ENSG00000100908

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000216799 ENSG00000100908 HEK293_OSMI2_2hA HEK293_TMG_2hB EMC9 protein_coding protein_coding 53.04858 92.51638 34.15785 3.709586 1.639582 -1.437225 20.668136 41.294950 10.856544 1.76920505 0.7825308 -1.9264215 0.36732500 0.44623333 0.32026667 -0.125966667 3.349690e-02 1.917154e-15 FALSE TRUE
ENST00000419198 ENSG00000100908 HEK293_OSMI2_2hA HEK293_TMG_2hB EMC9 protein_coding protein_coding 53.04858 92.51638 34.15785 3.709586 1.639582 -1.437225 16.809400 30.348253 11.172378 2.58408450 1.7520645 -1.4408618 0.29851667 0.32730000 0.32383333 -0.003466667 9.960290e-01 1.917154e-15 FALSE TRUE
ENST00000558045 ENSG00000100908 HEK293_OSMI2_2hA HEK293_TMG_2hB EMC9 protein_coding retained_intron 53.04858 92.51638 34.15785 3.709586 1.639582 -1.437225 2.331439 2.597247 1.759502 0.45363294 0.2088454 -0.5591835 0.05306250 0.02783333 0.05146667 0.023633333 5.729715e-02 1.917154e-15   FALSE
ENST00000559101 ENSG00000100908 HEK293_OSMI2_2hA HEK293_TMG_2hB EMC9 protein_coding retained_intron 53.04858 92.51638 34.15785 3.709586 1.639582 -1.437225 2.775676 2.127396 3.122306 0.06399581 0.3174877 0.5513707 0.06969583 0.02310000 0.09120000 0.068100000 1.917154e-15 1.917154e-15   FALSE
MSTRG.9244.3 ENSG00000100908 HEK293_OSMI2_2hA HEK293_TMG_2hB EMC9 protein_coding   53.04858 92.51638 34.15785 3.709586 1.639582 -1.437225 6.384285 8.409041 3.082195 0.60910477 1.5542923 -1.4450246 0.13423750 0.09116667 0.09303333 0.001866667 8.960207e-01 1.917154e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100908 E001 4.311503 0.1466291701 2.380208e-01 3.718465e-01 14 24138959 24138964 6 - 0.841 0.584 -1.065
ENSG00000100908 E002 58.679375 0.0183817781 2.929244e-01 4.339543e-01 14 24138965 24138980 16 - 1.611 1.699 0.299
ENSG00000100908 E003 378.582857 0.0039613685 4.567078e-03 1.472939e-02 14 24138981 24139129 149 - 2.399 2.500 0.337
ENSG00000100908 E004 360.803190 0.0006062205 6.924554e-04 2.871454e-03 14 24139130 24139169 40 - 2.394 2.477 0.277
ENSG00000100908 E005 308.552449 0.0002559000 6.696148e-04 2.787137e-03 14 24139170 24139196 27 - 2.325 2.410 0.281
ENSG00000100908 E006 13.432883 0.0014225082 2.808122e-02 6.817503e-02 14 24139197 24139359 163 - 1.232 1.011 -0.794
ENSG00000100908 E007 296.319604 0.0002686371 1.981680e-03 7.169630e-03 14 24139360 24139388 29 - 2.313 2.391 0.261
ENSG00000100908 E008 418.290664 0.0002014719 5.274809e-03 1.667996e-02 14 24139389 24139454 66 - 2.476 2.534 0.192
ENSG00000100908 E009 7.744144 0.0262036198 7.538155e-02 1.521306e-01 14 24139455 24139523 69 - 1.045 0.791 -0.964
ENSG00000100908 E010 410.520861 0.0009150323 4.716026e-01 6.106913e-01 14 24139545 24139614 70 - 2.531 2.510 -0.067
ENSG00000100908 E011 145.688589 0.0032336987 1.287023e-05 8.334389e-05 14 24139615 24139789 175 - 2.211 2.029 -0.610
ENSG00000100908 E012 18.682125 0.0182293865 5.313371e-04 2.276814e-03 14 24139790 24139816 27 - 1.462 1.105 -1.253
ENSG00000100908 E013 17.894881 0.0010291696 1.509579e-09 2.164751e-08 14 24139817 24140008 192 - 1.528 1.033 -1.740
ENSG00000100908 E014 467.345261 0.0032089816 4.657175e-01 6.053599e-01 14 24140889 24140965 77 - 2.592 2.567 -0.085
ENSG00000100908 E015 609.480340 0.0009131879 1.294837e-01 2.334408e-01 14 24141107 24141316 210 - 2.712 2.680 -0.109
ENSG00000100908 E016 104.519366 0.0002885334 1.135513e-02 3.201517e-02 14 24141317 24141347 31 - 2.006 1.903 -0.346
ENSG00000100908 E017 207.386067 0.0002881819 3.766085e-02 8.669663e-02 14 24141348 24141437 90 - 2.268 2.205 -0.211
ENSG00000100908 E018 276.787744 0.0024759281 3.451919e-02 8.074924e-02 14 24141438 24141645 208 - 2.400 2.328 -0.242