ENSG00000100814

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000353689 ENSG00000100814 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNB1IP1 protein_coding protein_coding 50.52292 37.83879 83.56195 9.462497 2.786196 1.142772 6.680928 8.435600 5.971892 3.3688310 0.3354207 -0.4975981 0.16203333 0.20546667 0.07190000 -0.13356667 0.000817512 1.743475e-14 FALSE TRUE
ENST00000358932 ENSG00000100814 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNB1IP1 protein_coding protein_coding 50.52292 37.83879 83.56195 9.462497 2.786196 1.142772 36.645901 26.343822 63.511968 5.6720168 3.0730786 1.2692434 0.70131250 0.70950000 0.75926667 0.04976667 0.490179808 1.743475e-14 FALSE TRUE
ENST00000554047 ENSG00000100814 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNB1IP1 protein_coding nonsense_mediated_decay 50.52292 37.83879 83.56195 9.462497 2.786196 1.142772 2.869741 1.407157 4.408037 0.1947664 0.2192015 1.6404056 0.05677083 0.03956667 0.05306667 0.01350000 0.315559533 1.743475e-14   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100814 E001 0.7415677 0.0230931218 2.990561e-01 4.405372e-01 14 20311368 20311369 2 - 0.172 0.363 1.429
ENSG00000100814 E002 3.0558806 0.0052610860 5.103278e-03 1.621236e-02 14 20311370 20311377 8 - 0.390 0.824 1.963
ENSG00000100814 E003 15.4453736 0.0136916642 1.362670e-10 2.351984e-09 14 20311378 20311394 17 - 0.818 1.509 2.488
ENSG00000100814 E004 52.7149068 0.0013970691 1.124960e-13 3.172376e-12 14 20311395 20311428 34 - 1.543 1.928 1.304
ENSG00000100814 E005 514.6488875 0.0007493096 2.973240e-19 1.743335e-17 14 20311429 20311682 254 - 2.633 2.811 0.591
ENSG00000100814 E006 298.6830791 0.0001446468 4.955525e-06 3.529491e-05 14 20311683 20311703 21 - 2.435 2.537 0.338
ENSG00000100814 E007 359.4596709 0.0001868709 1.323705e-03 5.055784e-03 14 20311704 20311752 49 - 2.530 2.599 0.229
ENSG00000100814 E008 531.3423568 0.0005497930 7.628235e-03 2.284419e-02 14 20313468 20313636 169 - 2.704 2.759 0.183
ENSG00000100814 E009 471.2936908 0.0001504717 4.692709e-01 6.085258e-01 14 20313637 20313801 165 - 2.668 2.688 0.066
ENSG00000100814 E010 42.2937832 0.0006445622 7.046035e-04 2.915411e-03 14 20314211 20314649 439 - 1.699 1.511 -0.639
ENSG00000100814 E011 27.1856278 0.0014239293 8.900224e-03 2.603123e-02 14 20315485 20315618 134 - 1.512 1.333 -0.619
ENSG00000100814 E012 18.1650688 0.0010229458 2.316682e-08 2.667584e-07 14 20315781 20315850 70 - 1.422 0.902 -1.865
ENSG00000100814 E013 459.9372438 0.0001309292 1.383642e-02 3.785392e-02 14 20316227 20316413 187 - 2.677 2.643 -0.115
ENSG00000100814 E014 351.8805693 0.0001717933 1.901601e-06 1.486620e-05 14 20316414 20316511 98 - 2.580 2.493 -0.291
ENSG00000100814 E015 275.4210538 0.0002103673 2.034401e-03 7.333202e-03 14 20316512 20316560 49 - 2.465 2.403 -0.207
ENSG00000100814 E016 1.4694955 0.0128986533 6.299445e-02 1.316984e-01 14 20317596 20317793 198 - 0.503 0.157 -2.321
ENSG00000100814 E017 1.9155089 0.0153018220 1.959013e-02 5.060598e-02 14 20317794 20317794 1 - 0.592 0.157 -2.736
ENSG00000100814 E018 3.4311131 0.0046338301 5.037331e-02 1.098327e-01 14 20317795 20317974 180 - 0.749 0.439 -1.399
ENSG00000100814 E019 0.8921407 0.0130506474 4.497707e-02 1.001536e-01 14 20318256 20318470 215 - 0.390 0.001 -10.214
ENSG00000100814 E020 1.6994866 0.0105950251 2.024488e-01 3.292780e-01 14 20319051 20319103 53 - 0.503 0.273 -1.320
ENSG00000100814 E021 11.2213105 0.0390573207 3.761829e-01 5.205401e-01 14 20320288 20320392 105 - 1.040 1.144 0.377
ENSG00000100814 E022 271.8594002 0.0001678025 1.610440e-02 4.296842e-02 14 20325539 20325588 50 - 2.454 2.408 -0.153
ENSG00000100814 E023 273.2687593 0.0002264721 8.096855e-03 2.402576e-02 14 20325589 20325650 62 - 2.459 2.407 -0.174
ENSG00000100814 E024 141.7656584 0.0002945521 7.267004e-05 3.929982e-04 14 20325651 20325653 3 - 2.199 2.083 -0.389
ENSG00000100814 E025 242.7536090 0.0002224957 1.490665e-03 5.606219e-03 14 20326716 20326793 78 - 2.413 2.344 -0.230
ENSG00000100814 E026 217.9424020 0.0003462997 8.622497e-02 1.693560e-01 14 20329174 20329223 50 - 2.354 2.316 -0.126
ENSG00000100814 E027 276.7554289 0.0002276646 1.272225e-05 8.251823e-05 14 20329224 20329373 150 - 2.476 2.384 -0.307
ENSG00000100814 E028 1.3455410 0.0525018622 1.092771e-01 2.044907e-01 14 20329374 20329380 7 - 0.469 0.157 -2.157
ENSG00000100814 E029 2.1608255 0.0439531032 9.998491e-01 1.000000e+00 14 20330526 20330888 363 - 0.502 0.502 -0.001
ENSG00000100814 E030 1.1436731 0.0112919262 2.644951e-01 4.024561e-01 14 20332844 20333253 410 - 0.237 0.439 1.264
ENSG00000100814 E031 103.8752056 0.0016017197 7.345360e-05 3.967487e-04 14 20333254 20333312 59 - 2.074 1.912 -0.545
ENSG00000100814 E032 2.3906897 0.0071317065 7.531458e-01 8.391778e-01 14 20342610 20342758 149 - 0.503 0.559 0.265