ENSG00000101144

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000395863 ENSG00000101144 HEK293_OSMI2_2hA HEK293_TMG_2hB BMP7 protein_coding protein_coding 26.82239 40.45653 19.8947 2.682769 0.7087621 -1.02362 11.914534 13.938079 9.595873 0.1428695 0.1927726 -0.5380778 0.46552917 0.3473667 0.4842333 0.13686667 2.180772e-02 1.279944e-51 FALSE TRUE
ENST00000395864 ENSG00000101144 HEK293_OSMI2_2hA HEK293_TMG_2hB BMP7 protein_coding protein_coding 26.82239 40.45653 19.8947 2.682769 0.7087621 -1.02362 3.902441 6.829422 2.278811 0.7781070 0.4646304 -1.5792762 0.13386667 0.1681667 0.1160333 -0.05213333 4.276133e-01 1.279944e-51 FALSE TRUE
ENST00000460817 ENSG00000101144 HEK293_OSMI2_2hA HEK293_TMG_2hB BMP7 protein_coding processed_transcript 26.82239 40.45653 19.8947 2.682769 0.7087621 -1.02362 2.491744 7.581976 0.000000 0.7417929 0.0000000 -9.5683316 0.07381667 0.1866667 0.0000000 -0.18666667 1.279944e-51 1.279944e-51 FALSE FALSE
MSTRG.20888.1 ENSG00000101144 HEK293_OSMI2_2hA HEK293_TMG_2hB BMP7 protein_coding   26.82239 40.45653 19.8947 2.682769 0.7087621 -1.02362 6.318681 9.285119 6.274162 0.9769654 1.3571312 -0.5647530 0.24390833 0.2282667 0.3115333 0.08326667 4.701477e-01 1.279944e-51 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000101144 E001 0.2214452 0.0387896920 1.000000e+00   20 57159656 57159807 152 - 0.000 0.089 8.304
ENSG00000101144 E002 511.7904693 0.0031071517 7.090686e-04 2.931581e-03 20 57168753 57170530 1778 - 2.743 2.631 -0.370
ENSG00000101144 E003 147.3520798 0.0002238593 4.088644e-02 9.267876e-02 20 57170531 57170640 110 - 2.091 2.139 0.161
ENSG00000101144 E004 509.5594373 0.0001264216 5.794584e-07 5.065134e-06 20 57170641 57170916 276 - 2.614 2.681 0.223
ENSG00000101144 E005 356.8333032 0.0002250972 1.272957e-02 3.527609e-02 20 57170917 57171038 122 - 2.485 2.519 0.114
ENSG00000101144 E006 270.2204132 0.0002198275 4.578757e-02 1.016466e-01 20 57171039 57171108 70 - 2.368 2.398 0.099
ENSG00000101144 E007 2.3613665 0.2256446899 5.156844e-01 6.503155e-01 20 57172996 57173199 204 - 0.381 0.555 0.882
ENSG00000101144 E008 172.5002643 0.0008029151 3.089806e-01 4.512655e-01 20 57173200 57173219 20 - 2.185 2.201 0.051
ENSG00000101144 E009 246.4791924 0.0002148366 2.042488e-01 3.314800e-01 20 57173220 57173310 91 - 2.339 2.353 0.047
ENSG00000101144 E010 1.5479686 0.0097996271 5.053518e-01 6.411569e-01 20 57173311 57173589 279 - 0.458 0.329 -0.719
ENSG00000101144 E011 226.0282811 0.0001976292 8.729502e-03 2.560940e-02 20 57174931 57175007 77 - 2.273 2.323 0.168
ENSG00000101144 E012 0.3299976 0.0276644533 4.570231e-01   20 57177696 57178037 342 - 0.000 0.162 9.297
ENSG00000101144 E013 365.2102299 0.0025636516 5.531424e-01 6.823319e-01 20 57183722 57183919 198 - 2.519 2.519 0.000
ENSG00000101144 E014 1.4393276 0.0328580286 6.091935e-01 7.287174e-01 20 57187050 57187156 107 - 0.287 0.374 0.547
ENSG00000101144 E015 1.9896259 0.0081447484 5.271098e-01 6.602622e-01 20 57202474 57202474 1 - 0.380 0.483 0.541
ENSG00000101144 E016 316.1175062 0.0059629967 9.368977e-01 9.643237e-01 20 57202475 57202623 149 - 2.466 2.452 -0.046
ENSG00000101144 E017 0.0000000       20 57224575 57224685 111 -      
ENSG00000101144 E018 0.0000000       20 57224760 57224840 81 -      
ENSG00000101144 E019 0.3332198 0.0284416383 6.184060e-01   20 57225855 57225962 108 - 0.166 0.089 -1.042
ENSG00000101144 E020 368.8662589 0.0001828690 3.076816e-03 1.049219e-02 20 57228229 57228421 193 - 2.573 2.498 -0.248
ENSG00000101144 E021 0.0000000       20 57243864 57244034 171 -      
ENSG00000101144 E022 438.2697689 0.0032111768 1.758845e-03 6.468172e-03 20 57265705 57266641 937 - 2.672 2.564 -0.361