ENSG00000100744

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000438650 ENSG00000100744 HEK293_OSMI2_2hA HEK293_TMG_2hB GSKIP protein_coding protein_coding 9.007604 2.736991 17.30096 0.6399603 0.3573063 2.655761 0.39669715 0.1345697 0.49490345 0.08286308 0.05644400 1.8042424 0.06138333 0.0549000 0.028600000 -0.02630000 8.558026e-01 7.257081e-11 FALSE TRUE
ENST00000554182 ENSG00000100744 HEK293_OSMI2_2hA HEK293_TMG_2hB GSKIP protein_coding protein_coding 9.007604 2.736991 17.30096 0.6399603 0.3573063 2.655761 3.23981356 0.7711680 6.25936151 0.29026406 0.96217228 3.0046138 0.32775000 0.2688667 0.363200000 0.09433333 6.762104e-01 7.257081e-11 FALSE TRUE
ENST00000555181 ENSG00000100744 HEK293_OSMI2_2hA HEK293_TMG_2hB GSKIP protein_coding protein_coding 9.007604 2.736991 17.30096 0.6399603 0.3573063 2.655761 4.64529751 0.8306578 9.42361513 0.59650877 1.47928600 3.4882203 0.42573750 0.2445667 0.542966667 0.29840000 4.254731e-01 7.257081e-11 FALSE TRUE
ENST00000555757 ENSG00000100744 HEK293_OSMI2_2hA HEK293_TMG_2hB GSKIP protein_coding protein_coding 9.007604 2.736991 17.30096 0.6399603 0.3573063 2.655761 0.06215731 0.4492022 0.04805621 0.44920225 0.04805621 -2.9836075 0.02730000 0.2156667 0.002733333 -0.21293333 7.855935e-01 7.257081e-11 FALSE TRUE
ENST00000556095 ENSG00000100744 HEK293_OSMI2_2hA HEK293_TMG_2hB GSKIP protein_coding protein_coding 9.007604 2.736991 17.30096 0.6399603 0.3573063 2.655761 0.46504040 0.5513935 0.39333021 0.05478065 0.02020826 -0.4770508 0.14240417 0.2159667 0.022800000 -0.19316667 7.257081e-11 7.257081e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100744 E001 1.4768824 0.0092351951 7.126112e-01 8.092920e-01 14 96363452 96363525 74 + 0.311 0.418 0.630
ENSG00000100744 E002 28.4079247 0.0008539612 2.518499e-02 6.225173e-02 14 96363526 96363556 31 + 1.368 1.214 -0.539
ENSG00000100744 E003 31.8496349 0.0012102976 1.540989e-02 4.142284e-02 14 96363557 96363568 12 + 1.417 1.255 -0.562
ENSG00000100744 E004 2.5014176 0.0426796785 1.275972e-03 4.897153e-03 14 96363569 96363723 155 + 0.282 0.875 2.829
ENSG00000100744 E005 7.5230408 0.0089531680 5.750603e-09 7.426275e-08 14 96363724 96363925 202 + 0.573 1.327 2.882
ENSG00000100744 E006 22.8263013 0.0101546426 5.977357e-28 8.419273e-26 14 96363926 96365266 1341 + 0.885 1.848 3.383
ENSG00000100744 E007 0.2924217 0.0277247397 1.000000e+00   14 96378938 96379059 122 + 0.101 0.000 -8.617
ENSG00000100744 E008 33.0150329 0.0089769563 6.087424e-04 2.565102e-03 14 96379688 96379701 14 + 1.446 1.143 -1.062
ENSG00000100744 E009 42.3651721 0.0033482953 3.748105e-06 2.746131e-05 14 96379702 96379734 33 + 1.555 1.192 -1.262
ENSG00000100744 E010 44.2035773 0.0008136667 3.804730e-07 3.445317e-06 14 96379735 96379755 21 + 1.574 1.192 -1.323
ENSG00000100744 E011 29.5240751 0.0077667767 1.294514e-04 6.564638e-04 14 96379756 96379788 33 + 1.404 1.029 -1.329
ENSG00000100744 E012 0.4502799 0.0299955241 1.000000e+00 1.000000e+00 14 96379789 96380292 504 + 0.144 0.000 -9.182
ENSG00000100744 E013 136.1336249 0.0002679419 7.519985e-06 5.137906e-05 14 96382247 96382505 259 + 2.027 1.901 -0.425
ENSG00000100744 E014 383.6469728 0.0037736562 6.535891e-05 3.576766e-04 14 96385523 96387288 1766 + 2.432 2.565 0.444