ENSG00000100911

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000216802 ENSG00000100911 HEK293_OSMI2_2hA HEK293_TMG_2hB PSME2 protein_coding protein_coding 66.8429 86.33687 55.57431 12.02272 0.385263 -0.635466 54.11075 78.45492 43.16801 12.23417 1.526957 -0.8617512 0.7970458 0.9044333 0.7767667 -0.1276667 0.004469496 8.885498e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100911 E001 0.3289534 0.0269676661 6.235225e-01   14 24143362 24143364 3 - 0.164 0.090 -0.989
ENSG00000100911 E002 3.8996328 0.1133502057 5.532728e-01 6.824439e-01 14 24143365 24143365 1 - 0.746 0.638 -0.450
ENSG00000100911 E003 6.8136646 0.0049421984 2.618853e-01 3.996181e-01 14 24143366 24143366 1 - 0.966 0.830 -0.520
ENSG00000100911 E004 27.2377099 0.0027763378 3.678412e-01 5.122231e-01 14 24143367 24143381 15 - 1.379 1.445 0.230
ENSG00000100911 E005 108.4470346 0.0002741599 3.748046e-02 8.636681e-02 14 24143382 24143404 23 - 2.060 1.984 -0.252
ENSG00000100911 E006 112.4875958 0.0002700690 7.114520e-02 1.452428e-01 14 24143405 24143406 2 - 2.068 2.004 -0.216
ENSG00000100911 E007 237.7635710 0.0005311306 7.787843e-03 2.324610e-02 14 24143407 24143488 82 - 2.297 2.364 0.224
ENSG00000100911 E008 158.7694016 0.0023796808 1.556932e-04 7.724481e-04 14 24143489 24143489 1 - 2.067 2.205 0.465
ENSG00000100911 E009 3.8919228 0.0396629972 4.281464e-02 9.620458e-02 14 24143490 24143584 95 - 0.871 0.546 -1.355
ENSG00000100911 E010 173.0030589 0.0033619710 5.391788e-03 1.699202e-02 14 24143585 24143593 9 - 2.130 2.233 0.345
ENSG00000100911 E011 429.4166689 0.0001447168 1.315435e-01 2.362896e-01 14 24143594 24143671 78 - 2.585 2.612 0.088
ENSG00000100911 E012 14.2967672 0.0256230843 2.863834e-03 9.864098e-03 14 24143672 24143974 303 - 1.362 1.010 -1.253
ENSG00000100911 E013 499.4670489 0.0001988397 4.115626e-01 5.551155e-01 14 24143975 24144029 55 - 2.661 2.673 0.043
ENSG00000100911 E014 6.8455738 0.0054527226 1.151508e-05 7.544776e-05 14 24144034 24144191 158 - 1.169 0.649 -1.994
ENSG00000100911 E015 355.2962172 0.0007491657 9.671695e-01 9.834197e-01 14 24144192 24144202 11 - 2.522 2.521 -0.003
ENSG00000100911 E016 552.3233788 0.0001981096 9.482996e-01 9.715568e-01 14 24144203 24144259 57 - 2.715 2.712 -0.010
ENSG00000100911 E017 604.3450544 0.0006222834 6.614283e-02 1.369505e-01 14 24144400 24144468 69 - 2.728 2.758 0.101
ENSG00000100911 E018 38.4835149 0.0234974081 1.115251e-05 7.329273e-05 14 24144469 24144799 331 - 1.811 1.380 -1.473
ENSG00000100911 E019 35.4901300 0.0315834476 1.743664e-06 1.374207e-05 14 24144800 24145057 258 - 1.817 1.293 -1.793
ENSG00000100911 E020 479.3553329 0.0016705278 2.000184e-01 3.262775e-01 14 24145058 24145133 76 - 2.627 2.656 0.096
ENSG00000100911 E021 257.0962720 0.0019107076 1.423983e-01 2.513129e-01 14 24145134 24145155 22 - 2.348 2.392 0.147
ENSG00000100911 E022 47.2743414 0.0009102701 4.150782e-01 5.585025e-01 14 24145156 24145169 14 - 1.626 1.671 0.151
ENSG00000100911 E023 3.9704632 0.0751061849 1.025549e-03 4.046553e-03 14 24145170 24145184 15 - 0.988 0.380 -2.645
ENSG00000100911 E024 4.4884973 0.0354150594 1.486073e-05 9.494494e-05 14 24145185 24145226 42 - 1.063 0.378 -2.931
ENSG00000100911 E025 4.0757682 0.0277891187 5.609321e-05 3.121641e-04 14 24145227 24145242 16 - 1.008 0.378 -2.726
ENSG00000100911 E026 340.2364268 0.0002573862 1.678348e-01 2.853744e-01 14 24145243 24145273 31 - 2.524 2.494 -0.101
ENSG00000100911 E027 16.3033518 0.0314403505 6.735099e-01 7.791761e-01 14 24145274 24145378 105 - 1.243 1.188 -0.196
ENSG00000100911 E028 554.9472427 0.0001487545 4.201843e-01 5.634110e-01 14 24145379 24145465 87 - 2.706 2.717 0.037
ENSG00000100911 E029 16.4542759 0.0167609585 2.577116e-05 1.557491e-04 14 24145466 24145709 244 - 1.462 1.020 -1.563
ENSG00000100911 E030 359.3155558 0.0001528035 4.089094e-01 5.525203e-01 14 24145710 24145740 31 - 2.515 2.529 0.049
ENSG00000100911 E031 293.6420223 0.0007347556 3.978619e-01 5.416142e-01 14 24145741 24145752 12 - 2.424 2.440 0.052
ENSG00000100911 E032 285.7235387 0.0014569999 5.812905e-01 7.058489e-01 14 24145753 24145772 20 - 2.417 2.425 0.025
ENSG00000100911 E033 35.0590592 0.0666304371 1.985919e-03 7.182499e-03 14 24145773 24145857 85 - 1.769 1.343 -1.455
ENSG00000100911 E034 17.8153425 0.1580405073 6.044384e-03 1.872807e-02 14 24145858 24145896 39 - 1.532 1.003 -1.865
ENSG00000100911 E035 11.2754503 0.0025138900 1.555383e-11 3.138383e-10 14 24145897 24145911 15 - 1.403 0.731 -2.470
ENSG00000100911 E036 50.0509156 0.0029306111 3.828684e-14 1.155356e-12 14 24145912 24146207 296 - 1.922 1.500 -1.430
ENSG00000100911 E037 338.8213637 0.0005970673 6.885513e-01 7.906514e-01 14 24146208 24146240 33 - 2.495 2.500 0.015
ENSG00000100911 E038 12.0645411 0.0015836662 2.383592e-04 1.126405e-03 14 24146241 24146314 74 - 1.297 0.947 -1.260
ENSG00000100911 E039 343.0695807 0.0011865501 8.978804e-02 1.748083e-01 14 24146534 24146809 276 - 2.476 2.511 0.117
ENSG00000100911 E040 65.2272210 0.0316986857 6.022501e-01 7.232384e-01 14 24146810 24147221 412 - 1.829 1.757 -0.242
ENSG00000100911 E041 9.4983888 0.1361743842 6.655826e-01 7.732328e-01 14 24147222 24147258 37 - 0.920 0.998 0.291
ENSG00000100911 E042 0.9170165 0.0927162301 8.220978e-01 8.878124e-01 14 24147523 24147570 48 - 0.283 0.231 -0.384