ENSG00000101191

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000266070 ENSG00000101191 HEK293_OSMI2_2hA HEK293_TMG_2hB DIDO1 protein_coding protein_coding 24.19591 19.31802 24.27176 0.9259754 0.3479646 0.3291792 10.903662 9.4402110 16.405458 0.8924545 0.3236814 0.7966366 0.4608542 0.48636667 0.67580000 0.18943333 1.954800e-06 1.9548e-06 FALSE TRUE
ENST00000354665 ENSG00000101191 HEK293_OSMI2_2hA HEK293_TMG_2hB DIDO1 protein_coding protein_coding 24.19591 19.31802 24.27176 0.9259754 0.3479646 0.3291792 4.933451 5.0339614 3.605751 0.7472013 0.6140516 -0.4802620 0.2057625 0.25816667 0.14866667 -0.10950000 1.153607e-01 1.9548e-06 FALSE TRUE
ENST00000370371 ENSG00000101191 HEK293_OSMI2_2hA HEK293_TMG_2hB DIDO1 protein_coding protein_coding 24.19591 19.31802 24.27176 0.9259754 0.3479646 0.3291792 2.389818 0.5760595 1.155174 0.5760595 0.5666228 0.9914266 0.0910375 0.03296667 0.04763333 0.01466667 3.640340e-01 1.9548e-06 FALSE TRUE
ENST00000395340 ENSG00000101191 HEK293_OSMI2_2hA HEK293_TMG_2hB DIDO1 protein_coding protein_coding 24.19591 19.31802 24.27176 0.9259754 0.3479646 0.3291792 5.397659 4.0126163 2.877702 0.1883449 0.1212033 -0.4782123 0.2195417 0.20806667 0.11856667 -0.08950000 3.919499e-05 1.9548e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000101191 E001 0.7405235 0.0164943085 8.562066e-01 9.110892e-01 20 62876046 62877737 1692 - 0.263 0.246 -0.133
ENSG00000101191 E002 0.9963223 0.0248533057 3.851899e-03 1.272629e-02 20 62877738 62877742 5 - 0.000 0.516 12.369
ENSG00000101191 E003 1771.9355971 0.0008743448 8.885226e-05 4.696650e-04 20 62877743 62882414 4672 - 3.206 3.288 0.273
ENSG00000101191 E004 396.6117130 0.0051311381 3.492571e-33 7.451094e-31 20 62887214 62890434 3221 - 2.297 2.793 1.653
ENSG00000101191 E005 40.0244304 0.0005651703 2.933644e-08 3.307171e-07 20 62890435 62890690 256 - 1.411 1.756 1.180
ENSG00000101191 E006 13.8979051 0.0104166190 1.756025e-01 2.954710e-01 20 62890691 62890719 29 - 1.084 1.250 0.593
ENSG00000101191 E007 39.9694600 0.0062902020 2.306055e-05 1.409320e-04 20 62890720 62890959 240 - 1.424 1.745 1.092
ENSG00000101191 E008 170.0810498 0.0045487568 2.524570e-03 8.836111e-03 20 62890960 62891155 196 - 2.271 2.178 -0.312
ENSG00000101191 E009 115.6512266 0.0015873895 4.194355e-05 2.405789e-04 20 62891987 62892076 90 - 2.118 1.994 -0.414
ENSG00000101191 E010 161.8265861 0.0003921415 2.918640e-12 6.636989e-11 20 62892809 62892962 154 - 2.283 2.111 -0.577
ENSG00000101191 E011 282.1139010 0.0001775509 4.524766e-11 8.457017e-10 20 62893666 62894194 529 - 2.497 2.386 -0.367
ENSG00000101191 E012 103.5513672 0.0003010159 1.643646e-04 8.108319e-04 20 62894413 62894548 136 - 2.061 1.959 -0.341
ENSG00000101191 E013 103.1984681 0.0014789393 6.140748e-08 6.499868e-07 20 62894810 62894914 105 - 2.091 1.907 -0.616
ENSG00000101191 E014 109.6569578 0.0003320958 1.510838e-06 1.207237e-05 20 62895049 62895165 117 - 2.101 1.966 -0.452
ENSG00000101191 E015 129.7678830 0.0020369008 3.755606e-07 3.404087e-06 20 62896233 62896392 160 - 2.183 2.023 -0.538
ENSG00000101191 E016 192.5698804 0.0002702390 3.941792e-15 1.377533e-13 20 62896531 62896996 466 - 2.357 2.180 -0.593
ENSG00000101191 E017 2.1193714 0.1504152069 3.277816e-01 4.712476e-01 20 62904998 62905002 5 - 0.379 0.603 1.107
ENSG00000101191 E018 2.4149136 0.1374797442 3.666160e-01 5.109628e-01 20 62905003 62905004 2 - 0.427 0.640 1.008
ENSG00000101191 E019 2.9663564 0.0733712952 1.132573e-01 2.102771e-01 20 62905005 62905005 1 - 0.427 0.743 1.438
ENSG00000101191 E020 119.6972779 0.0145799824 3.143918e-14 9.617404e-13 20 62905006 62905601 596 - 1.733 2.293 1.877
ENSG00000101191 E021 80.7040926 0.0006116565 1.942350e-25 2.219375e-23 20 62905602 62905886 285 - 1.628 2.098 1.585
ENSG00000101191 E022 185.6441077 0.0045927919 9.601276e-01 9.789089e-01 20 62905887 62906100 214 - 2.252 2.287 0.117
ENSG00000101191 E023 188.0323216 0.0041662709 9.340036e-01 9.624221e-01 20 62907147 62907359 213 - 2.260 2.289 0.100
ENSG00000101191 E024 1.4308980 0.0137773430 5.235097e-01 6.571894e-01 20 62909051 62909158 108 - 0.426 0.331 -0.544
ENSG00000101191 E025 284.7868974 0.0028377398 3.587284e-02 8.333642e-02 20 62909699 62910020 322 - 2.470 2.436 -0.113
ENSG00000101191 E026 489.0703417 0.0085703920 4.571291e-03 1.474074e-02 20 62910774 62911614 841 - 2.728 2.640 -0.294
ENSG00000101191 E027 188.2957501 0.0075226185 1.684019e-05 1.062238e-04 20 62914210 62914406 197 - 2.349 2.172 -0.591
ENSG00000101191 E028 14.5613045 0.0272291320 6.602756e-01 7.689678e-01 20 62926432 62926438 7 - 1.197 1.172 -0.091
ENSG00000101191 E029 21.9780117 0.0258838497 8.378015e-01 8.985958e-01 20 62926439 62926505 67 - 1.356 1.359 0.010
ENSG00000101191 E030 75.1953049 0.0013198930 3.613164e-12 8.085319e-11 20 62937796 62937952 157 - 1.991 1.707 -0.958