ENSG00000100865

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000216756 ENSG00000100865 HEK293_OSMI2_2hA HEK293_TMG_2hB CINP protein_coding protein_coding 46.583 63.32519 40.70249 5.405128 0.5186268 -0.6375358 38.792227 56.185675 31.200154 4.8598995 0.55414920 -0.8484436 0.8239250 0.88706667 0.76663333 -0.12043333 6.608872e-07 2.136088e-15 FALSE TRUE
ENST00000559514 ENSG00000100865 HEK293_OSMI2_2hA HEK293_TMG_2hB CINP protein_coding nonsense_mediated_decay 46.583 63.32519 40.70249 5.405128 0.5186268 -0.6375358 2.351407 3.008173 2.777418 0.2819225 0.07630879 -0.1147462 0.0514375 0.04746667 0.06823333 0.02076667 2.483658e-02 2.136088e-15 TRUE TRUE
ENST00000560326 ENSG00000100865 HEK293_OSMI2_2hA HEK293_TMG_2hB CINP protein_coding processed_transcript 46.583 63.32519 40.70249 5.405128 0.5186268 -0.6375358 3.013844 2.716643 3.714714 0.3995544 0.37180362 0.4500038 0.0689000 0.04263333 0.09133333 0.04870000 9.048667e-04 2.136088e-15   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100865 E001 92.6500605 0.0003421013 3.375327e-02 7.925997e-02 14 102341102 102342505 1404 - 2.002 1.919 -0.278
ENSG00000100865 E002 12.4525600 0.0243264878 1.515069e-01 2.637203e-01 14 102342506 102342578 73 - 1.207 1.026 -0.651
ENSG00000100865 E003 8.6742766 0.0300295826 1.334590e-01 2.389465e-01 14 102342579 102342618 40 - 1.083 0.874 -0.776
ENSG00000100865 E004 9.5752226 0.0023522642 3.362615e-01 4.800873e-01 14 102342619 102342726 108 - 1.066 0.960 -0.393
ENSG00000100865 E005 98.1227934 0.0019893608 8.969349e-05 4.735699e-04 14 102342727 102343634 908 - 2.074 1.906 -0.565
ENSG00000100865 E006 32.0289074 0.0012841016 7.967903e-04 3.247903e-03 14 102343635 102343820 186 - 1.631 1.419 -0.724
ENSG00000100865 E007 75.3850679 0.0003999228 5.855921e-17 2.588396e-15 14 102343821 102344389 569 - 2.059 1.718 -1.148
ENSG00000100865 E008 40.0262324 0.0030073974 2.747136e-04 1.276863e-03 14 102347037 102347455 419 - 1.724 1.499 -0.766
ENSG00000100865 E009 27.9711821 0.0047762698 1.988294e-04 9.588178e-04 14 102348009 102348278 270 - 1.603 1.331 -0.934
ENSG00000100865 E010 22.0399157 0.0009396995 1.239474e-07 1.236908e-06 14 102348279 102348281 3 - 1.562 1.178 -1.335
ENSG00000100865 E011 262.8575825 0.0018212434 1.904749e-01 3.143531e-01 14 102348282 102348484 203 - 2.368 2.404 0.118
ENSG00000100865 E012 181.8008404 0.0004239910 6.199488e-04 2.606583e-03 14 102348485 102348510 26 - 2.167 2.264 0.322
ENSG00000100865 E013 542.3107479 0.0001335866 2.156252e-09 3.002981e-08 14 102348511 102348759 249 - 2.642 2.733 0.301
ENSG00000100865 E014 360.0960483 0.0001679308 1.120936e-03 4.373737e-03 14 102349919 102350005 87 - 2.487 2.548 0.201
ENSG00000100865 E015 289.8933162 0.0001585850 2.605252e-04 1.218840e-03 14 102350006 102350048 43 - 2.381 2.458 0.256
ENSG00000100865 E016 1.4392153 0.0095208152 5.675812e-01 6.943603e-01 14 102352419 102352555 137 - 0.443 0.341 -0.574
ENSG00000100865 E017 0.7782011 0.0158434247 2.641921e-01 4.021469e-01 14 102355538 102355767 230 - 0.368 0.169 -1.481
ENSG00000100865 E018 209.1561921 0.0001785170 1.293077e-01 2.332110e-01 14 102355768 102355771 4 - 2.270 2.305 0.119
ENSG00000100865 E019 446.7048582 0.0002494479 5.591115e-01 6.872607e-01 14 102355772 102355897 126 - 2.617 2.622 0.018
ENSG00000100865 E020 334.8956685 0.0027238656 1.804706e-02 4.723366e-02 14 102359419 102359587 169 - 2.548 2.465 -0.276
ENSG00000100865 E021 1.6887731 0.0081174738 7.323449e-01 8.238130e-01 14 102359588 102359595 8 - 0.368 0.427 0.328
ENSG00000100865 E022 0.8951594 0.1381523066 4.547250e-01 5.953276e-01 14 102362574 102362844 271 - 0.368 0.231 -0.929
ENSG00000100865 E023 140.3735521 0.0002964702 3.685510e-03 1.225444e-02 14 102362845 102362916 72 - 2.183 2.089 -0.312