ENSG00000100991

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000252015 ENSG00000100991 HEK293_OSMI2_2hA HEK293_TMG_2hB TRPC4AP protein_coding protein_coding 59.78131 82.58715 47.11508 6.087746 0.905163 -0.809597 43.16487 64.26905 30.91776 4.361122 0.2580515 -1.0554462 0.7116208 0.7792667 0.6566000 -0.1226667 0.0001622521 2.112635e-12 FALSE TRUE
ENST00000451813 ENSG00000100991 HEK293_OSMI2_2hA HEK293_TMG_2hB TRPC4AP protein_coding protein_coding 59.78131 82.58715 47.11508 6.087746 0.905163 -0.809597 12.21023 15.94713 11.47377 2.331550 0.9679970 -0.4746054 0.2053208 0.1913333 0.2429333 0.0516000 0.3323945998 2.112635e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100991 E001 156.641985 6.977394e-03 8.168036e-04 3.319696e-03 20 35002404 35002483 80 - 2.014 2.210 0.657
ENSG00000100991 E002 167.174851 7.415210e-03 7.687469e-03 2.299497e-02 20 35002484 35002485 2 - 2.070 2.230 0.536
ENSG00000100991 E003 352.105110 5.647520e-03 3.432780e-06 2.537278e-05 20 35002486 35002597 112 - 2.345 2.564 0.731
ENSG00000100991 E004 684.033118 3.760150e-03 3.522783e-10 5.666813e-09 20 35002598 35002747 150 - 2.626 2.852 0.755
ENSG00000100991 E005 1532.811082 2.531275e-03 6.700491e-10 1.027013e-08 20 35002748 35003283 536 - 3.022 3.189 0.557
ENSG00000100991 E006 789.656123 1.064312e-03 4.652969e-06 3.336074e-05 20 35003410 35003616 207 - 2.779 2.889 0.369
ENSG00000100991 E007 6.574072 3.852056e-03 8.657679e-02 1.699290e-01 20 35003873 35004038 166 - 0.966 0.768 -0.765
ENSG00000100991 E008 644.431796 1.036878e-04 1.046811e-04 5.436291e-04 20 35004458 35004570 113 - 2.716 2.795 0.263
ENSG00000100991 E009 544.529460 3.526846e-04 1.331712e-04 6.729496e-04 20 35005695 35005803 109 - 2.635 2.724 0.297
ENSG00000100991 E010 575.737798 2.640064e-04 6.918428e-03 2.101384e-02 20 35006435 35006549 115 - 2.677 2.742 0.218
ENSG00000100991 E011 376.519604 7.288586e-04 6.439839e-01 7.564018e-01 20 35006550 35006575 26 - 2.519 2.548 0.097
ENSG00000100991 E012 586.360811 2.267956e-03 6.337939e-01 7.484049e-01 20 35007550 35007640 91 - 2.727 2.732 0.016
ENSG00000100991 E013 35.627610 1.310701e-02 3.515707e-09 4.708995e-08 20 35007641 35007867 227 - 1.789 1.331 -1.566
ENSG00000100991 E014 22.525194 6.869508e-03 4.024080e-12 8.934138e-11 20 35008551 35008663 113 - 1.635 1.084 -1.921
ENSG00000100991 E015 625.873957 1.380260e-04 5.510923e-02 1.181875e-01 20 35008664 35008747 84 - 2.769 2.758 -0.038
ENSG00000100991 E016 667.844199 9.323219e-05 9.441406e-08 9.628835e-07 20 35010187 35010288 102 - 2.829 2.769 -0.200
ENSG00000100991 E017 514.411616 1.076844e-04 4.519910e-09 5.939400e-08 20 35013008 35013066 59 - 2.729 2.650 -0.264
ENSG00000100991 E018 605.634111 1.014760e-04 1.569386e-07 1.535007e-06 20 35016008 35016139 132 - 2.789 2.726 -0.208
ENSG00000100991 E019 485.035006 3.921123e-04 4.442117e-04 1.944467e-03 20 35021190 35021332 143 - 2.682 2.633 -0.165
ENSG00000100991 E020 186.315591 9.515544e-04 6.841809e-02 1.407523e-01 20 35021333 35021356 24 - 2.260 2.221 -0.132
ENSG00000100991 E021 555.579956 6.525990e-04 1.753088e-05 1.101367e-04 20 35035123 35035308 186 - 2.753 2.686 -0.224
ENSG00000100991 E022 692.424898 6.081863e-04 1.521592e-04 7.565310e-04 20 35044505 35044712 208 - 2.838 2.786 -0.172
ENSG00000100991 E023 466.727913 2.748555e-03 8.924552e-03 2.609110e-02 20 35049866 35049994 129 - 2.675 2.610 -0.217
ENSG00000100991 E024 335.672406 6.835856e-03 6.233375e-02 1.305793e-01 20 35054976 35055031 56 - 2.534 2.465 -0.229
ENSG00000100991 E025 363.297964 8.543352e-03 1.399593e-02 3.821854e-02 20 35057514 35057571 58 - 2.591 2.488 -0.343
ENSG00000100991 E026 340.047682 3.582961e-03 1.001208e-05 6.652960e-05 20 35069296 35069359 64 - 2.586 2.447 -0.463
ENSG00000100991 E027 269.051692 1.910742e-03 4.462998e-04 1.952659e-03 20 35069360 35069412 53 - 2.454 2.363 -0.306
ENSG00000100991 E028 341.791637 4.905215e-03 2.747438e-03 9.514385e-03 20 35078046 35078174 129 - 2.565 2.462 -0.345
ENSG00000100991 E029 194.463932 7.506796e-03 2.420080e-03 8.522508e-03 20 35092614 35092839 226 - 2.341 2.206 -0.453