ENSG00000100852

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000345122 ENSG00000100852 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP5 protein_coding protein_coding 7.841415 1.325983 14.40912 0.08917353 0.5837922 3.432009 2.09418601 0.34676877 3.32678983 0.17697290 0.77451080 3.225400 0.24283750 0.28020000 0.2274333333 -0.05276667 1.000000e+00 2.892301e-16 FALSE TRUE
ENST00000539826 ENSG00000100852 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP5 protein_coding protein_coding 7.841415 1.325983 14.40912 0.08917353 0.5837922 3.432009 1.66384612 0.05716073 3.00360854 0.05716073 0.41683571 5.487730 0.24816667 0.03900000 0.2092666667 0.17026667 6.367568e-02 2.892301e-16 FALSE TRUE
ENST00000556191 ENSG00000100852 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP5 protein_coding protein_coding 7.841415 1.325983 14.40912 0.08917353 0.5837922 3.432009 2.51261125 0.00000000 5.47165896 0.00000000 0.39528870 9.098469 0.16950417 0.00000000 0.3789666667 0.37896667 2.892301e-16 2.892301e-16 FALSE TRUE
ENST00000557643 ENSG00000100852 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP5 protein_coding nonsense_mediated_decay 7.841415 1.325983 14.40912 0.08917353 0.5837922 3.432009 0.04308560 0.05907990 0.01015720 0.05907990 0.01015720 -1.776971 0.02269583 0.05093333 0.0007666667 -0.05016667 3.705806e-01 2.892301e-16 FALSE TRUE
MSTRG.9335.13 ENSG00000100852 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP5 protein_coding   7.841415 1.325983 14.40912 0.08917353 0.5837922 3.432009 0.07660158 0.40188151 0.02579048 0.40188151 0.02579048 -3.524581 0.05488333 0.27416667 0.0017000000 -0.27246667 6.170187e-01 2.892301e-16 FALSE TRUE
MSTRG.9335.6 ENSG00000100852 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP5 protein_coding   7.841415 1.325983 14.40912 0.08917353 0.5837922 3.432009 0.24079190 0.34715999 0.10137975 0.18675848 0.02596488 -1.681083 0.10457917 0.27316667 0.0069333333 -0.26623333 8.299712e-02 2.892301e-16 FALSE TRUE
MSTRG.9335.7 ENSG00000100852 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP5 protein_coding   7.841415 1.325983 14.40912 0.08917353 0.5837922 3.432009 0.82231174 0.07483545 1.98327677 0.07483545 0.41831571 4.554331 0.08543750 0.05536667 0.1405333333 0.08516667 3.526582e-01 2.892301e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100852 E001 0.5181333 0.0202830077 2.082383e-01 3.363749e-01 14 32075042 32076113 1072 + 0.074 0.332 2.633
ENSG00000100852 E002 0.5997190 0.1403499910 1.000000e+00 1.000000e+00 14 32076114 32076217 104 + 0.137 0.000 -13.710
ENSG00000100852 E003 0.2924217 0.0273369290 1.000000e+00   14 32076218 32076457 240 + 0.074 0.000 -12.706
ENSG00000100852 E004 0.8878743 0.0131453660 7.682251e-01 8.502637e-01 14 32076458 32076657 200 + 0.192 0.000 -14.291
ENSG00000100852 E005 0.7341688 0.3264947836 1.000000e+00 1.000000e+00 14 32076967 32076984 18 + 0.165 0.000 -14.025
ENSG00000100852 E006 3.9932442 0.0040654110 4.320194e-02 9.692082e-02 14 32076985 32077053 69 + 0.544 0.000 -16.461
ENSG00000100852 E007 0.2214452 0.0372382146 2.865988e-02   14 32077074 32077257 184 + 0.000 0.332 18.697
ENSG00000100852 E008 0.5911862 0.0172671820 1.000000e+00 1.000000e+00 14 32077258 32077273 16 + 0.137 0.000 -13.706
ENSG00000100852 E009 4.3794419 0.0224321946 6.675643e-01 7.747684e-01 14 32077274 32077303 30 + 0.543 0.518 -0.120
ENSG00000100852 E010 4.8339882 0.0034723727 5.418303e-01 6.727451e-01 14 32077304 32077308 5 + 0.577 0.517 -0.276
ENSG00000100852 E011 17.4779407 0.0039724800 8.559513e-01 9.109506e-01 14 32077309 32077435 127 + 1.030 1.096 0.241
ENSG00000100852 E012 0.1472490 0.0438634592 5.871956e-01   14 32078231 32078296 66 + 0.038 0.000 -11.706
ENSG00000100852 E013 612.8058864 0.0511563095 1.526778e-07 1.496578e-06 14 32090502 32093977 3476 + 2.566 2.214 -1.172
ENSG00000100852 E014 38.5084057 0.0046885807 3.644441e-03 1.213940e-02 14 32093978 32094037 60 + 1.377 1.134 -0.856
ENSG00000100852 E015 113.2273511 0.0002979145 2.412696e-03 8.499980e-03 14 32094038 32094386 349 + 1.821 1.739 -0.276
ENSG00000100852 E016 1.3891695 0.4581103416 6.786039e-01 7.830324e-01 14 32116777 32116823 47 + 0.239 0.338 0.684
ENSG00000100852 E017 24.3363610 0.0010968594 2.774808e-01 4.170500e-01 14 32117140 32117142 3 + 1.172 1.134 -0.138
ENSG00000100852 E018 68.2757259 0.0004525942 6.635119e-02 1.373099e-01 14 32117143 32117287 145 + 1.602 1.562 -0.136
ENSG00000100852 E019 55.7245554 0.0004666448 2.567909e-01 3.937856e-01 14 32146263 32146340 78 + 1.514 1.519 0.020
ENSG00000100852 E020 71.4159243 0.0006478733 4.496245e-01 5.908181e-01 14 32149902 32150033 132 + 1.615 1.660 0.152
ENSG00000100852 E021 75.8633630 0.0003915246 5.325746e-01 6.649224e-01 14 32152423 32152528 106 + 1.629 1.766 0.465
ENSG00000100852 E022 1.1929934 0.2235925032 2.576929e-01 3.948588e-01 14 32154010 32154620 611 + 0.192 0.510 2.008
ENSG00000100852 E023 530.4407119 0.0575010995 1.780610e-06 1.400296e-05 14 32154621 32159728 5108 + 2.421 2.849 1.425