ENSG00000100823

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000216714 ENSG00000100823 HEK293_OSMI2_2hA HEK293_TMG_2hB APEX1 protein_coding protein_coding 236.1761 312.1349 204.5165 41.41418 2.599076 -0.6099286 171.03181 228.80994 138.85399 29.882079 0.9266764 -0.7205403 0.72145000 0.73343333 0.67923333 -0.0542 0.03281336 0.01532438 FALSE  
ENST00000555414 ENSG00000100823 HEK293_OSMI2_2hA HEK293_TMG_2hB APEX1 protein_coding protein_coding 236.1761 312.1349 204.5165 41.41418 2.599076 -0.6099286 19.34303 30.84886 15.84293 5.172304 1.7245335 -0.9609351 0.07967917 0.09786667 0.07726667 -0.0206 0.35082919 0.01532438 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100823 E001 9.29906 1.631802e-01 6.461903e-01 7.581662e-01 14 20455191 20455200 10 + 0.957 1.002 0.164
ENSG00000100823 E002 41.45142 5.453680e-04 7.195057e-02 1.465790e-01 14 20455201 20455214 14 + 1.661 1.577 -0.286
ENSG00000100823 E003 51.84296 1.347706e-03 5.447573e-01 6.751758e-01 14 20455215 20455218 4 + 1.714 1.697 -0.059
ENSG00000100823 E004 73.00720 3.216370e-03 1.984168e-01 3.242288e-01 14 20455219 20455225 7 + 1.882 1.828 -0.183
ENSG00000100823 E005 80.24609 2.151299e-03 2.245719e-01 3.559224e-01 14 20455226 20455226 1 + 1.917 1.874 -0.146
ENSG00000100823 E006 142.15464 3.354216e-04 4.109488e-08 4.510081e-07 14 20455227 20455238 12 + 2.231 2.077 -0.514
ENSG00000100823 E007 151.10265 2.620286e-04 1.627083e-09 2.319383e-08 14 20455239 20455239 1 + 2.263 2.100 -0.545
ENSG00000100823 E008 173.53688 2.753917e-04 2.141236e-07 2.040804e-06 14 20455240 20455240 1 + 2.303 2.174 -0.433
ENSG00000100823 E009 229.36303 1.829517e-04 1.144890e-03 4.453717e-03 14 20455241 20455244 4 + 2.385 2.322 -0.211
ENSG00000100823 E010 301.93825 1.787720e-04 9.661687e-03 2.793161e-02 14 20455245 20455246 2 + 2.489 2.450 -0.132
ENSG00000100823 E011 329.06449 1.513144e-04 3.740593e-05 2.171690e-04 14 20455247 20455247 1 + 2.545 2.476 -0.227
ENSG00000100823 E012 540.33528 1.163929e-04 5.726039e-02 1.219156e-01 14 20455248 20455256 9 + 2.724 2.709 -0.050
ENSG00000100823 E013 693.05421 1.060232e-04 1.715229e-01 2.901838e-01 14 20455257 20455264 8 + 2.825 2.821 -0.013
ENSG00000100823 E014 1146.54912 2.696631e-04 1.653304e-03 6.132422e-03 14 20455265 20455328 64 + 3.058 3.028 -0.097
ENSG00000100823 E015 878.03715 4.074067e-04 3.712676e-05 2.156804e-04 14 20455329 20455338 10 + 2.956 2.904 -0.174
ENSG00000100823 E016 1155.43731 3.292609e-04 7.705473e-07 6.559625e-06 14 20455339 20455389 51 + 3.078 3.022 -0.185
ENSG00000100823 E017 803.18632 3.108366e-04 1.693992e-06 1.338903e-05 14 20455390 20455394 5 + 2.923 2.863 -0.200
ENSG00000100823 E018 65.30744 1.789684e-03 6.261282e-16 2.429206e-14 14 20455395 20455401 7 + 2.007 1.636 -1.252
ENSG00000100823 E019 62.69868 8.655519e-03 4.562635e-11 8.524434e-10 14 20455402 20455428 27 + 2.007 1.594 -1.395
ENSG00000100823 E020 147.50187 1.253747e-03 2.537162e-21 1.887153e-19 14 20455429 20455577 149 + 2.327 2.021 -1.025
ENSG00000100823 E021 1724.81780 3.355754e-04 2.177275e-03 7.771318e-03 14 20455578 20455672 95 + 3.232 3.205 -0.090
ENSG00000100823 E022 1212.75707 1.578644e-04 1.203891e-01 2.205266e-01 14 20455673 20455703 31 + 3.066 3.062 -0.016
ENSG00000100823 E023 32.04220 6.623041e-04 2.129784e-18 1.126413e-16 14 20455704 20455734 31 + 1.771 1.250 -1.790
ENSG00000100823 E024 31.77225 7.483078e-04 1.191207e-11 2.448682e-10 14 20455735 20455737 3 + 1.718 1.317 -1.373
ENSG00000100823 E025 43.13892 3.990880e-03 4.733996e-12 1.038973e-10 14 20455738 20455773 36 + 1.847 1.439 -1.388
ENSG00000100823 E026 27.89676 8.692093e-04 1.211325e-18 6.620943e-17 14 20455774 20455801 28 + 1.728 1.162 -1.957
ENSG00000100823 E027 49.14545 4.562893e-04 1.206314e-22 1.034552e-20 14 20455802 20455913 112 + 1.933 1.459 -1.607
ENSG00000100823 E028 1672.05303 7.923431e-05 3.479870e-03 1.166630e-02 14 20455914 20456006 93 + 3.174 3.217 0.143
ENSG00000100823 E029 1781.13104 6.458694e-05 1.260946e-03 4.846272e-03 14 20456007 20456101 95 + 3.201 3.246 0.150
ENSG00000100823 E030 2741.40827 3.896397e-04 8.187136e-02 1.624981e-01 14 20456668 20456860 193 + 3.395 3.425 0.102
ENSG00000100823 E031 1730.78795 1.331913e-04 1.297763e-03 4.969121e-03 14 20456991 20457059 69 + 3.187 3.234 0.157
ENSG00000100823 E032 1032.92455 8.940176e-05 1.019832e-11 2.120094e-10 14 20457060 20457077 18 + 2.927 3.026 0.331
ENSG00000100823 E033 1321.75767 7.679473e-05 1.413984e-08 1.695626e-07 14 20457078 20457122 45 + 3.050 3.127 0.257
ENSG00000100823 E034 4147.60696 1.224778e-03 4.207934e-08 4.608779e-07 14 20457123 20457772 650 + 3.526 3.621 0.316