ENSG00000100941

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000216832 ENSG00000100941 HEK293_OSMI2_2hA HEK293_TMG_2hB PNN protein_coding protein_coding 121.7923 63.05094 164.4663 8.602685 2.327069 1.383061 39.05031 24.43323 56.21436 0.7529642 0.9644866 1.201760 0.3309083 0.3989333 0.3418000 -0.05713333 0.59564086 0.02289115 FALSE TRUE
ENST00000553331 ENSG00000100941 HEK293_OSMI2_2hA HEK293_TMG_2hB PNN protein_coding protein_coding 121.7923 63.05094 164.4663 8.602685 2.327069 1.383061 31.73618 10.61018 48.68161 3.0127579 2.0111335 2.196864 0.2391833 0.1616000 0.2961667 0.13456667 0.02414618 0.02289115 FALSE TRUE
ENST00000554902 ENSG00000100941 HEK293_OSMI2_2hA HEK293_TMG_2hB PNN protein_coding retained_intron 121.7923 63.05094 164.4663 8.602685 2.327069 1.383061 49.05830 27.49557 57.24401 5.1056710 2.3291457 1.057653 0.4149417 0.4305333 0.3479667 -0.08256667 0.06691747 0.02289115 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100941 E001 3.9868208 0.0041876554 9.126495e-01 9.486429e-01 14 39174441 39175168 728 + 0.654 0.708 0.229
ENSG00000100941 E002 3.0269404 0.0055185560 5.908234e-01 7.136494e-01 14 39175169 39175182 14 + 0.541 0.662 0.539
ENSG00000100941 E003 32.6135773 0.0206183898 9.063635e-02 1.761323e-01 14 39175183 39175229 47 + 1.526 1.417 -0.374
ENSG00000100941 E004 78.8532161 0.0003387448 2.540569e-03 8.884836e-03 14 39175230 39175253 24 + 1.896 1.811 -0.287
ENSG00000100941 E005 241.7263763 0.0032306101 2.171289e-04 1.037229e-03 14 39175254 39175281 28 + 2.380 2.295 -0.285
ENSG00000100941 E006 495.4678658 0.0018829391 1.127769e-04 5.806562e-04 14 39175282 39175392 111 + 2.681 2.630 -0.170
ENSG00000100941 E007 494.8565091 0.0025577943 5.944404e-05 3.286972e-04 14 39176078 39176149 72 + 2.685 2.620 -0.219
ENSG00000100941 E008 2.8871564 0.0053851034 1.324058e-01 2.374288e-01 14 39176150 39176526 377 + 0.633 0.405 -1.099
ENSG00000100941 E009 489.3850604 0.0042049446 1.704413e-03 6.296724e-03 14 39176527 39176595 69 + 2.680 2.621 -0.199
ENSG00000100941 E010 495.6080028 0.0018654975 3.390385e-04 1.536599e-03 14 39177412 39177484 73 + 2.682 2.636 -0.152
ENSG00000100941 E011 1.8112481 0.0079829561 2.623679e-01 4.001546e-01 14 39177485 39177592 108 + 0.486 0.307 -1.006
ENSG00000100941 E012 287.8874815 0.0001658810 2.438872e-06 1.861851e-05 14 39177593 39177596 4 + 2.450 2.389 -0.204
ENSG00000100941 E013 515.6151164 0.0001339020 4.716633e-08 5.114487e-07 14 39177597 39177687 91 + 2.697 2.650 -0.155
ENSG00000100941 E014 1.2629112 0.0110807252 2.254154e-01 3.569129e-01 14 39177688 39177708 21 + 0.388 0.180 -1.490
ENSG00000100941 E015 497.2514625 0.0002994458 2.091922e-08 2.429402e-07 14 39177841 39177916 76 + 2.684 2.627 -0.189
ENSG00000100941 E016 0.8168978 0.0138776680 5.873756e-01 7.106689e-01 14 39179002 39179089 88 + 0.261 0.180 -0.682
ENSG00000100941 E017 1.4425393 0.0094856578 5.629826e-01 6.905271e-01 14 39179090 39179090 1 + 0.388 0.307 -0.490
ENSG00000100941 E018 575.3548827 0.0042907097 2.463140e-01 3.816333e-01 14 39179091 39179246 156 + 2.726 2.742 0.053
ENSG00000100941 E019 537.4506757 0.0037042477 9.668216e-01 9.832097e-01 14 39179324 39179462 139 + 2.683 2.736 0.175
ENSG00000100941 E020 699.8100874 0.0014774103 7.151509e-03 2.161678e-02 14 39180503 39180637 135 + 2.818 2.809 -0.029
ENSG00000100941 E021 534.5208182 0.0001467343 1.875124e-01 3.106029e-01 14 39180638 39180676 39 + 2.688 2.715 0.088
ENSG00000100941 E022 3952.4620015 0.0012020421 3.811393e-12 8.498787e-11 14 39180677 39182308 1632 + 3.519 3.656 0.454
ENSG00000100941 E023 586.8963905 0.0222209564 8.112672e-03 2.406893e-02 14 39182309 39183312 1004 + 2.644 2.892 0.825