ENSG00000101052

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373030 ENSG00000101052 HEK293_OSMI2_2hA HEK293_TMG_2hB IFT52 protein_coding protein_coding 30.83588 22.43366 45.36694 4.228193 0.7532619 1.015652 18.839035 10.336195 29.199621 2.2516798 0.6352553 1.49734341 0.6105208 0.45806667 0.6444333 0.18636667 0.018186833 0.005103607 FALSE TRUE
ENST00000373039 ENSG00000101052 HEK293_OSMI2_2hA HEK293_TMG_2hB IFT52 protein_coding protein_coding 30.83588 22.43366 45.36694 4.228193 0.7532619 1.015652 7.644664 9.038781 8.892081 1.7356549 1.6267097 -0.02358081 0.2428375 0.40490000 0.1949667 -0.20993333 0.005103607 0.005103607 FALSE TRUE
MSTRG.20742.1 ENSG00000101052 HEK293_OSMI2_2hA HEK293_TMG_2hB IFT52 protein_coding   30.83588 22.43366 45.36694 4.228193 0.7532619 1.015652 3.209495 2.086270 6.061669 0.2572374 0.3460379 1.53426886 0.1034375 0.09556667 0.1339333 0.03836667 0.165144035 0.005103607 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000101052 E001 57.3457375 0.0031045600 3.395434e-05 1.992797e-04 20 43590937 43590989 53 + 1.844 1.601 -0.821
ENSG00000101052 E002 108.1226856 0.0047740760 3.322732e-05 1.954245e-04 20 43590990 43591029 40 + 2.109 1.889 -0.739
ENSG00000101052 E003 65.7601234 0.0004023469 8.500921e-07 7.169771e-06 20 43591030 43591054 25 + 1.901 1.670 -0.781
ENSG00000101052 E004 123.9890074 0.0031150696 1.633943e-04 8.065916e-04 20 43594693 43594721 29 + 2.155 1.981 -0.581
ENSG00000101052 E005 211.1866859 0.0050590472 1.108241e-02 3.136435e-02 20 43594722 43594817 96 + 2.368 2.243 -0.417
ENSG00000101052 E006 184.7495984 0.0033043225 1.628680e-01 2.788838e-01 20 43596435 43596522 88 + 2.290 2.223 -0.225
ENSG00000101052 E007 222.8512228 0.0002871453 9.693832e-01 9.848666e-01 20 43603760 43603873 114 + 2.350 2.346 -0.011
ENSG00000101052 E008 101.3015904 0.0002937558 2.700230e-01 4.085932e-01 20 43603874 43603889 16 + 1.993 2.031 0.128
ENSG00000101052 E009 178.3444454 0.0004932174 7.943804e-01 8.686307e-01 20 43604183 43604258 76 + 2.251 2.257 0.019
ENSG00000101052 E010 195.8699390 0.0002325206 9.691680e-01 9.847200e-01 20 43605002 43605073 72 + 2.294 2.294 0.001
ENSG00000101052 E011 4.1050256 0.0039736458 5.404181e-01 6.715683e-01 20 43605074 43605216 143 + 0.737 0.646 -0.379
ENSG00000101052 E012 168.1388697 0.0002329408 8.611964e-01 9.144522e-01 20 43613850 43613898 49 + 2.230 2.225 -0.019
ENSG00000101052 E013 203.9701020 0.0001926424 4.386379e-01 5.805126e-01 20 43613899 43613965 67 + 2.319 2.299 -0.068
ENSG00000101052 E014 126.6909237 0.0004288042 7.136086e-02 1.455905e-01 20 43613966 43613976 11 + 2.127 2.066 -0.205
ENSG00000101052 E015 4.4372013 0.0036620615 3.807752e-01 5.250680e-01 20 43618241 43618242 2 + 0.774 0.646 -0.531
ENSG00000101052 E016 10.5693942 0.0016798933 2.555588e-01 3.924584e-01 20 43618243 43618353 111 + 1.101 0.981 -0.442
ENSG00000101052 E017 230.9723720 0.0001899000 1.079148e-01 2.024411e-01 20 43618940 43619026 87 + 2.382 2.343 -0.130
ENSG00000101052 E018 220.5743078 0.0002618751 4.081640e-01 5.517490e-01 20 43620857 43620925 69 + 2.354 2.333 -0.073
ENSG00000101052 E019 0.1515154 0.0436220408 9.018183e-01   20 43620926 43621058 133 + 0.096 0.000 -7.793
ENSG00000101052 E020 323.8219009 0.0001869841 5.966216e-01 7.185288e-01 20 43623891 43624045 155 + 2.508 2.517 0.031
ENSG00000101052 E021 0.9650892 0.0138483677 1.437427e-01 2.531125e-01 20 43624046 43624122 77 + 0.175 0.433 1.789
ENSG00000101052 E022 267.4516348 0.0001652569 1.405958e-01 2.488435e-01 20 43635926 43636013 88 + 2.417 2.448 0.104
ENSG00000101052 E023 124.4886050 0.0002831197 6.139861e-02 1.289880e-01 20 43637145 43637146 2 + 2.075 2.134 0.198
ENSG00000101052 E024 247.9103742 0.0002299582 6.590737e-05 3.603762e-04 20 43637147 43637253 107 + 2.359 2.449 0.301
ENSG00000101052 E025 1.9270605 0.0133446948 6.488232e-01 7.602655e-01 20 43642158 43642478 321 + 0.509 0.432 -0.383
ENSG00000101052 E026 314.8791760 0.0015942164 5.227118e-05 2.931330e-04 20 43642479 43642624 146 + 2.452 2.561 0.363
ENSG00000101052 E027 258.9514094 0.0011081999 6.083448e-11 1.110835e-09 20 43646936 43647299 364 + 2.337 2.509 0.572