ENSG00000100815

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000267622 ENSG00000100815 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIP11 protein_coding protein_coding 6.109663 1.493972 9.391467 0.05550385 0.5983647 2.644109 2.2300261 0.5950710 4.2514285 0.007129548 0.19964249 2.8161607 0.3565875 0.3990667 0.45703333 0.05796667 0.754826723 0.001299705 FALSE TRUE
ENST00000554357 ENSG00000100815 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIP11 protein_coding protein_coding 6.109663 1.493972 9.391467 0.05550385 0.5983647 2.644109 2.7688281 0.4288689 4.1200429 0.218766311 0.17364455 3.2342949 0.4310167 0.2771000 0.44166667 0.16456667 0.675543934 0.001299705 FALSE TRUE
ENST00000555105 ENSG00000100815 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIP11 protein_coding processed_transcript 6.109663 1.493972 9.391467 0.05550385 0.5983647 2.644109 0.4155710 0.4700317 0.3281455 0.172089280 0.02934605 -0.5054853 0.1416667 0.3238333 0.03486667 -0.28896667 0.001299705 0.001299705   FALSE
ENST00000555516 ENSG00000100815 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIP11 protein_coding protein_coding 6.109663 1.493972 9.391467 0.05550385 0.5983647 2.644109 0.5853969 0.0000000 0.6334470 0.000000000 0.63344697 6.0077493 0.0508500 0.0000000 0.05983333 0.05983333 1.000000000 0.001299705   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100815 E001 173.465729 0.0029845536 2.149197e-02 5.462873e-02 14 91965991 91969512 3522 - 2.084 2.182 0.330
ENSG00000100815 E002 65.476484 0.0004299383 8.409687e-16 3.209488e-14 14 91969513 91969893 381 - 1.587 1.993 1.374
ENSG00000100815 E003 34.932996 0.0006300917 2.270494e-10 3.765217e-09 14 91972717 91972861 145 - 1.313 1.745 1.481
ENSG00000100815 E004 43.052860 0.0005295025 1.059536e-03 4.164870e-03 14 91974627 91974743 117 - 1.459 1.682 0.761
ENSG00000100815 E005 45.876104 0.0020070346 1.106937e-01 2.065485e-01 14 91975172 91975286 115 - 1.507 1.626 0.404
ENSG00000100815 E006 43.716964 0.0014500994 2.457138e-02 6.099444e-02 14 91976108 91976189 82 - 1.481 1.642 0.550
ENSG00000100815 E007 0.294498 0.3351710983 1.000000e+00   14 91977126 91977248 123 - 0.098 0.000 -8.238
ENSG00000100815 E008 37.246537 0.0010168961 7.630460e-01 8.465188e-01 14 91988284 91988383 100 - 1.441 1.470 0.101
ENSG00000100815 E009 35.700727 0.0006638826 5.410631e-01 6.721051e-01 14 91993809 91993912 104 - 1.417 1.471 0.186
ENSG00000100815 E010 36.486182 0.0005851249 4.315170e-02 9.682368e-02 14 91995352 91995515 164 - 1.404 1.560 0.535
ENSG00000100815 E011 51.405512 0.0086760399 1.385638e-01 2.461092e-01 14 91999240 91999433 194 - 1.556 1.677 0.414
ENSG00000100815 E012 47.553101 0.0004599189 7.522038e-01 8.384784e-01 14 91999968 92000108 141 - 1.542 1.569 0.095
ENSG00000100815 E013 355.596133 0.0001962437 1.397961e-12 3.343934e-11 14 92003419 92006448 3030 - 2.432 2.253 -0.596
ENSG00000100815 E014 36.810972 0.0005914060 2.542725e-07 2.388495e-06 14 92007640 92007852 213 - 1.490 0.932 -1.984
ENSG00000100815 E015 22.842577 0.0009734385 3.648506e-03 1.215081e-02 14 92010986 92011072 87 - 1.277 0.932 -1.245
ENSG00000100815 E016 19.522120 0.0024471224 3.610778e-03 1.204103e-02 14 92011755 92011795 41 - 1.218 0.837 -1.401
ENSG00000100815 E017 44.834268 0.0004784284 1.715716e-05 1.080324e-04 14 92014215 92014577 363 - 1.563 1.184 -1.318
ENSG00000100815 E018 27.837435 0.0007968023 4.021384e-05 2.316677e-04 14 92015696 92015832 137 - 1.370 0.887 -1.741
ENSG00000100815 E019 17.702556 0.0012524115 4.977746e-06 3.544385e-05 14 92015833 92015861 29 - 1.198 0.428 -3.136
ENSG00000100815 E020 20.990798 0.0035134233 1.560944e-03 5.832897e-03 14 92017682 92017750 69 - 1.250 0.837 -1.513
ENSG00000100815 E021 42.222316 0.0005322826 3.585674e-06 2.639065e-05 14 92021556 92021831 276 - 1.542 1.106 -1.524
ENSG00000100815 E022 23.646412 0.0008212131 2.109857e-03 7.565033e-03 14 92025310 92025420 111 - 1.294 0.932 -1.305
ENSG00000100815 E023 5.389325 0.0938424929 1.523998e-05 9.710971e-05 14 92030541 92030776 236 - 0.442 1.238 3.208
ENSG00000100815 E024 22.586918 0.0008265036 9.165009e-01 9.512266e-01 14 92033192 92033253 62 - 1.234 1.250 0.057
ENSG00000100815 E025 64.595445 0.0004621285 1.455601e-04 7.280580e-04 14 92039547 92040494 948 - 1.637 1.849 0.717
ENSG00000100815 E026 0.147249 0.0425303558 8.404042e-01   14 92040651 92040879 229 - 0.052 0.000 -8.646
ENSG00000100815 E027 0.000000       14 92040880 92040971 92 -