ENSG00000100726

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262319 ENSG00000100726 HEK293_OSMI2_2hA HEK293_TMG_2hB TELO2 protein_coding protein_coding 83.84711 136.1049 51.99139 8.094556 2.430449 -1.388203 54.267730 97.699752 29.222930 6.468101 1.6552270 -1.7409081 0.6232292 0.71743333 0.56196667 -0.155466667 4.774709e-05 1.550806e-11 FALSE TRUE
ENST00000563676 ENSG00000100726 HEK293_OSMI2_2hA HEK293_TMG_2hB TELO2 protein_coding retained_intron 83.84711 136.1049 51.99139 8.094556 2.430449 -1.388203 7.789757 6.814772 7.529703 1.022833 0.6573730 0.1437269 0.1071917 0.04953333 0.14446667 0.094933333 1.550806e-11 1.550806e-11 FALSE FALSE
ENST00000568240 ENSG00000100726 HEK293_OSMI2_2hA HEK293_TMG_2hB TELO2 protein_coding retained_intron 83.84711 136.1049 51.99139 8.094556 2.430449 -1.388203 8.783243 11.671358 5.048958 1.754750 0.6511215 -1.2072957 0.1088542 0.08690000 0.09686667 0.009966667 8.514585e-01 1.550806e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100726 E001 1.768166 8.133366e-03 3.100284e-01 4.523912e-01 16 1493344 1493356 13 + 0.206 0.409 1.363
ENSG00000100726 E002 1.768166 8.133366e-03 3.100284e-01 4.523912e-01 16 1493357 1493358 2 + 0.206 0.409 1.363
ENSG00000100726 E003 3.129130 5.108800e-03 2.625666e-01 4.003545e-01 16 1493359 1493359 1 + 0.346 0.558 1.102
ENSG00000100726 E004 3.458084 4.992751e-03 4.758487e-01 6.145275e-01 16 1493360 1493364 5 + 0.451 0.578 0.610
ENSG00000100726 E005 4.344810 4.114906e-03 4.901258e-01 6.274860e-01 16 1493365 1493369 5 + 0.536 0.652 0.517
ENSG00000100726 E006 9.709063 2.381731e-03 2.566659e-01 3.936441e-01 16 1493370 1493377 8 + 1.031 0.892 -0.519
ENSG00000100726 E007 19.698919 2.358971e-02 2.971065e-01 4.384117e-01 16 1493378 1493392 15 + 1.298 1.183 -0.407
ENSG00000100726 E008 21.661579 2.348046e-02 1.009052e-01 1.918486e-01 16 1493393 1493398 6 + 1.383 1.207 -0.613
ENSG00000100726 E009 385.471090 1.037066e-02 1.866107e-03 6.809304e-03 16 1493399 1493605 207 + 2.605 2.446 -0.529
ENSG00000100726 E010 4.484325 9.004679e-02 2.069460e-02 5.294486e-02 16 1493865 1494052 188 + 0.951 0.521 -1.776
ENSG00000100726 E011 260.726259 9.826638e-03 3.591974e-03 1.198698e-02 16 1494246 1494280 35 + 2.431 2.278 -0.510
ENSG00000100726 E012 902.989541 3.680055e-03 2.237979e-04 1.065380e-03 16 1494281 1494616 336 + 2.939 2.826 -0.376
ENSG00000100726 E013 711.384347 3.411740e-03 5.696657e-01 6.961887e-01 16 1495346 1495623 278 + 2.757 2.744 -0.046
ENSG00000100726 E014 439.152547 1.673068e-04 1.941180e-01 3.189401e-01 16 1497036 1497104 69 + 2.560 2.529 -0.103
ENSG00000100726 E015 611.679522 1.232069e-04 1.005286e-01 1.912537e-01 16 1497361 1497508 148 + 2.656 2.683 0.089
ENSG00000100726 E016 529.016698 1.183339e-04 2.863661e-01 4.267648e-01 16 1499231 1499333 103 + 2.602 2.619 0.058
ENSG00000100726 E017 391.558693 3.683278e-03 2.650743e-01 4.030947e-01 16 1500096 1500164 69 + 2.452 2.496 0.146
ENSG00000100726 E018 587.681735 1.112873e-03 9.235324e-01 9.558225e-01 16 1500347 1500488 142 + 2.660 2.663 0.008
ENSG00000100726 E019 493.446681 2.416037e-03 8.034408e-01 8.748826e-01 16 1500563 1500645 83 + 2.580 2.588 0.028
ENSG00000100726 E020 502.657488 3.918203e-03 8.697806e-01 9.202695e-01 16 1500646 1500699 54 + 2.597 2.595 -0.007
ENSG00000100726 E021 557.839861 2.584018e-03 5.314483e-01 6.638941e-01 16 1501420 1501499 80 + 2.625 2.644 0.065
ENSG00000100726 E022 402.130600 1.537190e-03 2.652202e-01 4.032550e-01 16 1501663 1501679 17 + 2.524 2.491 -0.109
ENSG00000100726 E023 472.498224 1.606077e-03 1.950299e-01 3.200193e-01 16 1501680 1501706 27 + 2.596 2.560 -0.120
ENSG00000100726 E024 609.584217 1.243959e-03 4.832543e-01 6.212918e-01 16 1501707 1501764 58 + 2.692 2.675 -0.058
ENSG00000100726 E025 368.923353 1.559490e-04 4.895084e-01 6.269285e-01 16 1501765 1501773 9 + 2.475 2.456 -0.065
ENSG00000100726 E026 670.693733 9.418656e-05 1.839245e-01 3.061534e-01 16 1502047 1502135 89 + 2.702 2.722 0.065
ENSG00000100726 E027 721.944069 9.357896e-05 3.513966e-01 4.956226e-01 16 1502313 1502404 92 + 2.740 2.752 0.040
ENSG00000100726 E028 631.457633 1.523570e-04 1.782672e-03 6.544301e-03 16 1502645 1502731 87 + 2.648 2.703 0.182
ENSG00000100726 E029 440.613245 2.411374e-04 3.298469e-04 1.500180e-03 16 1502732 1502761 30 + 2.473 2.551 0.259
ENSG00000100726 E030 482.038672 1.595144e-04 8.823645e-02 1.724255e-01 16 1502931 1502961 31 + 2.550 2.582 0.107
ENSG00000100726 E031 522.651868 4.452390e-04 6.264590e-01 7.423998e-01 16 1502962 1503002 41 + 2.606 2.614 0.027
ENSG00000100726 E032 14.385471 1.196376e-03 5.303097e-08 5.686623e-07 16 1505139 1505409 271 + 1.434 0.937 -1.774
ENSG00000100726 E033 452.101610 7.431859e-04 6.535871e-01 7.640152e-01 16 1505410 1505440 31 + 2.543 2.552 0.030
ENSG00000100726 E034 971.428968 7.725523e-04 2.482110e-01 3.838191e-01 16 1505441 1505601 161 + 2.864 2.886 0.073
ENSG00000100726 E035 27.856713 7.726414e-04 1.852468e-09 2.611777e-08 16 1506225 1506237 13 + 1.657 1.239 -1.442
ENSG00000100726 E036 533.581586 1.302003e-04 1.700896e-01 2.883115e-01 16 1506238 1506272 35 + 2.600 2.623 0.079
ENSG00000100726 E037 615.919242 1.636298e-04 7.777721e-01 8.570001e-01 16 1506273 1506329 57 + 2.681 2.683 0.007
ENSG00000100726 E038 30.567957 9.626938e-03 3.252014e-14 9.922440e-13 16 1506330 1506333 4 + 1.792 1.197 -2.045
ENSG00000100726 E039 74.180282 2.048806e-03 2.812196e-31 5.132583e-29 16 1506334 1506483 150 + 2.142 1.594 -1.845
ENSG00000100726 E040 56.204126 7.446094e-03 1.804634e-12 4.239614e-11 16 1506484 1506533 50 + 1.968 1.519 -1.522
ENSG00000100726 E041 117.516652 2.746328e-03 2.719798e-27 3.603200e-25 16 1506534 1506827 294 + 2.289 1.833 -1.529
ENSG00000100726 E042 79.390247 5.394402e-04 8.441418e-23 7.329062e-21 16 1506828 1506951 124 + 2.100 1.677 -1.424
ENSG00000100726 E043 710.741077 3.314612e-04 4.793858e-01 6.177646e-01 16 1506952 1507051 100 + 2.737 2.747 0.036
ENSG00000100726 E044 580.532779 1.219725e-03 9.134843e-03 2.662004e-02 16 1507306 1507370 65 + 2.606 2.671 0.216
ENSG00000100726 E045 828.648094 1.093323e-03 6.211730e-05 3.418951e-04 16 1507601 1507716 116 + 2.739 2.829 0.297
ENSG00000100726 E046 1166.793744 1.457876e-03 1.755353e-06 1.382628e-05 16 1509830 1510050 221 + 2.874 2.981 0.356
ENSG00000100726 E047 1088.992393 3.947206e-03 3.398871e-04 1.539855e-03 16 1510051 1510457 407 + 2.834 2.953 0.398
ENSG00000100726 E048 16.282326 2.268467e-02 7.793764e-04 3.185144e-03 16 1510461 1510764 304 + 1.415 1.038 -1.334