ENSG00000100949

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000216840 ENSG00000100949 HEK293_OSMI2_2hA HEK293_TMG_2hB RABGGTA protein_coding protein_coding 30.93286 47.88873 16.91367 3.262408 0.1246903 -1.500945 15.006843 30.157331 7.279223 1.9187183 0.47298191 -2.0491501 0.44695000 0.63036667 0.4308000 -0.1995666667 1.548830e-04 1.506192e-06 FALSE TRUE
ENST00000399409 ENSG00000100949 HEK293_OSMI2_2hA HEK293_TMG_2hB RABGGTA protein_coding protein_coding 30.93286 47.88873 16.91367 3.262408 0.1246903 -1.500945 5.040759 7.064304 2.513855 0.7924722 0.45335445 -1.4869590 0.16197917 0.14783333 0.1482667 0.0004333333 1.000000e+00 1.506192e-06 FALSE TRUE
ENST00000560871 ENSG00000100949 HEK293_OSMI2_2hA HEK293_TMG_2hB RABGGTA protein_coding processed_transcript 30.93286 47.88873 16.91367 3.262408 0.1246903 -1.500945 1.518645 1.106537 1.141353 0.1166208 0.04670574 0.0442990 0.05550833 0.02366667 0.0675000 0.0438333333 1.371682e-04 1.506192e-06 FALSE FALSE
ENST00000560998 ENSG00000100949 HEK293_OSMI2_2hA HEK293_TMG_2hB RABGGTA protein_coding retained_intron 30.93286 47.88873 16.91367 3.262408 0.1246903 -1.500945 1.641367 1.262346 1.074903 0.6338788 0.58008927 -0.2299249 0.06311250 0.02686667 0.0632000 0.0363333333 8.986212e-01 1.506192e-06 TRUE TRUE
ENST00000561055 ENSG00000100949 HEK293_OSMI2_2hA HEK293_TMG_2hB RABGGTA protein_coding retained_intron 30.93286 47.88873 16.91367 3.262408 0.1246903 -1.500945 1.598838 0.973095 1.144897 0.1368565 0.07260540 0.2323613 0.05926250 0.02033333 0.0677000 0.0473666667 1.506192e-06 1.506192e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100949 E001 2.201532 0.0527811558 6.296434e-01 7.449759e-01 14 24265538 24265541 4 - 0.355 0.453 0.541
ENSG00000100949 E002 8.164125 0.0021167589 3.085674e-01 4.508533e-01 14 24265542 24265551 10 - 0.734 0.878 0.567
ENSG00000100949 E003 12.744111 0.0014274398 3.411978e-01 4.851095e-01 14 24265552 24265555 4 - 0.933 1.044 0.411
ENSG00000100949 E004 13.295554 0.0013720406 2.622712e-01 4.000458e-01 14 24265556 24265556 1 - 0.933 1.063 0.481
ENSG00000100949 E005 24.270253 0.0009008954 1.249139e-01 2.270026e-01 14 24265557 24265567 11 - 1.173 1.311 0.487
ENSG00000100949 E006 24.781955 0.0007995023 9.720096e-02 1.862037e-01 14 24265568 24265569 2 - 1.173 1.322 0.524
ENSG00000100949 E007 186.031281 0.0030285246 1.710596e-02 4.517625e-02 14 24265570 24265755 186 - 2.073 2.175 0.339
ENSG00000100949 E008 128.627011 0.0006835420 3.555573e-03 1.188476e-02 14 24265756 24265763 8 - 1.896 2.017 0.406
ENSG00000100949 E009 215.141039 0.0014399851 5.738757e-04 2.436103e-03 14 24266430 24266517 88 - 2.115 2.239 0.413
ENSG00000100949 E010 10.623221 0.0017177986 2.162202e-07 2.058923e-06 14 24266518 24266604 87 - 1.339 0.804 -1.956
ENSG00000100949 E011 9.025131 0.0019526020 3.648811e-08 4.039600e-07 14 24266605 24266664 60 - 1.313 0.715 -2.222
ENSG00000100949 E012 6.672108 0.0031794847 2.086538e-08 2.424042e-07 14 24266665 24266683 19 - 1.241 0.566 -2.613
ENSG00000100949 E013 9.706433 0.0018134232 1.635605e-08 1.938203e-07 14 24266684 24266775 92 - 1.339 0.743 -2.202
ENSG00000100949 E014 130.158677 0.0028024149 1.699297e-02 4.491905e-02 14 24266776 24266785 10 - 1.910 2.022 0.377
ENSG00000100949 E015 170.714168 0.0044057236 7.838400e-03 2.337675e-02 14 24266786 24266816 31 - 2.014 2.141 0.424
ENSG00000100949 E016 189.578470 0.0046429858 9.706777e-03 2.803874e-02 14 24266817 24266889 73 - 2.064 2.185 0.405
ENSG00000100949 E017 231.167568 0.0003244262 4.928988e-02 1.079068e-01 14 24267660 24267776 117 - 2.203 2.259 0.187
ENSG00000100949 E018 1.847763 0.0334459865 5.318057e-01 6.641988e-01 14 24267866 24267869 4 - 0.462 0.339 -0.679
ENSG00000100949 E019 177.469268 0.0002647287 1.581127e-01 2.725963e-01 14 24267870 24267903 34 - 2.096 2.140 0.149
ENSG00000100949 E020 188.966903 0.0002075173 3.163738e-02 7.514553e-02 14 24267904 24267958 55 - 2.105 2.172 0.226
ENSG00000100949 E021 10.635810 0.0048372632 9.011733e-02 1.753107e-01 14 24267959 24268109 151 - 1.114 0.915 -0.733
ENSG00000100949 E022 195.506276 0.0002192125 1.578586e-01 2.722698e-01 14 24268110 24268198 89 - 2.140 2.182 0.140
ENSG00000100949 E023 18.894639 0.0218682765 9.738104e-03 2.811850e-02 14 24268199 24268368 170 - 1.408 1.126 -0.991
ENSG00000100949 E024 190.509293 0.0003235019 9.702021e-01 9.853479e-01 14 24268369 24268420 52 - 2.165 2.162 -0.009
ENSG00000100949 E025 212.699933 0.0003823309 7.891409e-01 8.650140e-01 14 24268514 24268619 106 - 2.206 2.211 0.015
ENSG00000100949 E026 13.994277 0.0051480917 3.562140e-07 3.244695e-06 14 24268620 24268724 105 - 1.429 0.939 -1.749
ENSG00000100949 E027 200.376277 0.0002331632 2.737114e-03 9.484178e-03 14 24268725 24268826 102 - 2.105 2.200 0.318
ENSG00000100949 E028 6.646279 0.0418156698 7.037710e-03 2.132310e-02 14 24268827 24268910 84 - 1.070 0.663 -1.578
ENSG00000100949 E029 179.671879 0.0002127276 8.009476e-02 1.597001e-01 14 24268911 24268993 83 - 2.094 2.149 0.185
ENSG00000100949 E030 188.958917 0.0003972873 3.951287e-01 5.389646e-01 14 24269080 24269163 84 - 2.144 2.168 0.082
ENSG00000100949 E031 1.760909 0.1142999974 3.667464e-02 8.485674e-02 14 24269270 24269287 18 - 0.680 0.264 -2.176
ENSG00000100949 E032 2.459702 0.1538351995 1.096932e-02 3.108933e-02 14 24269288 24269345 58 - 0.825 0.306 -2.474
ENSG00000100949 E033 1.502917 0.0212570099 2.874690e-02 6.949725e-02 14 24269346 24269373 28 - 0.619 0.223 -2.230
ENSG00000100949 E034 1.727485 0.0838711258 1.256572e-03 4.831913e-03 14 24269374 24269401 28 - 0.782 0.177 -3.322
ENSG00000100949 E035 1.178118 0.0124977684 1.327416e-03 5.066895e-03 14 24269402 24269490 89 - 0.680 0.125 -3.499
ENSG00000100949 E036 177.061874 0.0002059797 3.555698e-01 4.999342e-01 14 24269491 24269551 61 - 2.111 2.138 0.090
ENSG00000100949 E037 212.991780 0.0011078023 7.069868e-01 8.050266e-01 14 24269552 24269628 77 - 2.208 2.217 0.031
ENSG00000100949 E038 143.047153 0.0010201578 9.535816e-01 9.749321e-01 14 24269629 24269659 31 - 2.050 2.044 -0.020
ENSG00000100949 E039 154.603238 0.0002648014 4.767010e-01 6.153082e-01 14 24269660 24269694 35 - 2.100 2.071 -0.098
ENSG00000100949 E040 113.157311 0.0008364025 5.816452e-01 7.061621e-01 14 24269953 24269954 2 - 1.966 1.939 -0.092
ENSG00000100949 E041 322.316993 0.0019137443 1.078014e-01 2.022866e-01 14 24269955 24270140 186 - 2.434 2.383 -0.173
ENSG00000100949 E042 109.813988 0.0075650223 1.471606e-01 2.578203e-01 14 24270334 24270348 15 - 1.992 1.910 -0.277
ENSG00000100949 E043 109.341576 0.0092010950 1.296665e-01 2.336846e-01 14 24270349 24270359 11 - 1.998 1.907 -0.305
ENSG00000100949 E044 239.912058 0.0015278405 2.520103e-02 6.228404e-02 14 24270360 24270458 99 - 2.323 2.248 -0.252
ENSG00000100949 E045 250.585546 0.0010658032 3.348850e-03 1.128878e-02 14 24270837 24270947 111 - 2.357 2.265 -0.308
ENSG00000100949 E046 15.466551 0.0169604793 2.060693e-01 3.337712e-01 14 24270948 24270998 51 - 1.225 1.077 -0.527
ENSG00000100949 E047 5.612681 0.0621651026 2.798698e-02 6.798631e-02 14 24270999 24271112 114 - 0.993 0.627 -1.449
ENSG00000100949 E048 171.384628 0.0021583522 8.592349e-04 3.470704e-03 14 24271113 24271169 57 - 2.221 2.091 -0.435
ENSG00000100949 E049 54.208838 0.0004974438 1.418736e-02 3.865157e-02 14 24271170 24271248 79 - 1.738 1.596 -0.481
ENSG00000100949 E050 56.495712 0.0124066814 1.038542e-01 1.963775e-01 14 24271249 24271486 238 - 1.743 1.617 -0.425
ENSG00000100949 E051 91.874248 0.0041980527 3.911062e-02 8.939146e-02 14 24271487 24271611 125 - 1.942 1.828 -0.381