ENSG00000100813

Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338631 ENSG00000100813 HEK293_OSMI2_2hA HEK293_TMG_2hB ACIN1 protein_coding protein_coding 218.0562 237.5749 175.9962 5.354848 2.435597 -0.432817 48.45939 82.024488 29.897819 2.8563961 1.8842569 -1.455707862 0.21470417 0.34510000 0.169666667 -0.17543333 1.432424e-16 2.084226e-33 FALSE TRUE
ENST00000357481 ENSG00000100813 HEK293_OSMI2_2hA HEK293_TMG_2hB ACIN1 protein_coding protein_coding 218.0562 237.5749 175.9962 5.354848 2.435597 -0.432817 14.68870 20.171103 9.953978 3.1999131 0.9514304 -1.018211320 0.06551667 0.08513333 0.056733333 -0.02840000 3.102742e-01 2.084226e-33 FALSE TRUE
ENST00000397341 ENSG00000100813 HEK293_OSMI2_2hA HEK293_TMG_2hB ACIN1 protein_coding protein_coding 218.0562 237.5749 175.9962 5.354848 2.435597 -0.432817 22.32034 17.738906 18.627831 2.0028058 0.4308011 0.070503896 0.10440417 0.07460000 0.105900000 0.03130000 9.414387e-02 2.084226e-33 FALSE TRUE
ENST00000473758 ENSG00000100813 HEK293_OSMI2_2hA HEK293_TMG_2hB ACIN1 protein_coding nonsense_mediated_decay 218.0562 237.5749 175.9962 5.354848 2.435597 -0.432817 11.93973 9.962817 9.955418 0.4029611 0.3922402 -0.001070714 0.05466250 0.04193333 0.056633333 0.01470000 2.876397e-02 2.084226e-33 FALSE TRUE
ENST00000553501 ENSG00000100813 HEK293_OSMI2_2hA HEK293_TMG_2hB ACIN1 protein_coding retained_intron 218.0562 237.5749 175.9962 5.354848 2.435597 -0.432817 15.23666 9.031450 14.433910 0.5042308 0.2553226 0.675835229 0.07110000 0.03793333 0.082100000 0.04416667 2.995334e-16 2.084226e-33 FALSE TRUE
ENST00000554708 ENSG00000100813 HEK293_OSMI2_2hA HEK293_TMG_2hB ACIN1 protein_coding retained_intron 218.0562 237.5749 175.9962 5.354848 2.435597 -0.432817 29.54867 27.320358 28.871307 2.7243290 0.4523559 0.079631702 0.13924583 0.11463333 0.164100000 0.04946667 8.439995e-03 2.084226e-33 FALSE TRUE
ENST00000557039 ENSG00000100813 HEK293_OSMI2_2hA HEK293_TMG_2hB ACIN1 protein_coding retained_intron 218.0562 237.5749 175.9962 5.354848 2.435597 -0.432817 14.84582 13.631878 13.069159 0.4455912 1.3815830 -0.060772509 0.06771250 0.05733333 0.074400000 0.01706667 3.510327e-01 2.084226e-33   FALSE
MSTRG.9215.2 ENSG00000100813 HEK293_OSMI2_2hA HEK293_TMG_2hB ACIN1 protein_coding   218.0562 237.5749 175.9962 5.354848 2.435597 -0.432817 10.36369 22.628045 1.479328 4.0476375 0.1889892 -3.926015716 0.04372083 0.09573333 0.008433333 -0.08730000 8.862445e-14 2.084226e-33 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.