ENSG00000100731

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000304743 ENSG00000100731 HEK293_OSMI2_2hA HEK293_TMG_2hB PCNX1 protein_coding protein_coding 8.801453 3.609513 10.89302 0.487936 0.6661572 1.59086 0.7704927 0.12108637 1.2849234 0.06169571 0.08522002 3.3042773 0.07822917 0.03023333 0.118700000 0.08846667 6.235454e-03 3.554865e-06 FALSE TRUE
ENST00000439984 ENSG00000100731 HEK293_OSMI2_2hA HEK293_TMG_2hB PCNX1 protein_coding protein_coding 8.801453 3.609513 10.89302 0.487936 0.6661572 1.59086 0.6378197 0.01872802 1.8502811 0.01872802 0.30502287 6.0169184 0.05662083 0.00430000 0.173700000 0.16940000 3.554865e-06 3.554865e-06 FALSE TRUE
ENST00000554691 ENSG00000100731 HEK293_OSMI2_2hA HEK293_TMG_2hB PCNX1 protein_coding protein_coding 8.801453 3.609513 10.89302 0.487936 0.6661572 1.59086 0.1409251 0.62666154 0.0639189 0.35811467 0.06391890 -3.1065115 0.03304583 0.18890000 0.006433333 -0.18246667 2.654093e-01 3.554865e-06 FALSE TRUE
MSTRG.9831.11 ENSG00000100731 HEK293_OSMI2_2hA HEK293_TMG_2hB PCNX1 protein_coding   8.801453 3.609513 10.89302 0.487936 0.6661572 1.59086 1.8965120 1.12623237 1.5182187 0.21805978 0.38526071 0.4275931 0.24920833 0.31323333 0.136533333 -0.17670000 2.156888e-02 3.554865e-06 FALSE TRUE
MSTRG.9831.4 ENSG00000100731 HEK293_OSMI2_2hA HEK293_TMG_2hB PCNX1 protein_coding   8.801453 3.609513 10.89302 0.487936 0.6661572 1.59086 4.2348154 1.60784111 4.9765602 0.42536346 0.16391481 1.6239750 0.47437500 0.43426667 0.459266667 0.02500000 9.059956e-01 3.554865e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100731 E001 0.0000000       14 70907405 70907458 54 +      
ENSG00000100731 E002 0.5891098 0.0183953898 2.297415e-01 3.621467e-01 14 70907459 70907531 73 + 0.255 0.000 -12.283
ENSG00000100731 E003 11.3146296 0.0465591937 5.741470e-01 7.000124e-01 14 70907532 70907669 138 + 1.087 0.999 -0.320
ENSG00000100731 E004 10.3964526 0.0279720248 5.642417e-01 6.915599e-01 14 70907670 70907738 69 + 1.050 0.976 -0.272
ENSG00000100731 E005 23.9241284 0.0022136959 2.213302e-03 7.884459e-03 14 70907739 70908003 265 + 1.431 1.184 -0.864
ENSG00000100731 E006 0.1451727 0.0438244956 1.000000e+00   14 70942873 70942940 68 + 0.079 0.000 -10.272
ENSG00000100731 E007 0.1515154 0.0436335787 1.000000e+00   14 70946882 70946914 33 + 0.079 0.000 -10.273
ENSG00000100731 E008 42.0975704 0.0261877492 6.290506e-05 3.456758e-04 14 70946915 70947123 209 + 1.694 1.282 -1.419
ENSG00000100731 E009 37.0167490 0.0236365993 1.043592e-03 4.109537e-03 14 70962226 70962331 106 + 1.626 1.294 -1.142
ENSG00000100731 E010 0.0000000       14 70965365 70965369 5 +      
ENSG00000100731 E011 0.0000000       14 70965370 70965432 63 +      
ENSG00000100731 E012 23.8827652 0.0156586816 2.956223e-03 1.013312e-02 14 70968198 70968243 46 + 1.438 1.137 -1.056
ENSG00000100731 E013 35.8759783 0.0095100690 4.613007e-04 2.011556e-03 14 70969021 70969110 90 + 1.605 1.315 -0.997
ENSG00000100731 E014 0.3686942 0.0420559388 4.834085e-01 6.214100e-01 14 70969111 70969271 161 + 0.079 0.185 1.409
ENSG00000100731 E015 0.4396707 0.0275412129 3.695568e-01 5.139585e-01 14 70969859 70969999 141 + 0.204 0.000 -11.857
ENSG00000100731 E016 217.0132000 0.0027646505 4.703666e-13 1.216015e-11 14 70976942 70978377 1436 + 2.373 2.114 -0.865
ENSG00000100731 E017 64.2992261 0.0014079834 8.124161e-06 5.508977e-05 14 70978378 70978648 271 + 1.844 1.615 -0.774
ENSG00000100731 E018 6.2344301 0.0025751361 8.659535e-01 9.176778e-01 14 70988567 70988569 3 + 0.833 0.866 0.130
ENSG00000100731 E019 19.0450681 0.0011773598 3.424425e-01 4.864447e-01 14 70988570 70988699 130 + 1.297 1.227 -0.244
ENSG00000100731 E020 16.8388219 0.0012647478 7.459848e-01 8.338681e-01 14 70995741 70995843 103 + 1.230 1.213 -0.060
ENSG00000100731 E021 16.6535577 0.0010624677 5.244413e-01 6.579636e-01 14 70995844 70995925 82 + 1.231 1.185 -0.163
ENSG00000100731 E022 29.3073032 0.0012204380 1.827070e-02 4.772208e-02 14 71009634 71009724 91 + 1.497 1.335 -0.559
ENSG00000100731 E023 0.0000000       14 71009725 71009868 144 +      
ENSG00000100731 E024 30.5638731 0.0007341051 5.997185e-03 1.860252e-02 14 71011492 71011549 58 + 1.521 1.335 -0.642
ENSG00000100731 E025 0.3289534 0.0290965113 4.867621e-01   14 71011550 71012838 1289 + 0.079 0.185 1.405
ENSG00000100731 E026 21.2123191 0.0013745376 1.437807e-02 3.908347e-02 14 71012985 71012999 15 + 1.369 1.169 -0.703
ENSG00000100731 E027 27.5004883 0.0007492025 4.194152e-04 1.848782e-03 14 71013000 71013030 31 + 1.491 1.227 -0.918
ENSG00000100731 E028 57.3510982 0.0004286687 2.226272e-04 1.060419e-03 14 71013031 71013202 172 + 1.784 1.598 -0.630
ENSG00000100731 E029 51.1337751 0.0082286719 2.648964e-02 6.493011e-02 14 71019009 71019162 154 + 1.727 1.580 -0.501
ENSG00000100731 E030 31.1011864 0.0097034676 1.871939e-01 3.102154e-01 14 71023200 71023232 33 + 1.505 1.404 -0.347
ENSG00000100731 E031 35.1412222 0.0007180340 2.763232e-03 9.562436e-03 14 71026117 71026194 78 + 1.578 1.386 -0.660
ENSG00000100731 E032 28.7115755 0.0010644053 5.395365e-04 2.308190e-03 14 71026195 71026288 94 + 1.508 1.254 -0.882
ENSG00000100731 E033 20.7376378 0.0040774499 2.338088e-02 5.854165e-02 14 71026772 71026821 50 + 1.362 1.169 -0.679
ENSG00000100731 E034 19.4882442 0.0009452653 3.976126e-04 1.765162e-03 14 71026822 71026882 61 + 1.362 1.044 -1.130
ENSG00000100731 E035 0.0000000       14 71026883 71027202 320 +      
ENSG00000100731 E036 28.0139373 0.0007081962 5.938924e-03 1.844838e-02 14 71028700 71028791 92 + 1.486 1.291 -0.676
ENSG00000100731 E037 39.8950808 0.0008937446 3.162445e-01 4.589941e-01 14 71033429 71033538 110 + 1.598 1.549 -0.167
ENSG00000100731 E038 41.2165577 0.0023024236 1.602463e-01 2.754526e-01 14 71033931 71034036 106 + 1.619 1.542 -0.262
ENSG00000100731 E039 34.4375054 0.0008256579 6.800120e-02 1.400498e-01 14 71036065 71036157 93 + 1.549 1.439 -0.378
ENSG00000100731 E040 45.3658430 0.0006266189 4.852647e-01 6.231666e-01 14 71045133 71045283 151 + 1.647 1.621 -0.092
ENSG00000100731 E041 39.9794645 0.0007064553 6.861915e-01 7.887588e-01 14 71046964 71047105 142 + 1.573 1.609 0.124
ENSG00000100731 E042 44.8479462 0.0022271524 8.896558e-01 9.334748e-01 14 71047807 71047959 153 + 1.632 1.636 0.016
ENSG00000100731 E043 27.7093691 0.0051342160 3.207430e-01 4.639131e-01 14 71047960 71047984 25 + 1.451 1.384 -0.229
ENSG00000100731 E044 21.1319994 0.0175987894 6.861892e-01 7.887588e-01 14 71050652 71050657 6 + 1.302 1.353 0.178
ENSG00000100731 E045 39.6941355 0.0005575420 3.276733e-01 4.711456e-01 14 71050658 71050760 103 + 1.556 1.626 0.238
ENSG00000100731 E046 46.3288360 0.0031527424 8.060302e-01 8.766894e-01 14 71051883 71052012 130 + 1.645 1.642 -0.011
ENSG00000100731 E047 0.3289534 0.0290965113 4.867621e-01   14 71053297 71053412 116 + 0.079 0.185 1.405
ENSG00000100731 E048 41.4623411 0.0176563317 1.018987e-01 1.933863e-01 14 71055504 71055562 59 + 1.635 1.501 -0.456
ENSG00000100731 E049 71.0570643 0.0038165385 7.278902e-01 8.204530e-01 14 71057509 71057724 216 + 1.830 1.823 -0.022
ENSG00000100731 E050 0.1515154 0.0436335787 1.000000e+00   14 71060668 71060742 75 + 0.079 0.000 -10.273
ENSG00000100731 E051 83.7322544 0.0003675828 7.679648e-02 1.543654e-01 14 71073545 71073798 254 + 1.872 1.956 0.285
ENSG00000100731 E052 78.9644377 0.0004467490 6.000659e-02 1.266115e-01 14 71076189 71076419 231 + 1.844 1.935 0.308
ENSG00000100731 E053 0.6017953 0.1655655676 2.793487e-01 4.190894e-01 14 71078651 71078739 89 + 0.256 0.000 -12.277
ENSG00000100731 E054 50.2166980 0.0007713560 9.947447e-02 1.896782e-01 14 71088330 71088430 101 + 1.645 1.744 0.336
ENSG00000100731 E055 61.2757600 0.0013543342 5.422303e-02 1.166376e-01 14 71089192 71089342 151 + 1.729 1.837 0.364
ENSG00000100731 E056 1.7265419 0.0119099450 4.593534e-01 5.995310e-01 14 71092554 71093845 1292 + 0.447 0.314 -0.764
ENSG00000100731 E057 74.4909479 0.0026278107 2.013933e-02 5.177689e-02 14 71101990 71102220 231 + 1.807 1.932 0.418
ENSG00000100731 E058 104.2525955 0.0023685188 9.481658e-04 3.781465e-03 14 71103395 71103669 275 + 1.941 2.090 0.500
ENSG00000100731 E059 93.6937928 0.0008822828 5.619013e-13 1.434643e-11 14 71105235 71105440 206 + 1.834 2.125 0.976
ENSG00000100731 E060 142.2258537 0.0008908524 1.803170e-12 4.236701e-11 14 71108604 71109019 416 + 2.037 2.278 0.805
ENSG00000100731 E061 42.1396551 0.0069664778 7.562084e-03 2.267584e-02 14 71109020 71109046 27 + 1.539 1.730 0.649
ENSG00000100731 E062 75.8625706 0.0078734064 4.552245e-05 2.590907e-04 14 71109452 71109592 141 + 1.763 2.015 0.846
ENSG00000100731 E063 47.7906012 0.0081197450 1.486662e-05 9.497343e-05 14 71109795 71109831 37 + 1.544 1.843 1.015
ENSG00000100731 E064 73.4185460 0.0166352709 3.820853e-04 1.705463e-03 14 71109832 71109982 151 + 1.737 2.011 0.920
ENSG00000100731 E065 441.3062752 0.0185136483 2.569411e-01 3.939649e-01 14 71109983 71115382 5400 + 2.591 2.661 0.233