ENSG00000101199

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370283 ENSG00000101199 HEK293_OSMI2_2hA HEK293_TMG_2hB ARFGAP1 protein_coding protein_coding 77.33591 101.7141 56.3011 6.500943 2.455521 -0.8531706 32.996775 54.110910 17.697485 2.5003806 0.9943545 -1.6118268 0.40448750 0.53336667 0.3165 -0.21686667 2.236782e-05 2.617825e-30 FALSE TRUE
ENST00000395285 ENSG00000101199 HEK293_OSMI2_2hA HEK293_TMG_2hB ARFGAP1 protein_coding retained_intron 77.33591 101.7141 56.3011 6.500943 2.455521 -0.8531706 4.067639 3.145134 3.301941 0.7060235 0.3106963 0.0699760 0.05462500 0.03036667 0.0584 0.02803333 1.004406e-02 2.617825e-30 TRUE FALSE
ENST00000518794 ENSG00000101199 HEK293_OSMI2_2hA HEK293_TMG_2hB ARFGAP1 protein_coding processed_transcript 77.33591 101.7141 56.3011 6.500943 2.455521 -0.8531706 7.359210 6.979077 6.283775 1.0252374 0.1262942 -0.1511763 0.09751250 0.06806667 0.1120 0.04393333 1.519097e-02 2.617825e-30 FALSE FALSE
ENST00000519273 ENSG00000101199 HEK293_OSMI2_2hA HEK293_TMG_2hB ARFGAP1 protein_coding protein_coding 77.33591 101.7141 56.3011 6.500943 2.455521 -0.8531706 4.270705 5.394433 3.569395 1.0609599 0.6862049 -0.5944276 0.05663750 0.05223333 0.0626 0.01036667 7.509999e-01 2.617825e-30 FALSE TRUE
ENST00000519531 ENSG00000101199 HEK293_OSMI2_2hA HEK293_TMG_2hB ARFGAP1 protein_coding retained_intron 77.33591 101.7141 56.3011 6.500943 2.455521 -0.8531706 8.109718 5.797796 7.923856 1.0853536 0.3326465 0.4500315 0.11319167 0.05630000 0.1408 0.08450000 2.421304e-05 2.617825e-30 FALSE TRUE
ENST00000522959 ENSG00000101199 HEK293_OSMI2_2hA HEK293_TMG_2hB ARFGAP1 protein_coding retained_intron 77.33591 101.7141 56.3011 6.500943 2.455521 -0.8531706 6.243658 2.432066 7.955311 0.5309827 1.3323147 1.7056283 0.09231250 0.02366667 0.1398 0.11613333 5.838759e-08 2.617825e-30 FALSE FALSE
ENST00000549076 ENSG00000101199 HEK293_OSMI2_2hA HEK293_TMG_2hB ARFGAP1 protein_coding protein_coding 77.33591 101.7141 56.3011 6.500943 2.455521 -0.8531706 5.726634 17.164255 0.000000 2.5060894 0.0000000 -10.7460318 0.05981667 0.17030000 0.0000 -0.17030000 2.617825e-30 2.617825e-30 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000101199 E001 0.2214452 0.0371809228 1.000000e+00   20 63272513 63272784 272 + 0.000 0.088 8.559
ENSG00000101199 E002 0.2214452 0.0371809228 1.000000e+00   20 63272785 63272794 10 + 0.000 0.088 10.701
ENSG00000101199 E003 0.2214452 0.0371809228 1.000000e+00   20 63272795 63272796 2 + 0.000 0.088 10.701
ENSG00000101199 E004 0.3666179 0.0277755495 5.448106e-01 6.752323e-01 20 63272797 63272801 5 + 0.168 0.088 -1.077
ENSG00000101199 E005 1.3296188 0.0112184860 6.475352e-02 1.346419e-01 20 63272802 63272806 5 + 0.527 0.223 -1.816
ENSG00000101199 E006 2.6935912 0.0570851548 3.262677e-01 4.697199e-01 20 63272807 63272810 4 + 0.635 0.480 -0.713
ENSG00000101199 E007 5.0133018 0.0058215805 6.407156e-01 7.539186e-01 20 63272811 63272812 2 + 0.758 0.721 -0.153
ENSG00000101199 E008 6.6351639 0.0116981524 7.862425e-01 8.631001e-01 20 63272813 63272815 3 + 0.793 0.861 0.267
ENSG00000101199 E009 12.8242428 0.0304586130 9.603327e-01 9.790141e-01 20 63272816 63272824 9 + 1.075 1.113 0.138
ENSG00000101199 E010 28.5622979 0.0006879147 1.558332e-02 4.180872e-02 20 63272825 63272828 4 + 1.515 1.385 -0.446
ENSG00000101199 E011 38.6611770 0.0005793598 5.394324e-03 1.699944e-02 20 63272829 63272832 4 + 1.639 1.510 -0.443
ENSG00000101199 E012 102.2798786 0.0015604167 7.581611e-02 1.528042e-01 20 63272833 63272863 31 + 1.993 1.955 -0.129
ENSG00000101199 E013 102.5012246 0.0019888244 6.762288e-02 1.394055e-01 20 63272864 63272864 1 + 1.998 1.955 -0.143
ENSG00000101199 E014 146.6763909 0.0022148627 3.038144e-02 7.271211e-02 20 63272865 63272920 56 + 2.155 2.108 -0.157
ENSG00000101199 E015 1.4153691 0.1029575615 1.639308e-01 2.802710e-01 20 63273204 63273317 114 + 0.528 0.276 -1.419
ENSG00000101199 E016 1.6315183 0.0153172292 4.747261e-03 1.522523e-02 20 63273318 63273410 93 + 0.680 0.223 -2.500
ENSG00000101199 E017 1.0403201 0.1165325528 7.350369e-03 2.212890e-02 20 63273411 63273518 108 + 0.585 0.087 -3.677
ENSG00000101199 E018 2.7677383 0.1126017157 6.422163e-01 7.550514e-01 20 63274000 63274033 34 + 0.462 0.585 0.587
ENSG00000101199 E019 6.7200710 0.0026189998 9.537174e-01 9.750036e-01 20 63274034 63274170 137 + 0.825 0.848 0.090
ENSG00000101199 E020 3.9386412 0.0053323304 8.853990e-01 9.306940e-01 20 63274171 63274210 40 + 0.635 0.640 0.022
ENSG00000101199 E021 138.6233543 0.0016843998 1.988694e-04 9.589253e-04 20 63275577 63275622 46 + 2.168 2.066 -0.341
ENSG00000101199 E022 155.4840364 0.0016214186 1.688272e-04 8.301231e-04 20 63275623 63275640 18 + 2.214 2.117 -0.324
ENSG00000101199 E023 322.8399170 0.0011386770 1.828070e-05 1.144262e-04 20 63276091 63276200 110 + 2.514 2.439 -0.251
ENSG00000101199 E024 448.7021132 0.0016711299 5.173790e-03 1.640104e-02 20 63276480 63276651 172 + 2.629 2.594 -0.117
ENSG00000101199 E025 24.3770049 0.0047192182 1.658317e-20 1.126436e-18 20 63276652 63276742 91 + 1.721 1.045 -2.354
ENSG00000101199 E026 333.8712223 0.0006076068 2.083635e-01 3.365168e-01 20 63277205 63277305 101 + 2.470 2.477 0.022
ENSG00000101199 E027 381.6313677 0.0007058367 2.865912e-02 6.932751e-02 20 63278117 63278203 87 + 2.542 2.529 -0.045
ENSG00000101199 E028 23.9452241 0.0067945991 6.745486e-16 2.607984e-14 20 63278204 63278553 350 + 1.689 1.079 -2.121
ENSG00000101199 E029 410.0921732 0.0004490871 1.934970e-02 5.009103e-02 20 63278899 63278995 97 + 2.572 2.559 -0.042
ENSG00000101199 E030 2.4939409 0.0083533251 7.582656e-01 8.429044e-01 20 63279220 63279306 87 + 0.461 0.539 0.378
ENSG00000101199 E031 309.4510696 0.0020211025 1.715855e-01 2.902715e-01 20 63281291 63281347 57 + 2.443 2.441 -0.008
ENSG00000101199 E032 305.5610690 0.0050113408 8.480664e-01 9.056881e-01 20 63282819 63282851 33 + 2.412 2.447 0.115
ENSG00000101199 E033 158.8593682 0.0065474145 2.189346e-17 1.021086e-15 20 63282852 63283528 677 + 2.384 2.014 -1.237
ENSG00000101199 E034 38.7449547 0.0079692103 2.979964e-05 1.774685e-04 20 63283851 63283880 30 + 1.717 1.456 -0.889
ENSG00000101199 E035 70.2374331 0.0025087643 8.566737e-11 1.529779e-09 20 63284115 63284291 177 + 1.983 1.703 -0.944
ENSG00000101199 E036 30.4737276 0.0006992297 1.247371e-08 1.511422e-07 20 63284292 63284307 16 + 1.658 1.330 -1.127
ENSG00000101199 E037 61.3867536 0.0018792932 1.192844e-11 2.451516e-10 20 63284308 63284434 127 + 1.938 1.637 -1.015
ENSG00000101199 E038 57.4447562 0.0019253351 1.263260e-10 2.193190e-09 20 63284435 63284512 78 + 1.903 1.610 -0.992
ENSG00000101199 E039 126.5326245 0.0015295257 8.736108e-18 4.331404e-16 20 63284513 63284865 353 + 2.235 1.955 -0.937
ENSG00000101199 E040 388.3340772 0.0015819786 6.710308e-01 7.773677e-01 20 63284866 63284922 57 + 2.503 2.554 0.170
ENSG00000101199 E041 10.1798684 0.0066783077 3.904816e-06 2.846199e-05 20 63285486 63285653 168 + 1.279 0.819 -1.685
ENSG00000101199 E042 416.7449850 0.0012264688 4.038252e-01 5.476072e-01 20 63285654 63285713 60 + 2.527 2.587 0.199
ENSG00000101199 E043 33.6534704 0.0025255211 4.346403e-11 8.149377e-10 20 63285714 63285789 76 + 1.733 1.348 -1.318
ENSG00000101199 E044 48.2416786 0.0004689388 2.256481e-12 5.226599e-11 20 63285790 63285970 181 + 1.852 1.527 -1.100
ENSG00000101199 E045 21.7543113 0.0008677331 3.312057e-10 5.350552e-09 20 63285971 63285979 9 + 1.568 1.139 -1.495
ENSG00000101199 E046 61.3032305 0.0004064435 2.079567e-15 7.535726e-14 20 63285980 63286218 239 + 1.952 1.623 -1.111
ENSG00000101199 E047 46.0586441 0.0022118598 2.904773e-12 6.609422e-11 20 63286219 63286365 147 + 1.843 1.486 -1.211
ENSG00000101199 E048 261.6478254 0.0027342111 1.735194e-01 2.927642e-01 20 63286366 63286371 6 + 2.304 2.392 0.294
ENSG00000101199 E049 463.3741727 0.0015743425 5.760844e-02 1.225217e-01 20 63286372 63286442 71 + 2.550 2.640 0.301
ENSG00000101199 E050 483.5943194 0.0001747627 6.166256e-03 1.904960e-02 20 63287564 63287655 92 + 2.568 2.656 0.292
ENSG00000101199 E051 392.2339741 0.0003625805 8.540330e-03 2.514008e-02 20 63287656 63287747 92 + 2.473 2.567 0.313
ENSG00000101199 E052 912.5298222 0.0002055190 5.289974e-03 1.672122e-02 20 63287748 63288309 562 + 2.855 2.931 0.254
ENSG00000101199 E053 2447.2711188 0.0024264555 1.295423e-12 3.117953e-11 20 63288310 63289496 1187 + 3.199 3.388 0.627
ENSG00000101199 E054 425.6238330 0.0045956793 2.901549e-09 3.949772e-08 20 63289497 63289677 181 + 2.374 2.645 0.902
ENSG00000101199 E055 194.6348111 0.0042574598 1.538339e-09 2.203158e-08 20 63289678 63289790 113 + 2.002 2.313 1.042