ENSG00000101004

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000278886 ENSG00000101004 HEK293_OSMI2_2hA HEK293_TMG_2hB NINL protein_coding protein_coding 4.185009 5.762521 3.030308 0.2746257 0.03156448 -0.924984 2.46049107 3.2506812 1.8113334 0.3012501 0.355264477 -0.8401783 0.60909583 0.56443333 0.59626667 0.03183333 9.098918e-01 7.446039e-06 FALSE TRUE
ENST00000422516 ENSG00000101004 HEK293_OSMI2_2hA HEK293_TMG_2hB NINL protein_coding protein_coding 4.185009 5.762521 3.030308 0.2746257 0.03156448 -0.924984 0.09709524 0.0000000 0.2520836 0.0000000 0.252083622 4.7119553 0.02877083 0.00000000 0.08430000 0.08430000 7.342657e-01 7.446039e-06 FALSE TRUE
ENST00000464285 ENSG00000101004 HEK293_OSMI2_2hA HEK293_TMG_2hB NINL protein_coding processed_transcript 4.185009 5.762521 3.030308 0.2746257 0.03156448 -0.924984 0.91752012 1.7128582 0.2703135 0.2209659 0.006517343 -2.6196910 0.17890000 0.29493333 0.08923333 -0.20570000 7.446039e-06 7.446039e-06 FALSE TRUE
ENST00000496509 ENSG00000101004 HEK293_OSMI2_2hA HEK293_TMG_2hB NINL protein_coding processed_transcript 4.185009 5.762521 3.030308 0.2746257 0.03156448 -0.924984 0.11401935 0.3239779 0.0000000 0.3239779 0.000000000 -5.0616808 0.02106667 0.05573333 0.00000000 -0.05573333 8.620435e-01 7.446039e-06 FALSE FALSE
MSTRG.20511.4 ENSG00000101004 HEK293_OSMI2_2hA HEK293_TMG_2hB NINL protein_coding   4.185009 5.762521 3.030308 0.2746257 0.03156448 -0.924984 0.50877435 0.3336885 0.6056387 0.0306444 0.127107385 0.8409825 0.14242500 0.05803333 0.20030000 0.14226667 4.565166e-03 7.446039e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000101004 E001 8.8168100 0.0408288925 1.528041e-03 5.727683e-03 20 25452697 25452825 129 - 0.557 1.081 2.083
ENSG00000101004 E002 6.6371756 0.0142893287 2.320097e-03 8.213928e-03 20 25452826 25452836 11 - 0.501 0.966 1.925
ENSG00000101004 E003 93.5546409 0.0009504985 1.009742e-08 1.243613e-07 20 25452837 25453273 437 - 1.766 2.003 0.799
ENSG00000101004 E004 71.0315822 0.0009979482 4.541310e-04 1.983030e-03 20 25453274 25453642 369 - 1.700 1.863 0.550
ENSG00000101004 E005 35.8750362 0.0006613147 1.661395e-02 4.408828e-02 20 25455673 25455786 114 - 1.425 1.575 0.513
ENSG00000101004 E006 37.2068069 0.0026739453 5.252406e-03 1.661855e-02 20 25458383 25458529 147 - 1.418 1.602 0.630
ENSG00000101004 E007 4.3113998 0.0044402800 2.026310e-01 3.295065e-01 20 25458530 25458976 447 - 0.557 0.751 0.830
ENSG00000101004 E008 39.4512984 0.0093780851 3.082216e-01 4.504903e-01 20 25461522 25461635 114 - 1.526 1.601 0.255
ENSG00000101004 E009 46.6401042 0.0134993536 8.229044e-01 8.883462e-01 20 25462383 25462541 159 - 1.639 1.653 0.048
ENSG00000101004 E010 0.2965864 0.2540583093 4.812551e-01   20 25462542 25462742 201 - 0.000 0.169 8.839
ENSG00000101004 E011 32.5449466 0.0055334867 7.234830e-01 8.172979e-01 20 25467389 25467458 70 - 1.509 1.482 -0.091
ENSG00000101004 E012 30.1582194 0.0007041106 6.198684e-01 7.371579e-01 20 25469991 25470095 105 - 1.479 1.445 -0.117
ENSG00000101004 E013 88.6832529 0.0003998628 4.303720e-01 5.730198e-01 20 25476043 25477089 1047 - 1.937 1.906 -0.106
ENSG00000101004 E014 30.2707058 0.0094331302 5.467611e-01 6.768798e-01 20 25478923 25479206 284 - 1.497 1.451 -0.160
ENSG00000101004 E015 23.7990998 0.0033242810 5.522820e-02 1.183804e-01 20 25480161 25480267 107 - 1.459 1.316 -0.495
ENSG00000101004 E016 0.6966286 0.5890595903 8.748378e-01 9.235743e-01 20 25481838 25481967 130 - 0.157 0.241 0.763
ENSG00000101004 E017 27.1211224 0.0018879736 5.148172e-02 1.117816e-01 20 25481968 25482100 133 - 1.497 1.361 -0.468
ENSG00000101004 E018 0.4772466 0.0217681645 9.409818e-01 9.668832e-01 20 25488983 25489243 261 - 0.157 0.172 0.165
ENSG00000101004 E019 19.9943994 0.0128505584 2.334135e-02 5.846199e-02 20 25489244 25489324 81 - 1.411 1.205 -0.719
ENSG00000101004 E020 25.5229428 0.0011228033 2.319713e-02 5.815768e-02 20 25489875 25489985 111 - 1.491 1.332 -0.549
ENSG00000101004 E021 3.9030716 0.0041986694 1.659203e-02 4.404061e-02 20 25489986 25490018 33 - 0.876 0.536 -1.419
ENSG00000101004 E022 30.6418905 0.0022168126 3.621573e-02 8.399395e-02 20 25491351 25491525 175 - 1.553 1.414 -0.480
ENSG00000101004 E023 25.1241944 0.0008197528 2.198754e-01 3.502626e-01 20 25496663 25496803 141 - 1.439 1.352 -0.304
ENSG00000101004 E024 24.7164988 0.0016754442 2.900752e-01 4.308553e-01 20 25498210 25498346 137 - 1.425 1.347 -0.271
ENSG00000101004 E025 30.5103289 0.0007144416 4.298138e-01 5.724697e-01 20 25500840 25501010 171 - 1.497 1.445 -0.180
ENSG00000101004 E026 25.2724973 0.0083591378 1.776539e-01 2.981855e-01 20 25503952 25504104 153 - 1.453 1.345 -0.374
ENSG00000101004 E027 27.6338909 0.0215808459 1.663790e-01 2.834813e-01 20 25504888 25505078 191 - 1.508 1.375 -0.458
ENSG00000101004 E028 5.3725619 0.0033619933 1.495240e-01 2.610170e-01 20 25509670 25509789 120 - 0.900 0.711 -0.746
ENSG00000101004 E029 18.9900350 0.0013710667 1.885834e-01 3.119532e-01 20 25510674 25510740 67 - 1.339 1.233 -0.373
ENSG00000101004 E030 26.4759385 0.0048598273 1.220844e-01 2.229081e-01 20 25512834 25513006 173 - 1.479 1.362 -0.402
ENSG00000101004 E031 19.1411096 0.0260942525 4.769908e-01 6.155912e-01 20 25517753 25517849 97 - 1.322 1.243 -0.278
ENSG00000101004 E032 23.4558453 0.0119275974 9.527127e-02 1.832818e-01 20 25526408 25526598 191 - 1.439 1.296 -0.497
ENSG00000101004 E033 9.1766119 0.0026738958 8.014512e-01 8.735043e-01 20 25585455 25585531 77 - 0.986 0.957 -0.109