ENSG00000101246

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000609537 ENSG00000101246 HEK293_OSMI2_2hA HEK293_TMG_2hB ARFRP1 protein_coding retained_intron 38.48016 55.73591 22.9161 2.675214 0.5931085 -1.281875 2.523813 1.6475874 2.140039 0.2278492 0.1862160 0.3752779 0.07085417 0.02960000 0.09323333 0.063633333 1.695089e-06 1.695089e-06 FALSE  
ENST00000610414 ENSG00000101246 HEK293_OSMI2_2hA HEK293_TMG_2hB ARFRP1 protein_coding processed_transcript 38.48016 55.73591 22.9161 2.675214 0.5931085 -1.281875 2.201540 2.6763215 1.120970 0.3500505 0.3227903 -1.2480712 0.05533750 0.04773333 0.04876667 0.001033333 9.926378e-01 1.695089e-06 FALSE  
ENST00000612157 ENSG00000101246 HEK293_OSMI2_2hA HEK293_TMG_2hB ARFRP1 protein_coding protein_coding 38.48016 55.73591 22.9161 2.675214 0.5931085 -1.281875 4.387353 8.7161390 2.092020 0.7621801 0.3103846 -2.0535674 0.10401667 0.15646667 0.09206667 -0.064400000 8.824382e-02 1.695089e-06 FALSE  
ENST00000612772 ENSG00000101246 HEK293_OSMI2_2hA HEK293_TMG_2hB ARFRP1 protein_coding processed_transcript 38.48016 55.73591 22.9161 2.675214 0.5931085 -1.281875 1.926811 1.8503407 1.451994 0.3238627 0.2524058 -0.3476291 0.05342917 0.03336667 0.06383333 0.030466667 1.915341e-01 1.695089e-06 FALSE  
ENST00000618838 ENSG00000101246 HEK293_OSMI2_2hA HEK293_TMG_2hB ARFRP1 protein_coding protein_coding 38.48016 55.73591 22.9161 2.675214 0.5931085 -1.281875 8.694307 17.6906301 1.332536 1.2097271 0.6973164 -3.7207677 0.20599583 0.31706667 0.05763333 -0.259433333 2.125409e-01 1.695089e-06 FALSE  
MSTRG.21010.11 ENSG00000101246 HEK293_OSMI2_2hA HEK293_TMG_2hB ARFRP1 protein_coding   38.48016 55.73591 22.9161 2.675214 0.5931085 -1.281875 6.642569 12.0519927 6.175051 0.8135761 1.4873186 -0.9636108 0.17116250 0.21853333 0.27196667 0.053433333 8.270958e-01 1.695089e-06 FALSE  
MSTRG.21010.19 ENSG00000101246 HEK293_OSMI2_2hA HEK293_TMG_2hB ARFRP1 protein_coding   38.48016 55.73591 22.9161 2.675214 0.5931085 -1.281875 3.531335 0.7332016 2.196927 0.7332016 0.3623759 1.5702133 0.10507083 0.01200000 0.09523333 0.083233333 6.107923e-02 1.695089e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000101246 E001 0.000000       20 63698642 63698642 1 -      
ENSG00000101246 E002 0.000000       20 63698643 63698646 4 -      
ENSG00000101246 E003 10.695034 0.0020580976 2.599772e-02 6.394276e-02 20 63698647 63698887 241 - 1.166 0.927 -0.875
ENSG00000101246 E004 7.460482 0.0109522884 6.601431e-02 1.367262e-01 20 63698888 63698918 31 - 1.028 0.793 -0.894
ENSG00000101246 E005 9.370929 0.0018527625 1.792152e-02 4.696738e-02 20 63698919 63699008 90 - 1.131 0.865 -0.984
ENSG00000101246 E006 15.693982 0.0124740957 1.071779e-02 3.049556e-02 20 63699009 63699455 447 - 1.332 1.066 -0.944
ENSG00000101246 E007 18.752884 0.0020066397 4.066084e-01 5.502393e-01 20 63699456 63699477 22 - 1.149 1.226 0.275
ENSG00000101246 E008 21.951931 0.0009575301 1.433710e-01 2.526036e-01 20 63699478 63699496 19 - 1.166 1.297 0.462
ENSG00000101246 E009 34.940908 0.0007290968 1.465334e-03 5.524220e-03 20 63699497 63699511 15 - 1.270 1.514 0.843
ENSG00000101246 E010 146.248825 0.0040323208 4.125973e-06 2.990910e-05 20 63699512 63699610 99 - 1.897 2.123 0.759
ENSG00000101246 E011 202.694401 0.0011675807 5.642951e-06 3.969110e-05 20 63699611 63699700 90 - 2.095 2.253 0.528
ENSG00000101246 E012 565.240987 0.0001684715 3.162203e-07 2.911923e-06 20 63699701 63700053 353 - 2.592 2.683 0.302
ENSG00000101246 E013 260.479180 0.0004414357 9.020442e-06 6.059914e-05 20 63700054 63700166 113 - 2.229 2.353 0.414
ENSG00000101246 E014 93.149301 0.0035137917 2.113740e-02 5.388871e-02 20 63700167 63700169 3 - 1.791 1.912 0.407
ENSG00000101246 E015 227.983334 0.0013413793 1.055005e-03 4.149902e-03 20 63700170 63700301 132 - 2.184 2.292 0.359
ENSG00000101246 E016 385.029284 0.0006176131 1.098956e-01 2.053904e-01 20 63700302 63700525 224 - 2.468 2.505 0.121
ENSG00000101246 E017 160.105985 0.0034527483 7.493231e-01 8.363105e-01 20 63700526 63700530 5 - 2.131 2.116 -0.051
ENSG00000101246 E018 56.345267 0.0058643627 8.048659e-01 8.758444e-01 20 63700531 63700601 71 - 1.657 1.676 0.064
ENSG00000101246 E019 307.693219 0.0002930408 9.667723e-01 9.831689e-01 20 63700602 63700702 101 - 2.404 2.402 -0.008
ENSG00000101246 E020 20.004031 0.0361865056 1.903743e-01 3.142335e-01 20 63700703 63700777 75 - 1.355 1.193 -0.567
ENSG00000101246 E021 23.383058 0.0008318243 1.115074e-04 5.746509e-04 20 63701190 63701388 199 - 1.517 1.226 -1.010
ENSG00000101246 E022 14.420037 0.0018576605 9.252683e-05 4.868742e-04 20 63701697 63701829 133 - 1.354 0.989 -1.303
ENSG00000101246 E023 258.214668 0.0003306829 8.223965e-01 8.880307e-01 20 63701830 63701895 66 - 2.333 2.326 -0.025
ENSG00000101246 E024 146.519859 0.0002775173 7.792640e-01 8.580352e-01 20 63701896 63701898 3 - 2.093 2.082 -0.038
ENSG00000101246 E025 139.312043 0.0002882531 8.365600e-01 8.978030e-01 20 63701899 63701900 2 - 2.058 2.063 0.018
ENSG00000101246 E026 315.248881 0.0001563331 5.495891e-01 6.793022e-01 20 63702136 63702217 82 - 2.402 2.414 0.041
ENSG00000101246 E027 147.138802 0.0049306078 1.226337e-10 2.133191e-09 20 63702218 63705578 3361 - 2.294 2.001 -0.980
ENSG00000101246 E028 17.727838 0.0010662416 1.309086e-08 1.579533e-07 20 63705579 63705791 213 - 1.509 1.043 -1.639
ENSG00000101246 E029 14.550351 0.0012546310 1.671427e-07 1.626749e-06 20 63705792 63706053 262 - 1.425 0.955 -1.677
ENSG00000101246 E030 305.802586 0.0001614266 5.368318e-01 6.685324e-01 20 63706357 63706439 83 - 2.412 2.396 -0.054
ENSG00000101246 E031 281.032008 0.0001555373 1.785461e-02 4.682311e-02 20 63706651 63706738 88 - 2.408 2.349 -0.197
ENSG00000101246 E032 6.122662 0.0028857023 2.040089e-03 7.351470e-03 20 63706739 63706874 136 - 1.051 0.657 -1.533
ENSG00000101246 E033 193.909707 0.0007242579 1.821504e-04 8.871366e-04 20 63706999 63707092 94 - 2.290 2.173 -0.390
ENSG00000101246 E034 38.817321 0.0006015414 5.177969e-05 2.906004e-04 20 63707093 63707097 5 - 1.693 1.447 -0.841
ENSG00000101246 E035 11.448040 0.0299110176 3.045769e-08 3.423793e-07 20 63707098 63707658 561 - 1.434 0.743 -2.530
ENSG00000101246 E036 9.860960 0.0018118536 5.556987e-02 1.189540e-01 20 63707810 63707853 44 - 1.112 0.897 -0.794
ENSG00000101246 E037 85.894294 0.0003046198 1.308306e-06 1.059570e-05 20 63707867 63708025 159 - 2.002 1.799 -0.683