ENSG00000100764

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261303 ENSG00000100764 HEK293_OSMI2_2hA HEK293_TMG_2hB PSMC1 protein_coding protein_coding 45.11615 29.58473 64.41125 1.256056 1.689815 1.122197 10.75047 10.74180 12.15529 1.5245808 0.5946979 0.1781928 0.2640417 0.3614000 0.1886 -0.1728000 0.001066704 6.616536e-06 FALSE TRUE
ENST00000555679 ENSG00000100764 HEK293_OSMI2_2hA HEK293_TMG_2hB PSMC1 protein_coding retained_intron 45.11615 29.58473 64.41125 1.256056 1.689815 1.122197 32.05627 17.36101 49.24183 0.8724125 1.2342233 1.5034959 0.6834458 0.5892333 0.7646 0.1753667 0.001409756 6.616536e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100764 E001 0.000000       14 90256527 90256527 1 +      
ENSG00000100764 E002 6.720196 0.0023777600 2.482065e-01 3.838153e-01 14 90256528 90256552 25 + 0.952 0.819 -0.509
ENSG00000100764 E003 6.867445 0.0023050074 2.054292e-01 3.329438e-01 14 90256553 90256553 1 + 0.965 0.819 -0.556
ENSG00000100764 E004 87.480031 0.0009238409 1.912971e-04 9.266580e-04 14 90256554 90256577 24 + 2.005 1.858 -0.495
ENSG00000100764 E005 169.187989 0.0002895252 2.710104e-12 6.202984e-11 14 90256578 90256592 15 + 2.306 2.111 -0.652
ENSG00000100764 E006 229.113830 0.0034028503 3.766157e-02 8.669663e-02 14 90256593 90256600 8 + 2.393 2.315 -0.260
ENSG00000100764 E007 385.921272 0.0004769108 2.502168e-01 3.861958e-01 14 90259160 90259213 54 + 2.596 2.577 -0.063
ENSG00000100764 E008 470.373753 0.0001137824 5.159311e-03 1.636226e-02 14 90260115 90260211 97 + 2.692 2.653 -0.130
ENSG00000100764 E009 589.159741 0.0001333860 5.582782e-01 6.865463e-01 14 90263318 90263442 125 + 2.774 2.772 -0.005
ENSG00000100764 E010 3.140969 0.0048337383 1.524932e-02 4.105063e-02 14 90263443 90263661 219 + 0.741 0.342 -1.909
ENSG00000100764 E011 395.504296 0.0002654909 1.274724e-03 4.893070e-03 14 90263662 90263669 8 + 2.624 2.570 -0.179
ENSG00000100764 E012 519.083178 0.0011364066 1.460491e-02 3.960500e-02 14 90263670 90263800 131 + 2.738 2.692 -0.154
ENSG00000100764 E013 358.341426 0.0012111655 1.359505e-01 2.424153e-01 14 90263801 90263847 47 + 2.571 2.539 -0.106
ENSG00000100764 E014 1.516636 0.0089651744 1.754746e-01 2.952898e-01 14 90263848 90263944 97 + 0.494 0.255 -1.409
ENSG00000100764 E015 464.233184 0.0001589580 1.639792e-01 2.803177e-01 14 90264041 90264169 129 + 2.677 2.660 -0.056
ENSG00000100764 E016 231.995744 0.0020782434 2.789468e-02 6.780471e-02 14 90265070 90265166 97 + 2.334 2.403 0.230
ENSG00000100764 E017 10.085626 0.0016769102 6.482104e-01 7.597669e-01 14 90267476 90268223 748 + 1.065 1.025 -0.146
ENSG00000100764 E018 509.395317 0.0001265492 1.515165e-02 4.083005e-02 14 90268224 90268413 190 + 2.689 2.735 0.152
ENSG00000100764 E019 811.918889 0.0010014892 2.057755e-03 7.404424e-03 14 90269397 90269548 152 + 2.883 2.944 0.204
ENSG00000100764 E020 26.506155 0.0007450697 2.564609e-06 1.949566e-05 14 90269549 90270197 649 + 1.559 1.230 -1.142
ENSG00000100764 E021 585.736267 0.0015986319 1.226412e-04 6.259337e-04 14 90270198 90270352 155 + 2.726 2.819 0.309
ENSG00000100764 E022 298.177668 0.0002111761 1.169473e-15 4.375062e-14 14 90272273 90275429 3157 + 2.392 2.566 0.581