ENSG00000101057

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000217026 ENSG00000101057 HEK293_OSMI2_2hA HEK293_TMG_2hB MYBL2 protein_coding protein_coding 273.8858 490.1041 176.6471 15.35627 2.459452 -1.472166 73.505005 83.79676 81.06209 12.46552 2.959604 -0.04786134 0.28050833 0.16993333 0.4589333 0.28900000 6.101946e-10 7.494578e-46 FALSE TRUE
MSTRG.20728.33 ENSG00000101057 HEK293_OSMI2_2hA HEK293_TMG_2hB MYBL2 protein_coding   273.8858 490.1041 176.6471 15.35627 2.459452 -1.472166 159.663010 320.83233 73.07264 26.08036 3.364894 -2.13426390 0.58111667 0.65253333 0.4136333 -0.23890000 4.280885e-05 7.494578e-46 FALSE TRUE
MSTRG.20728.42 ENSG00000101057 HEK293_OSMI2_2hA HEK293_TMG_2hB MYBL2 protein_coding   273.8858 490.1041 176.6471 15.35627 2.459452 -1.472166 8.849458 36.25615 0.00000 24.98740 0.000000 -11.82440774 0.01879583 0.07716667 0.0000000 -0.07716667 2.252440e-01 7.494578e-46 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000101057 E001 1.7597602 0.0079261069 2.200095e-01 3.504212e-01 20 43657990 43658022 33 + 0.190 0.437 1.658
ENSG00000101057 E002 1.3566106 0.0097899198 3.688421e-01 5.132561e-01 20 43658023 43658036 14 + 0.190 0.371 1.294
ENSG00000101057 E003 0.9117310 0.1477306262 8.062888e-01 8.768630e-01 20 43658037 43658071 35 + 0.190 0.251 0.509
ENSG00000101057 E004 0.0000000       20 43667019 43667030 12 +      
ENSG00000101057 E005 0.8512514 0.0144249142 7.811387e-01 8.593860e-01 20 43667031 43667039 9 + 0.190 0.248 0.487
ENSG00000101057 E006 1.5908299 0.0097231375 6.068302e-01 7.269001e-01 20 43667040 43667041 2 + 0.423 0.334 -0.511
ENSG00000101057 E007 3.0883599 0.0050678148 8.303303e-01 8.935369e-01 20 43667042 43667051 10 + 0.574 0.545 -0.134
ENSG00000101057 E008 3.0883599 0.0050678148 8.303303e-01 8.935369e-01 20 43667052 43667053 2 + 0.574 0.545 -0.134
ENSG00000101057 E009 3.2398753 0.0050215320 5.594130e-01 6.875102e-01 20 43667054 43667057 4 + 0.633 0.545 -0.397
ENSG00000101057 E010 5.2920452 0.0083434356 2.366854e-01 3.703465e-01 20 43667058 43667064 7 + 0.848 0.687 -0.648
ENSG00000101057 E011 9.2057008 0.0020465752 1.169350e-04 5.997992e-04 20 43667065 43667085 21 + 1.215 0.806 -1.512
ENSG00000101057 E012 9.8721405 0.0035622252 8.409086e-05 4.474430e-04 20 43667086 43667086 1 + 1.243 0.831 -1.512
ENSG00000101057 E013 12.2670835 0.0014312597 1.499571e-06 1.199397e-05 20 43667087 43667090 4 + 1.351 0.900 -1.628
ENSG00000101057 E014 15.1140065 0.0059263265 4.507038e-10 7.117560e-09 20 43667091 43667093 3 + 1.494 0.930 -2.007
ENSG00000101057 E015 25.4619566 0.0010797064 1.663217e-24 1.735086e-22 20 43667094 43667105 12 + 1.765 1.072 -2.405
ENSG00000101057 E016 29.0037960 0.0045122509 8.136102e-24 7.917032e-22 20 43667106 43667107 2 + 1.822 1.119 -2.428
ENSG00000101057 E017 32.9791659 0.0039013519 3.849686e-29 6.007507e-27 20 43667108 43667110 3 + 1.889 1.150 -2.541
ENSG00000101057 E018 38.2455571 0.0048270168 5.045668e-31 9.103682e-29 20 43667111 43667113 3 + 1.952 1.207 -2.551
ENSG00000101057 E019 462.8647864 0.0098857171 6.767291e-15 2.290870e-13 20 43667114 43667303 190 + 2.852 2.466 -1.286
ENSG00000101057 E020 0.6652806 0.0188281499 1.000000e+00 1.000000e+00 20 43669523 43669556 34 + 0.190 0.198 0.071
ENSG00000101057 E021 0.3289534 0.0274424043 4.349913e-01   20 43671340 43671342 3 + 0.190 0.077 -1.512
ENSG00000101057 E022 0.9190056 0.0236603524 6.711102e-01 7.774281e-01 20 43671343 43671373 31 + 0.322 0.247 -0.518
ENSG00000101057 E023 0.9190056 0.0236603524 6.711102e-01 7.774281e-01 20 43671374 43671374 1 + 0.322 0.247 -0.518
ENSG00000101057 E024 2.2003759 0.1336366053 4.671026e-01 6.066151e-01 20 43671375 43671433 59 + 0.573 0.430 -0.696
ENSG00000101057 E025 3.6807530 0.0713104931 7.233778e-02 1.472348e-01 20 43673708 43673805 98 + 0.812 0.501 -1.339
ENSG00000101057 E026 1234.7099848 0.0016799346 9.838822e-16 3.717462e-14 20 43673806 43673899 94 + 3.137 2.968 -0.559
ENSG00000101057 E027 1658.2255558 0.0013776020 9.418617e-11 1.669157e-09 20 43681784 43681855 72 + 3.228 3.111 -0.390
ENSG00000101057 E028 2252.0191494 0.0016236272 1.549603e-06 1.234619e-05 20 43682794 43682886 93 + 3.339 3.253 -0.286
ENSG00000101057 E029 24.8495072 0.0172354805 2.632430e-01 4.011212e-01 20 43682887 43682915 29 + 1.401 1.305 -0.334
ENSG00000101057 E030 3592.0183126 0.0025075954 1.535853e-03 5.752866e-03 20 43686852 43687072 221 + 3.523 3.462 -0.202
ENSG00000101057 E031 2.8366850 0.0667886131 9.726116e-01 9.869146e-01 20 43690251 43690348 98 + 0.505 0.523 0.086
ENSG00000101057 E032 0.1817044 0.0392531980 1.000000e+00   20 43691053 43691106 54 + 0.000 0.077 7.613
ENSG00000101057 E033 15.5937880 0.0150283239 7.602197e-01 8.443880e-01 20 43692121 43692135 15 + 1.152 1.130 -0.081
ENSG00000101057 E034 21.9796343 0.0583878854 7.142445e-01 8.105207e-01 20 43692136 43692156 21 + 1.319 1.270 -0.172
ENSG00000101057 E035 2823.0930135 0.0013052591 6.724956e-03 2.050807e-02 20 43692157 43692319 163 + 3.400 3.363 -0.121
ENSG00000101057 E036 1.4694173 0.1151381055 6.208523e-01 7.379096e-01 20 43698288 43698327 40 + 0.423 0.332 -0.523
ENSG00000101057 E037 3930.1271465 0.0003135887 3.518727e-08 3.907000e-07 20 43699757 43700044 288 + 3.548 3.504 -0.145
ENSG00000101057 E038 4990.0028124 0.0000321703 3.394432e-04 1.538175e-03 20 43702490 43702903 414 + 3.626 3.615 -0.037
ENSG00000101057 E039 1409.5233813 0.0002226365 5.374384e-01 6.689977e-01 20 43705219 43705242 24 + 3.068 3.071 0.009
ENSG00000101057 E040 2608.0685049 0.0003245927 5.831857e-01 7.073503e-01 20 43705243 43705358 116 + 3.333 3.338 0.019
ENSG00000101057 E041 2815.7780814 0.0006363603 9.279537e-01 9.586428e-01 20 43709963 43710062 100 + 3.360 3.374 0.047
ENSG00000101057 E042 143.6117325 0.0013131004 5.903998e-04 2.498614e-03 20 43710326 43710810 485 + 1.957 2.108 0.506
ENSG00000101057 E043 37.9498134 0.0005741804 1.228853e-01 2.240727e-01 20 43711443 43711487 45 + 1.420 1.536 0.399
ENSG00000101057 E044 3329.0824357 0.0005928397 3.045120e-02 7.284501e-02 20 43711488 43711601 114 + 3.411 3.453 0.137
ENSG00000101057 E045 3433.6473398 0.0004955063 5.133956e-12 1.121413e-10 20 43713002 43713106 105 + 3.378 3.477 0.329
ENSG00000101057 E046 4191.9709281 0.0007293145 3.408461e-15 1.202239e-13 20 43715134 43715283 150 + 3.446 3.569 0.408
ENSG00000101057 E047 6179.8655532 0.0012484177 1.065007e-32 2.183576e-30 20 43715959 43716495 537 + 3.541 3.752 0.700