ENSG00000101138

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000217109 ENSG00000101138 HEK293_OSMI2_2hA HEK293_TMG_2hB CSTF1 protein_coding protein_coding 23.0831 16.53266 32.72413 2.225148 1.071784 0.9846044 7.280746 7.5436788 8.815324 1.58068296 0.1555226 0.2244698 0.33587917 0.4489333 0.26986667 -0.179066667 0.0009090817 0.0009090817 FALSE TRUE
ENST00000415828 ENSG00000101138 HEK293_OSMI2_2hA HEK293_TMG_2hB CSTF1 protein_coding protein_coding 23.0831 16.53266 32.72413 2.225148 1.071784 0.9846044 8.953849 5.5127390 12.731965 0.70964435 0.4154289 1.2061319 0.37835833 0.3351667 0.39076667 0.055600000 0.5517354081 0.0009090817 FALSE TRUE
ENST00000452950 ENSG00000101138 HEK293_OSMI2_2hA HEK293_TMG_2hB CSTF1 protein_coding protein_coding 23.0831 16.53266 32.72413 2.225148 1.071784 0.9846044 4.122190 2.3079247 6.850074 0.21220259 0.9427402 1.5653904 0.17196667 0.1415333 0.20793333 0.066400000 0.1637474885 0.0009090817 FALSE TRUE
ENST00000613138 ENSG00000101138 HEK293_OSMI2_2hA HEK293_TMG_2hB CSTF1 protein_coding processed_transcript 23.0831 16.53266 32.72413 2.225148 1.071784 0.9846044 1.162321 0.7963095 1.676875 0.09371979 0.2463260 1.0649473 0.05139167 0.0493000 0.05083333 0.001533333 0.9528671203 0.0009090817   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000101138 E001 0.4396707 0.0272115547 1.482705e-01 2.593234e-01 20 56392371 56392376 6 + 0.254 0.000 -9.989
ENSG00000101138 E002 8.5605402 0.0066469597 1.834874e-04 8.928450e-04 20 56392377 56392410 34 + 1.120 0.699 -1.609
ENSG00000101138 E003 34.4433302 0.0099740529 2.017991e-02 5.185940e-02 20 56392411 56392521 111 + 1.605 1.462 -0.488
ENSG00000101138 E004 27.8640652 0.0298734648 1.635175e-01 2.797203e-01 20 56392522 56392538 17 + 1.506 1.386 -0.412
ENSG00000101138 E005 10.2265156 0.0018554163 7.758449e-01 8.556280e-01 20 56392539 56392644 106 + 1.012 1.086 0.271
ENSG00000101138 E006 11.1753621 0.0137010178 8.050887e-01 8.759922e-01 20 56392645 56392650 6 + 1.075 1.086 0.043
ENSG00000101138 E007 30.9398916 0.0006691754 1.444206e-01 2.540442e-01 20 56392651 56392682 32 + 1.523 1.479 -0.149
ENSG00000101138 E008 50.3107659 0.0060004574 1.593848e-01 2.742927e-01 20 56392683 56392694 12 + 1.730 1.682 -0.163
ENSG00000101138 E009 64.7147640 0.0004392795 3.217056e-01 4.649513e-01 20 56392695 56392713 19 + 1.817 1.823 0.018
ENSG00000101138 E010 18.4716725 0.0013712782 3.107543e-04 1.423254e-03 20 56392714 56392815 102 + 1.381 1.127 -0.896
ENSG00000101138 E011 110.1788411 0.0085235801 2.884563e-01 4.290563e-01 20 56395521 56395552 32 + 2.056 2.029 -0.088
ENSG00000101138 E012 195.5057018 0.0054760790 7.123807e-03 2.154646e-02 20 56395553 56395721 169 + 2.325 2.248 -0.258
ENSG00000101138 E013 6.1228340 0.0027422516 2.052198e-04 9.863575e-04 20 56395722 56395759 38 + 1.000 0.531 -1.910
ENSG00000101138 E014 7.2093514 0.0022844522 5.193116e-05 2.913728e-04 20 56395760 56395937 178 + 1.064 0.579 -1.922
ENSG00000101138 E015 6.9380828 0.1053654276 3.052210e-03 1.041944e-02 20 56396918 56397206 289 + 1.072 0.478 -2.431
ENSG00000101138 E016 287.8166610 0.0004896548 3.278887e-07 3.009570e-06 20 56397207 56397484 278 + 2.491 2.428 -0.209
ENSG00000101138 E017 239.6324676 0.0002368981 1.944491e-01 3.193373e-01 20 56397644 56397841 198 + 2.377 2.398 0.069
ENSG00000101138 E018 372.4094330 0.0027410679 1.813194e-01 3.028978e-01 20 56398967 56399357 391 + 2.535 2.619 0.281
ENSG00000101138 E019 621.2977777 0.0053103795 5.217927e-07 4.598626e-06 20 56403468 56406362 2895 + 2.699 2.888 0.630