E019 60.9253044 0.0003914731 5.926477e-02 1.253815e-01 20 36892619 36892715 97 - 1.737 1.840 0.345
ENSG00000101347 E020 39.9803118 0.0005667095 1.942950e-05 1.209099e-04 20 36892716 36892739 24 - 1.490 1.743 0.860
ENSG00000101347 E021 32.9366979 0.0054759278 1.902813e-05 1.186187e-04 20 36892740 36892746 7 - 1.376 1.691 1.079
ENSG00000101347 E022 34.9970822 0.0123924437 1.384864e-05 8.904369e-05 20 36892747 36892762 16 - 1.372 1.738 1.254
ENSG00000101347 E023 35.9162925 0.0050161498 2.870569e-06 2.156991e-05 20 36892763 36892770 8 - 1.405 1.734 1.124
ENSG00000101347 E024 58.7164816 0.0004129797 4.223589e-06 3.054926e-05 20 36892771 36892807 37 - 1.666 1.894 0.770
ENSG00000101347 E025 120.1489313 0.0003348521 2.444498e-02 6.074118e-02 20 36892808 36892931 124 - 2.033 2.124 0.304
ENSG00000101347 E026 144.8360586 0.0023859622 3.350011e-01 4.787459e-01 20 36892932 36893066 135 - 2.130 2.182 0.175
ENSG00000101347 E027 8.7866651 0.0282445557 7.881339e-01 8.643203e-01 20 36893067 36893929 863 - 0.989 0.966 -0.087
ENSG00000101347 E028 1.5553580 0.0196725768 7.874932e-01 8.639077e-01 20 36897571 36897668 98 - 0.417 0.377 -0.224
ENSG00000101347 E029 1.3651314 0.0367083355 1.163547e-01 2.147504e-01 20 36897669 36897821 153 - 0.228 0.519 1.739
ENSG00000101347 E030 131.8061179 0.0002283777 6.802845e-01 7.842070e-01 20 36897822 36897959 138 - 2.101 2.130 0.097
ENSG00000101347 E031 103.7990270 0.0018045537 1.073680e-01 2.016610e-01 20 36898440 36898544 105 - 2.028 1.976 -0.172
ENSG00000101347 E032 0.4751703 0.0207215445 2.567849e-01 3.937827e-01 20 36903953 36904021 69 - 0.090 0.283 1.999
ENSG00000101347 E033 1.8154127 0.0113202757 9.475444e-01 9.710089e-01 20 36904022 36904156 135 - 0.453 0.453 -0.003
ENSG00000101347 E034 111.3063175 0.0003201614 1.200741e-03 4.642952e-03 20 36904157 36904249 93 - 2.073 1.973 -0.336
ENSG00000101347 E035 0.9684132 0.0167851396 3.475630e-01 4.917845e-01 20 36904250 36905363 1114 - 0.333 0.165 -1.321
ENSG00000101347 E036 132.4144290 0.0004278472 1.743142e-07 1.690728e-06 20 36905364 36905503 140 - 2.166 2.004 -0.542
ENSG00000101347 E037 121.8806754 0.0015107693 2.405114e-04 1.135414e-03 20 36911218 36911333 116 - 2.119 1.992 -0.426
ENSG00000101347 E038 1.9908510 0.0072613633 2.542657e-02 6.275960e-02 20 36911334 36912247 914 - 0.575 0.164 -2.584
ENSG00000101347 E039 0.4439371 0.0215760650 2.450064e-01 3.800391e-01 20 36912248 36912347 100 - 0.228 0.000 -12.579
ENSG00000101347 E040 0.2966881 0.0290785164 4.524774e-01   20 36912348 36912460 113 - 0.164 0.000 -11.912
ENSG00000101347 E041 112.8477716 0.0002962628 6.158681e-05 3.392683e-04 20 36912461 36912552 92 - 2.086 1.958 -0.429
ENSG00000101347 E042 0.0000000       20 36916531 36916721 191 -      
ENSG00000101347 E043 54.6760371 0.0004420879 3.367044e-04 1.527226e-03 20 36916722 36916722 1 - 1.787 1.618 -0.574
ENSG00000101347 E044 105.0388793 0.0010052948 4.794234e-06 3.428664e-05 20 36916723 36916830 108 - 2.066 1.899 -0.561
ENSG00000101347 E045 93.8673831 0.0003298452 1.445404e-06 1.160139e-05 20 36916949 36917049 101 - 2.021 1.845 -0.591
ENSG00000101347 E046 0.7708142 0.0152430775 4.957478e-01 6.324982e-01 20 36917050 36917096 47 - 0.283 0.164 -1.000
ENSG00000101347 E047 0.0000000       20 36917152 36917215 64 -      
ENSG00000101347 E048 116.9981583 0.0003007688 2.502221e-06 1.906141e-05 20 36919364 36919519 156 - 2.109 1.958 -0.506
ENSG00000101347 E049 0.2966881 0.0290785164 4.524774e-01   20 36926952 36927181 230 - 0.164 0.000 -11.912
ENSG00000101347 E050 105.8761143 0.0083429155 1.737751e-04 8.517329e-04 20 36927182 36927252 71 - 2.079 1.874 -0.688
ENSG00000101347 E051 0.3666179 0.0306678076 6.276376e-01 7.434150e-01 20 36929016 36929053 38 - 0.090 0.165 1.003
ENSG00000101347 E052 82.3183219 0.0003708486 5.550081e-05 3.091670e-04 20 36930760 36930798 39 - 1.958 1.803 -0.520
ENSG00000101347 E053 110.2639599 0.0003093224 1.341815e-10 2.319792e-09 20 36930799 36930875 77 - 2.104 1.881 -0.749
ENSG00000101347 E054 0.1451727 0.0429475159 1.000000e+00   20 36930978 36931049 72 - 0.090 0.000 -10.769
ENSG00000101347 E055 0.1472490 0.0439927621 1.000000e+00   20 36934658 36935028 371 - 0.090 0.000 -10.759
ENSG00000101347 E056 99.8597031 0.0043384646 2.193747e-08 2.539093e-07 20 36935029 36935080 52 - 2.073 1.801 -0.916
ENSG00000101347 E057 133.2076625 0.0004360446 1.679016e-13 4.628705e-12 20 36935081 36935189 109 - 2.190 1.949 -0.806
ENSG00000101347 E058 0.2934659 0.0288104900 6.320581e-01   20 36935190 36935203 14 - 0.090 0.164 0.998
ENSG00000101347 E059 0.1515154 0.0431835895 1.000000e+00   20 36935341 36935403 63 - 0.090 0.000 -10.768
ENSG00000101347 E060 0.0000000       20 36940165 36941038 874 -      
ENSG00000101347 E061 100.7053592 0.0027134666 1.135618e-11 2.342800e-10 20 36941039 36941111 73 - 2.086 1.778 -1.035
ENSG00000101347 E062 0.0000000       20 36946409 36946737 329 -      
ENSG00000101347 E063 72.1861129 0.0050171251 3.529845e-08 3.918196e-07 20 36946738 36946804 67 - 1.944 1.633 -1.053
ENSG00000101347 E064 0.0000000       20 36946911 36947059 149 -      
ENSG00000101347 E065 113.8328942 0.0002835029 3.860198e-19 2.235717e-17 20 36951436 36951893 458 - 2.142 1.819 -1.084