ENSG00000100934

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307712 ENSG00000100934 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC23A protein_coding protein_coding 29.71404 8.411604 51.94713 2.530335 0.3266125 2.625155 20.254553 8.25529 36.65464 2.505787 1.3720648 2.149252 0.8016667 0.9797 0.7057000 -0.2740000 1.586862e-19 4.10344e-41 FALSE TRUE
ENST00000545328 ENSG00000100934 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC23A protein_coding protein_coding 29.71404 8.411604 51.94713 2.530335 0.3266125 2.625155 7.617936 0.00000 13.64279 0.000000 0.5212573 10.414980 0.1417750 0.0000 0.2625333 0.2625333 4.103440e-41 4.10344e-41 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100934 E001 548.9180416 0.0082983640 3.192971e-23 2.902586e-21 14 39031919 39032940 1022 - 2.483 2.978 1.648
ENSG00000100934 E002 186.3386544 0.0002374720 3.293075e-25 3.663318e-23 14 39032941 39033203 263 - 2.067 2.433 1.225
ENSG00000100934 E003 175.4852025 0.0008762950 3.487609e-07 3.183258e-06 14 39033204 39033328 125 - 2.076 2.309 0.780
ENSG00000100934 E004 176.8262741 0.0002108837 1.549265e-01 2.683167e-01 14 39039031 39039096 66 - 2.106 2.212 0.354
ENSG00000100934 E005 4.0759983 0.0124466969 5.142371e-01 6.489779e-01 14 39039097 39040731 1635 - 0.619 0.533 -0.386
ENSG00000100934 E006 269.9166044 0.0001665342 1.154229e-01 2.134590e-01 14 39040732 39040887 156 - 2.290 2.392 0.338
ENSG00000100934 E007 1.1115096 0.0873564063 1.000000e+00 1.000000e+00 14 39040888 39041433 546 - 0.253 0.258 0.039
ENSG00000100934 E008 234.2070255 0.0001937612 8.889751e-01 9.329886e-01 14 39042786 39042872 87 - 2.235 2.297 0.206
ENSG00000100934 E009 283.2310591 0.0009072217 7.607487e-01 8.447495e-01 14 39045163 39045324 162 - 2.317 2.380 0.213
ENSG00000100934 E010 167.2266791 0.0027003144 3.898565e-01 5.339081e-01 14 39048652 39048729 78 - 2.085 2.173 0.294
ENSG00000100934 E011 225.4196298 0.0002131055 4.408255e-01 5.824818e-01 14 39055143 39055296 154 - 2.224 2.256 0.109
ENSG00000100934 E012 204.6645585 0.0001886421 5.400005e-02 1.162649e-01 14 39061765 39061871 107 - 2.189 2.183 -0.022
ENSG00000100934 E013 178.2412518 0.0002466287 4.352443e-01 5.774858e-01 14 39063324 39063413 90 - 2.124 2.154 0.100
ENSG00000100934 E014 0.7374030 0.0154844416 8.132984e-01 8.816085e-01 14 39064549 39064912 364 - 0.184 0.256 0.614
ENSG00000100934 E015 187.6421219 0.0009522093 2.093196e-02 5.344623e-02 14 39064913 39064993 81 - 2.156 2.123 -0.109
ENSG00000100934 E016 246.4098043 0.0001905465 6.243239e-07 5.418559e-06 14 39067173 39067296 124 - 2.282 2.178 -0.346
ENSG00000100934 E017 249.5292871 0.0002487861 8.651000e-07 7.284027e-06 14 39074415 39074530 116 - 2.287 2.185 -0.341
ENSG00000100934 E018 286.4166944 0.0002058935 6.924053e-06 4.774134e-05 14 39075935 39076093 159 - 2.344 2.268 -0.253
ENSG00000100934 E019 258.9903708 0.0002035264 4.839879e-11 9.013079e-10 14 39085762 39085906 145 - 2.310 2.154 -0.521
ENSG00000100934 E020 177.0181036 0.0007508596 1.424683e-07 1.405300e-06 14 39086929 39087008 80 - 2.146 1.986 -0.539
ENSG00000100934 E021 0.5985731 0.0204956178 6.182696e-01 7.359728e-01 14 39087524 39088723 1200 - 0.144 0.256 1.028
ENSG00000100934 E022 0.7512344 0.3117700865 6.714650e-01 7.776753e-01 14 39091370 39091476 107 - 0.220 0.000 -9.524
ENSG00000100934 E023 188.3381955 0.0002530630 6.507925e-09 8.311293e-08 14 39091477 39091572 96 - 2.173 2.007 -0.555
ENSG00000100934 E024 185.6767228 0.0041407587 1.403736e-05 9.011032e-05 14 39091573 39091657 85 - 2.168 1.995 -0.581
ENSG00000100934 E025 155.8950495 0.0007111282 5.897530e-06 4.131149e-05 14 39091658 39091713 56 - 2.090 1.952 -0.462
ENSG00000100934 E026 169.0637108 0.0002516018 8.779429e-05 4.646950e-04 14 39092541 39092627 87 - 2.119 2.024 -0.319
ENSG00000100934 E027 0.0000000       14 39092761 39093184 424 -      
ENSG00000100934 E028 0.0000000       14 39093185 39093186 2 -      
ENSG00000100934 E029 159.0739495 0.0002229355 4.739356e-05 2.685621e-04 14 39093187 39093244 58 - 2.095 1.989 -0.354
ENSG00000100934 E030 0.0000000       14 39094898 39094977 80 -      
ENSG00000100934 E031 0.0000000       14 39094978 39095014 37 -      
ENSG00000100934 E032 0.0000000       14 39095015 39095017 3 -      
ENSG00000100934 E033 213.8218917 0.0002616294 4.961136e-06 3.533222e-05 14 39095898 39095998 101 - 2.222 2.121 -0.338
ENSG00000100934 E034 201.6990458 0.0009580390 5.091478e-07 4.498021e-06 14 39095999 39096139 141 - 2.201 2.061 -0.467
ENSG00000100934 E035 118.5776998 0.0020241027 4.369736e-05 2.497009e-04 14 39103032 39103123 92 - 1.973 1.810 -0.549
ENSG00000100934 E036 70.7095618 0.0059709231 2.702197e-03 9.381036e-03 14 39103124 39103197 74 - 1.753 1.580 -0.588
ENSG00000100934 E037 32.1562925 0.0036286677 2.824287e-04 1.308229e-03 14 39103198 39103228 31 - 1.434 1.117 -1.115
ENSG00000100934 E038 2.2228062 0.0065229499 2.963417e-01 4.375416e-01 14 39103229 39103243 15 - 0.453 0.257 -1.193
ENSG00000100934 E039 0.1451727 0.0458029326 1.000000e+00   14 39103593 39103663 71 - 0.054 0.000 -7.189
ENSG00000100934 E040 0.0000000       14 39103664 39103829 166 -      
ENSG00000100934 E041 0.0000000       14 39109473 39109646 174 -