ENSG00000100697

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343455 ENSG00000100697 HEK293_OSMI2_2hA HEK293_TMG_2hB DICER1 protein_coding protein_coding 9.721496 3.143914 15.14289 0.3196904 0.308619 2.264377 2.60891069 2.21272557 3.50138236 0.24786729 0.26242409 0.6597093 0.36430417 0.71940000 0.23073333 -0.48866667 1.157640e-02 2.693666e-11 FALSE TRUE
ENST00000393063 ENSG00000100697 HEK293_OSMI2_2hA HEK293_TMG_2hB DICER1 protein_coding protein_coding 9.721496 3.143914 15.14289 0.3196904 0.308619 2.264377 0.69499605 0.00000000 2.02338718 0.00000000 0.35869176 7.6677411 0.04621667 0.00000000 0.13280000 0.13280000 3.758616e-08 2.693666e-11 FALSE TRUE
ENST00000526495 ENSG00000100697 HEK293_OSMI2_2hA HEK293_TMG_2hB DICER1 protein_coding protein_coding 9.721496 3.143914 15.14289 0.3196904 0.308619 2.264377 2.73876657 0.00000000 3.95122288 0.00000000 0.59679240 8.6298021 0.22487917 0.00000000 0.26200000 0.26200000 2.693666e-11 2.693666e-11 FALSE TRUE
ENST00000527416 ENSG00000100697 HEK293_OSMI2_2hA HEK293_TMG_2hB DICER1 protein_coding processed_transcript 9.721496 3.143914 15.14289 0.3196904 0.308619 2.264377 0.22512972 0.00000000 0.00000000 0.00000000 0.00000000 0.0000000 0.05770833 0.00000000 0.00000000 0.00000000   2.693666e-11 FALSE TRUE
ENST00000529720 ENSG00000100697 HEK293_OSMI2_2hA HEK293_TMG_2hB DICER1 protein_coding protein_coding 9.721496 3.143914 15.14289 0.3196904 0.308619 2.264377 0.47672196 0.36293405 0.91992490 0.36293405 0.37558103 1.3181937 0.05995417 0.11486667 0.05983333 -0.05503333 6.656919e-01 2.693666e-11 FALSE TRUE
ENST00000531162 ENSG00000100697 HEK293_OSMI2_2hA HEK293_TMG_2hB DICER1 protein_coding protein_coding 9.721496 3.143914 15.14289 0.3196904 0.308619 2.264377 0.08321329 0.23129288 0.09954593 0.23129288 0.04979722 -1.1392495 0.01535833 0.06270000 0.00670000 -0.05600000 9.564001e-01 2.693666e-11 FALSE TRUE
ENST00000674628 ENSG00000100697 HEK293_OSMI2_2hA HEK293_TMG_2hB DICER1 protein_coding protein_coding 9.721496 3.143914 15.14289 0.3196904 0.308619 2.264377 0.93104242 0.03788562 1.72675077 0.03788562 0.17836071 5.1806543 0.07121667 0.01026667 0.11446667 0.10420000 2.051682e-04 2.693666e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100697 E001 6.1550134 0.0027155912 5.999337e-07 5.226267e-06 14 95086228 95086242 15 - 0.520 1.189 2.646
ENSG00000100697 E002 6.1550134 0.0027155912 5.999337e-07 5.226267e-06 14 95086243 95086243 1 - 0.520 1.189 2.646
ENSG00000100697 E003 51.2792747 0.0178226228 1.786021e-21 1.349646e-19 14 95086244 95086455 212 - 1.293 2.116 2.798
ENSG00000100697 E004 45.3832515 0.0343689845 7.994240e-13 1.994766e-11 14 95086456 95086503 48 - 1.254 2.059 2.743
ENSG00000100697 E005 53.7438501 0.0424730300 1.957799e-09 2.746181e-08 14 95086504 95086573 70 - 1.372 2.100 2.471
ENSG00000100697 E006 154.3744780 0.0095498731 3.515975e-22 2.850196e-20 14 95086574 95087082 509 - 1.907 2.480 1.916
ENSG00000100697 E007 42.4733203 0.0020012354 1.227865e-07 1.226033e-06 14 95087083 95087083 1 - 1.449 1.812 1.238
ENSG00000100697 E008 65.8635311 0.0004187835 9.858543e-15 3.246430e-13 14 95087084 95087148 65 - 1.616 2.021 1.364
ENSG00000100697 E009 59.7611152 0.0004172175 1.448542e-17 6.964185e-16 14 95087149 95087229 81 - 1.550 2.006 1.542
ENSG00000100697 E010 150.4313083 0.0005341298 1.673652e-31 3.111563e-29 14 95087230 95087839 610 - 1.964 2.380 1.392
ENSG00000100697 E011 71.0958983 0.0036063720 2.586582e-04 1.211242e-03 14 95087840 95087898 59 - 1.710 1.952 0.815
ENSG00000100697 E012 220.6530961 0.0020230807 1.736228e-10 2.940489e-09 14 95087899 95088664 766 - 2.189 2.446 0.856
ENSG00000100697 E013 63.0485629 0.0003669160 4.151288e-03 1.356719e-02 14 95088665 95088848 184 - 1.671 1.861 0.641
ENSG00000100697 E014 57.4067054 0.0198937661 4.371872e-01 5.791969e-01 14 95088849 95089008 160 - 1.648 1.769 0.412
ENSG00000100697 E015 62.4316460 0.0232014146 1.232992e-01 2.246760e-01 14 95089009 95089246 238 - 1.665 1.855 0.641
ENSG00000100697 E016 27.0955351 0.0013501494 2.167500e-01 3.464939e-01 14 95089247 95089269 23 - 1.326 1.466 0.485
ENSG00000100697 E017 215.9465345 0.0022384284 3.001051e-01 4.417458e-01 14 95089270 95090320 1051 - 2.246 2.254 0.025
ENSG00000100697 E018 56.1311757 0.0006626491 6.707181e-01 7.770804e-01 14 95090321 95090431 111 - 1.665 1.686 0.069
ENSG00000100697 E019 50.7399882 0.0078732868 4.234147e-01 5.664614e-01 14 95090432 95090491 60 - 1.605 1.704 0.337
ENSG00000100697 E020 38.3345987 0.0065645368 2.273947e-01 3.592871e-01 14 95090492 95090502 11 - 1.478 1.612 0.456
ENSG00000100697 E021 35.8131444 0.0124543295 2.886161e-01 4.292198e-01 14 95090503 95090512 10 - 1.451 1.581 0.448
ENSG00000100697 E022 41.0379980 0.0064559220 1.709924e-01 2.894673e-01 14 95090513 95090536 24 - 1.504 1.647 0.487
ENSG00000100697 E023 78.7325843 0.0003650861 7.923426e-02 1.582906e-01 14 95090537 95090663 127 - 1.785 1.911 0.426
ENSG00000100697 E024 0.8899506 0.0134830799 2.159993e-01 3.455854e-01 14 95090664 95090664 1 - 0.284 0.000 -13.459
ENSG00000100697 E025 2.1852409 0.0063981199 5.862287e-01 7.098343e-01 14 95090665 95091033 369 - 0.455 0.376 -0.425
ENSG00000100697 E026 63.1135360 0.0026803544 5.422931e-01 6.730771e-01 14 95091034 95091109 76 - 1.700 1.780 0.271
ENSG00000100697 E027 101.0581730 0.0041973835 3.951690e-01 5.389979e-01 14 95091203 95091360 158 - 1.900 1.990 0.303
ENSG00000100697 E028 41.4808567 0.0005125037 4.023665e-01 5.460964e-01 14 95091361 95091365 5 - 1.521 1.619 0.335
ENSG00000100697 E029 2.0076892 0.0811099915 2.719521e-01 4.107708e-01 14 95091366 95091422 57 - 0.455 0.228 -1.419
ENSG00000100697 E030 0.5954526 0.0183066850 4.151533e-01 5.585588e-01 14 95092569 95092593 25 - 0.208 0.000 -12.899
ENSG00000100697 E031 0.4439371 0.0215551093 6.095063e-01 7.289995e-01 14 95092594 95092694 101 - 0.165 0.000 -12.495
ENSG00000100697 E032 111.6267709 0.0002803896 7.621900e-02 1.534542e-01 14 95093888 95094156 269 - 1.936 2.051 0.386
ENSG00000100697 E033 0.1515154 0.0428414596 1.000000e+00   14 95095346 95095366 21 - 0.062 0.000 -10.895
ENSG00000100697 E034 1.5531800 0.0387146707 4.489088e-02 1.000052e-01 14 95095367 95095824 458 - 0.248 0.645 2.151
ENSG00000100697 E035 227.2776547 0.0004054912 2.600852e-01 3.975646e-01 14 95095825 95096713 889 - 2.268 2.281 0.042
ENSG00000100697 E036 58.5010313 0.0073074539 8.419165e-02 1.661209e-01 14 95099780 95099906 127 - 1.705 1.627 -0.266
ENSG00000100697 E037 34.6637571 0.0058094687 5.536546e-03 1.738258e-02 14 95099907 95099935 29 - 1.504 1.307 -0.683
ENSG00000100697 E038 106.1641009 0.0022251774 2.145406e-04 1.026443e-03 14 95103346 95103707 362 - 1.970 1.831 -0.468
ENSG00000100697 E039 88.4627383 0.0037178663 3.178889e-05 1.880033e-04 14 95103708 95104049 342 - 1.901 1.704 -0.663
ENSG00000100697 E040 31.8486982 0.0006331026 1.403548e-02 3.830610e-02 14 95104050 95104126 77 - 1.460 1.307 -0.533
ENSG00000100697 E041 56.0004145 0.0004272889 2.544167e-03 8.895335e-03 14 95105071 95105246 176 - 1.697 1.557 -0.477
ENSG00000100697 E042 0.3030308 0.3601182099 1.000000e+00   14 95105247 95105403 157 - 0.117 0.000 -11.226
ENSG00000100697 E043 60.4316231 0.0081014046 6.826204e-04 2.835600e-03 14 95105678 95105783 106 - 1.741 1.532 -0.712
ENSG00000100697 E044 42.8117730 0.0005104281 4.880222e-06 3.483454e-05 14 95106041 95106079 39 - 1.607 1.307 -1.033
ENSG00000100697 E045 61.1410733 0.0010961128 3.971568e-08 4.370109e-07 14 95106080 95106223 144 - 1.760 1.444 -1.076
ENSG00000100697 E046 0.0000000       14 95106224 95106236 13 -      
ENSG00000100697 E047 65.5669215 0.0004013286 1.912829e-08 2.239124e-07 14 95107608 95107761 154 - 1.787 1.485 -1.025
ENSG00000100697 E048 0.0000000       14 95107762 95107773 12 -      
ENSG00000100697 E049 84.3459856 0.0003349877 8.048147e-15 2.685272e-13 14 95107880 95108093 214 - 1.906 1.505 -1.360
ENSG00000100697 E050 75.4436166 0.0005918370 2.568887e-16 1.052255e-14 14 95108324 95108503 180 - 1.865 1.387 -1.627
ENSG00000100697 E051 0.2903454 0.3512909523 1.000000e+00   14 95111307 95111316 10 - 0.116 0.000 -11.226
ENSG00000100697 E052 82.7718524 0.0004172342 1.705143e-16 7.129423e-15 14 95111317 95111456 140 - 1.901 1.455 -1.516
ENSG00000100697 E053 61.4515515 0.0003672092 5.275106e-12 1.149078e-10 14 95112172 95112247 76 - 1.771 1.349 -1.445
ENSG00000100697 E054 72.7778777 0.0003364124 3.225886e-14 9.847477e-13 14 95113092 95113224 133 - 1.843 1.411 -1.471
ENSG00000100697 E055 63.2746910 0.0102703079 5.973332e-07 5.205050e-06 14 95115667 95115821 155 - 1.776 1.403 -1.274
ENSG00000100697 E056 50.1570945 0.0054800949 2.260912e-04 1.075162e-03 14 95116453 95116580 128 - 1.663 1.424 -0.818
ENSG00000100697 E057 52.7081501 0.0011127444 5.477651e-06 3.864320e-05 14 95116581 95116695 115 - 1.689 1.422 -0.912
ENSG00000100697 E058 56.9535460 0.0017769314 2.790375e-08 3.160896e-07 14 95117622 95117754 133 - 1.732 1.387 -1.179
ENSG00000100697 E059 111.2614954 0.0002962205 4.536181e-21 3.297644e-19 14 95124196 95124668 473 - 2.027 1.589 -1.477
ENSG00000100697 E060 58.4567690 0.0097646588 1.134693e-08 1.384722e-07 14 95126580 95126748 169 - 1.752 1.293 -1.574
ENSG00000100697 E061 0.0000000       14 95129061 95129471 411 -      
ENSG00000100697 E062 53.0580102 0.0093789292 8.054603e-10 1.215873e-08 14 95129472 95129632 161 - 1.717 1.190 -1.821
ENSG00000100697 E063 51.5568216 0.0004886688 5.607993e-13 1.432215e-11 14 95130058 95130192 135 - 1.704 1.189 -1.779
ENSG00000100697 E064 0.5954526 0.0183066850 4.151533e-01 5.585588e-01 14 95131245 95131508 264 - 0.208 0.000 -12.899
ENSG00000100697 E065 55.9242730 0.0004154009 4.717271e-15 1.628413e-13 14 95131509 95131639 131 - 1.741 1.189 -1.903
ENSG00000100697 E066 3.1985943 0.0349041658 5.778773e-02 1.228341e-01 14 95131640 95132052 413 - 0.611 0.228 -2.161
ENSG00000100697 E067 4.6093512 0.0036304581 1.845216e-03 6.743653e-03 14 95132053 95132514 462 - 0.520 0.998 1.954
ENSG00000100697 E068 65.6335534 0.0003676716 4.913926e-16 1.932991e-14 14 95132515 95132677 163 - 1.807 1.292 -1.765
ENSG00000100697 E069 62.4191693 0.0023463745 1.747227e-18 9.342563e-17 14 95133315 95133503 189 - 1.796 1.127 -2.310
ENSG00000100697 E070 5.6391335 0.0233589353 2.372925e-03 8.377159e-03 14 95134361 95134503 143 - 0.826 0.227 -3.049
ENSG00000100697 E071 0.1817044 0.0392589562 1.063079e-01   14 95136623 95136810 188 - 0.000 0.227 13.387
ENSG00000100697 E072 21.0615552 0.0078726291 8.282969e-08 8.548614e-07 14 95140659 95140754 96 - 1.341 0.648 -2.603
ENSG00000100697 E073 8.3709510 0.0148212168 6.351163e-04 2.662791e-03 14 95140755 95140759 5 - 0.969 0.376 -2.593
ENSG00000100697 E074 1.0436561 0.0153220885 1.617828e-01 2.774467e-01 14 95141154 95141187 34 - 0.318 0.000 -13.669
ENSG00000100697 E075 12.9914726 0.0026562375 2.418335e-04 1.141058e-03 14 95141683 95141748 66 - 1.129 0.647 -1.858
ENSG00000100697 E076 0.1451727 0.0434488414 1.000000e+00   14 95146565 95146617 53 - 0.062 0.000 -10.892
ENSG00000100697 E077 0.9525186 0.0149655881 4.469553e-01 5.883936e-01 14 95156187 95156403 217 - 0.208 0.376 1.160
ENSG00000100697 E078 19.5401741 0.0132422648 2.286557e-05 1.398352e-04 14 95157230 95157390 161 - 1.300 0.765 -1.974
ENSG00000100697 E079 4.1278078 0.0078992671 9.006397e-04 3.616053e-03 14 95157391 95157529 139 - 0.725 0.000 -15.467
ENSG00000100697 E080 0.2987644 0.0272264146 1.000000e+00   14 95157931 95158010 80 - 0.117 0.000 -11.916