ENSG00000101337

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000398022 ENSG00000101337 HEK293_OSMI2_2hA HEK293_TMG_2hB TM9SF4 protein_coding protein_coding 48.91804 46.92729 46.34106 2.795136 0.5378288 -0.01813227 41.35722 41.3993 37.5255 1.883873 0.563597 -0.1416992 0.8446375 0.8838 0.8097333 -0.07406667 0.01326209 1.67632e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000101337 E001 0.4438354 0.1593435619 6.833369e-01 7.865651e-01 20 32109440 32109518 79 + 0.127 0.208 0.862
ENSG00000101337 E002 0.9650892 0.0383155385 5.190575e-01 6.531904e-01 20 32109519 32109521 3 + 0.225 0.352 0.880
ENSG00000101337 E003 3.1740982 0.0272772638 4.128592e-01 5.564366e-01 20 32109522 32109546 25 + 0.528 0.677 0.662
ENSG00000101337 E004 4.6122693 0.0099862357 6.788207e-01 7.831946e-01 20 32109547 32109587 41 + 0.704 0.778 0.300
ENSG00000101337 E005 16.8690583 0.0011014963 5.448050e-01 6.752304e-01 20 32109588 32109713 126 + 1.262 1.229 -0.113
ENSG00000101337 E006 10.5367551 0.0056436741 1.279463e-01 2.313040e-01 20 32109714 32109716 3 + 1.120 0.977 -0.523
ENSG00000101337 E007 16.9142762 0.0062610624 7.018412e-02 1.436678e-01 20 32109717 32109727 11 + 1.315 1.171 -0.505
ENSG00000101337 E008 51.3196979 0.0005824983 2.253245e-01 3.567988e-01 20 32109728 32109735 8 + 1.734 1.692 -0.141
ENSG00000101337 E009 135.1658715 0.0031644365 4.726090e-07 4.200336e-06 20 32109736 32109755 20 + 2.221 2.037 -0.619
ENSG00000101337 E010 0.7406253 0.0155690104 1.199165e-02 3.351118e-02 20 32109756 32109766 11 + 0.430 0.000 -11.822
ENSG00000101337 E011 6.6085207 0.0034977712 1.731782e-02 4.564286e-02 20 32109767 32110039 273 + 1.006 0.731 -1.060
ENSG00000101337 E012 285.5345184 0.0002291140 4.797344e-14 1.428099e-12 20 32133013 32133126 114 + 2.527 2.382 -0.481
ENSG00000101337 E013 318.8769943 0.0001993584 2.172950e-10 3.614847e-09 20 32136074 32136173 100 + 2.558 2.447 -0.369
ENSG00000101337 E014 5.2599638 0.0101581044 8.553288e-04 3.456474e-03 20 32136877 32136997 121 + 0.991 0.544 -1.814
ENSG00000101337 E015 231.8997157 0.0002410745 1.193136e-07 1.195135e-06 20 32141497 32141540 44 + 2.417 2.309 -0.359
ENSG00000101337 E016 376.9295043 0.0012125962 1.130238e-07 1.137029e-06 20 32141541 32141665 125 + 2.629 2.521 -0.362
ENSG00000101337 E017 389.7965893 0.0017684869 2.392888e-05 1.458247e-04 20 32141766 32141895 130 + 2.635 2.544 -0.303
ENSG00000101337 E018 324.8509389 0.0001547317 2.349473e-07 2.222059e-06 20 32142982 32143077 96 + 2.551 2.467 -0.282
ENSG00000101337 E019 177.0498988 0.0038299307 5.073406e-03 1.613114e-02 20 32143078 32143105 28 + 2.295 2.202 -0.309
ENSG00000101337 E020 320.2082838 0.0005049114 3.527519e-08 3.915844e-07 20 32145091 32145209 119 + 2.554 2.452 -0.341
ENSG00000101337 E021 319.7026840 0.0012809603 9.108137e-04 3.651949e-03 20 32145312 32145423 112 + 2.535 2.470 -0.218
ENSG00000101337 E022 249.3861364 0.0001764206 2.366763e-02 5.912757e-02 20 32146785 32146855 71 + 2.410 2.378 -0.109
ENSG00000101337 E023 368.9353409 0.0001299444 5.723062e-03 1.788016e-02 20 32149634 32149766 133 + 2.580 2.547 -0.109
ENSG00000101337 E024 314.5993647 0.0009754870 5.898453e-03 1.834415e-02 20 32150622 32150703 82 + 2.519 2.471 -0.158
ENSG00000101337 E025 302.7962906 0.0001828807 2.028298e-01 3.297703e-01 20 32150800 32150875 76 + 2.479 2.471 -0.026
ENSG00000101337 E026 257.6109121 0.0001998161 2.822744e-01 4.222449e-01 20 32155103 32155186 84 + 2.408 2.403 -0.018
ENSG00000101337 E027 400.1320490 0.0001468430 3.412167e-01 4.851290e-01 20 32157794 32157969 176 + 2.596 2.598 0.006
ENSG00000101337 E028 289.5556885 0.0017434743 5.236561e-01 6.572876e-01 20 32158451 32158514 64 + 2.457 2.460 0.009
ENSG00000101337 E029 15.7538191 0.0021223599 3.442009e-01 4.882653e-01 20 32159143 32159991 849 + 1.152 1.253 0.357
ENSG00000101337 E030 450.4959885 0.0001313360 1.853404e-01 3.079151e-01 20 32159992 32160111 120 + 2.624 2.666 0.139
ENSG00000101337 E031 0.8512514 0.0136968632 2.146580e-01 3.440386e-01 20 32161093 32161275 183 + 0.127 0.352 1.885
ENSG00000101337 E032 367.3364962 0.0001858011 2.245264e-08 2.592701e-07 20 32161276 32161365 90 + 2.482 2.610 0.426
ENSG00000101337 E033 1797.9338415 0.0003117105 3.879469e-28 5.542638e-26 20 32165295 32166608 1314 + 3.168 3.303 0.449
ENSG00000101337 E034 734.2307992 0.0042023102 2.311680e-07 2.189923e-06 20 32166609 32166972 364 + 2.744 2.935 0.635
ENSG00000101337 E035 403.3176050 0.0040152116 1.041910e-09 1.540038e-08 20 32166973 32167258 286 + 2.452 2.690 0.792
ENSG00000101337 E036 2.5744679 0.0057500435 2.909761e-01 4.317872e-01 20 32170358 32170507 150 + 0.430 0.616 0.887