ENSG00000101040

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360911 ENSG00000101040 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYND8 protein_coding protein_coding 9.3564 7.354574 10.59554 0.5527296 0.1140474 0.5261442 4.0226561 3.7717143 3.952968 0.41266224 0.1852177 0.06754107 0.43943333 0.5104667 0.3729333 -0.1375333 8.809509e-03 3.841869e-16 FALSE TRUE
ENST00000372023 ENSG00000101040 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYND8 protein_coding protein_coding 9.3564 7.354574 10.59554 0.5527296 0.1140474 0.5261442 0.4680159 0.8220404 0.000000 0.06345593 0.0000000 -6.37858173 0.04843750 0.1134667 0.0000000 -0.1134667 3.841869e-16 3.841869e-16 FALSE TRUE
ENST00000467200 ENSG00000101040 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYND8 protein_coding protein_coding 9.3564 7.354574 10.59554 0.5527296 0.1140474 0.5261442 0.9510530 0.0000000 2.237156 0.00000000 0.3861346 7.81195652 0.08764583 0.0000000 0.2107000 0.2107000 2.838984e-14 3.841869e-16 FALSE TRUE
ENST00000536340 ENSG00000101040 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYND8 protein_coding protein_coding 9.3564 7.354574 10.59554 0.5527296 0.1140474 0.5261442 1.7454601 2.3122837 1.345248 0.22821397 0.5012208 -0.77698755 0.19627083 0.3157333 0.1273333 -0.1884000 5.035192e-02 3.841869e-16 FALSE TRUE
ENST00000611941 ENSG00000101040 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYND8 protein_coding protein_coding 9.3564 7.354574 10.59554 0.5527296 0.1140474 0.5261442 1.1894496 0.1656150 1.475376 0.16561503 0.7422578 3.08033949 0.13075833 0.0257000 0.1389000 0.1132000 5.361976e-01 3.841869e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000101040 E001 307.9320667 0.0111803852 6.053197e-08 6.412929e-07 20 47209214 47210246 1033 - 2.317 2.624 1.025
ENSG00000101040 E002 81.9855555 0.0037830651 2.822154e-09 3.850547e-08 20 47210247 47210412 166 - 1.737 2.061 1.087
ENSG00000101040 E003 16.8930816 0.0012796038 1.283714e-07 1.276953e-06 20 47210413 47210440 28 - 0.948 1.438 1.748
ENSG00000101040 E004 44.8873382 0.0005948217 9.000470e-09 1.118840e-07 20 47210441 47210559 119 - 1.459 1.801 1.164
ENSG00000101040 E005 49.2458524 0.0004925261 7.280390e-06 4.991484e-05 20 47210560 47210596 37 - 1.554 1.814 0.882
ENSG00000101040 E006 100.0643632 0.0046394930 2.316450e-04 1.098457e-03 20 47210597 47210760 164 - 1.889 2.098 0.702
ENSG00000101040 E007 96.6650634 0.0045708543 8.358078e-02 1.651487e-01 20 47210761 47210897 137 - 1.926 2.043 0.391
ENSG00000101040 E008 40.9119921 0.0051801832 5.047501e-01 6.406455e-01 20 47212642 47212725 84 - 1.623 1.614 -0.031
ENSG00000101040 E009 54.3167541 0.0070748758 8.377962e-01 8.985958e-01 20 47220258 47220324 67 - 1.719 1.764 0.154
ENSG00000101040 E010 77.7585280 0.0003807781 5.761035e-01 7.015922e-01 20 47221314 47221474 161 - 1.889 1.900 0.039
ENSG00000101040 E011 99.3346477 0.0003925827 8.323441e-01 8.949516e-01 20 47224317 47224556 240 - 1.986 2.012 0.090
ENSG00000101040 E012 63.6208737 0.0004450127 7.992505e-01 8.719636e-01 20 47227203 47227281 79 - 1.786 1.831 0.152
ENSG00000101040 E013 66.1833681 0.0003961904 3.439290e-01 4.879841e-01 20 47229726 47229806 81 - 1.826 1.819 -0.024
ENSG00000101040 E014 84.1012868 0.0003725735 1.148917e-01 2.126842e-01 20 47236326 47236516 191 - 1.939 1.912 -0.090
ENSG00000101040 E015 1.2714440 0.1469281175 1.027346e-01 1.946647e-01 20 47237310 47238757 1448 - 0.473 0.140 -2.372
ENSG00000101040 E016 7.8077369 0.0099576929 4.067269e-01 5.503446e-01 20 47238758 47238895 138 - 0.873 1.003 0.488
ENSG00000101040 E017 74.9292211 0.0057694407 6.077068e-01 7.276097e-01 20 47238896 47239138 243 - 1.875 1.881 0.020
ENSG00000101040 E018 50.6322808 0.0110519331 8.556530e-01 9.107479e-01 20 47246008 47246092 85 - 1.686 1.732 0.155
ENSG00000101040 E019 143.0820958 0.0002830500 1.055973e-01 1.990082e-01 20 47246093 47246517 425 - 2.161 2.148 -0.045
ENSG00000101040 E020 75.1378991 0.0091433538 1.973473e-01 3.229128e-01 20 47249287 47249439 153 - 1.900 1.860 -0.135
ENSG00000101040 E021 70.1477286 0.0045209222 3.968420e-03 1.305399e-02 20 47262288 47262428 141 - 1.903 1.786 -0.394
ENSG00000101040 E022 117.9505857 0.0023421851 3.247816e-03 1.099516e-02 20 47276314 47276795 482 - 2.110 2.030 -0.266
ENSG00000101040 E023 51.3007446 0.0029423502 1.170485e-02 3.283067e-02 20 47282102 47282217 116 - 1.763 1.659 -0.354
ENSG00000101040 E024 44.3849614 0.0005318833 3.254316e-04 1.482590e-03 20 47283571 47283648 78 - 1.724 1.566 -0.536
ENSG00000101040 E025 40.5053617 0.0192813591 2.208680e-02 5.585665e-02 20 47287229 47287284 56 - 1.685 1.530 -0.530
ENSG00000101040 E026 51.0730537 0.0023076057 1.379629e-04 6.946067e-04 20 47290187 47290274 88 - 1.786 1.613 -0.584
ENSG00000101040 E027 48.2984527 0.0004646894 9.225265e-05 4.855528e-04 20 47291796 47291888 93 - 1.759 1.592 -0.566
ENSG00000101040 E028 55.3180393 0.0004653407 1.705455e-05 1.074400e-04 20 47294666 47294779 114 - 1.820 1.647 -0.586
ENSG00000101040 E029 58.4855946 0.0003924777 7.216590e-08 7.531325e-07 20 47298729 47298872 144 - 1.863 1.644 -0.741
ENSG00000101040 E030 21.1571486 0.0071559754 1.440526e-07 1.419375e-06 20 47298873 47298947 75 - 1.500 1.063 -1.536
ENSG00000101040 E031 32.7590904 0.0006791368 4.195600e-03 1.369287e-02 20 47310056 47310102 47 - 1.587 1.444 -0.490
ENSG00000101040 E032 35.4970847 0.0005491761 1.541515e-03 5.770310e-03 20 47310103 47310156 54 - 1.626 1.472 -0.526
ENSG00000101040 E033 36.3776009 0.0005793660 4.540732e-05 2.584820e-04 20 47310157 47310204 48 - 1.657 1.450 -0.708
ENSG00000101040 E034 0.0000000       20 47318951 47319061 111 -      
ENSG00000101040 E035 35.2581087 0.0037618563 1.378443e-03 5.236559e-03 20 47347856 47347926 71 - 1.632 1.456 -0.601
ENSG00000101040 E036 0.1482932 0.0420607101 3.989573e-01   20 47348017 47348072 56 - 0.000 0.139 11.651
ENSG00000101040 E037 0.4804688 0.0211841627 6.987848e-01 7.986703e-01 20 47349861 47349988 128 - 0.194 0.139 -0.574
ENSG00000101040 E038 0.3634088 0.3312185508 2.188890e-01   20 47351710 47351877 168 - 0.000 0.245 12.664
ENSG00000101040 E039 1.0373134 0.0119759415 8.098849e-03 2.403055e-02 20 47355450 47355520 71 - 0.472 0.000 -13.885
ENSG00000101040 E040 0.0000000       20 47355521 47355657 137 -      
ENSG00000101040 E041 0.1472490 0.0433620506 5.935354e-01   20 47356380 47356414 35 - 0.107 0.000 -11.077
ENSG00000101040 E042 26.0176709 0.0019130807 1.645982e-03 6.108015e-03 20 47356657 47356889 233 - 1.511 1.322 -0.653
ENSG00000101040 E043 1.1521939 0.0377066430 4.048268e-01 5.485140e-01 20 47357621 47357653 33 - 0.381 0.245 -0.893
ENSG00000101040 E044 1.4811473 0.0787234556 5.421008e-01 6.729266e-01 20 47357654 47357788 135 - 0.429 0.330 -0.566
ENSG00000101040 E045 0.0000000       20 47357853 47357906 54 -