ENSG00000100629

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000216517 ENSG00000100629 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP128 protein_coding protein_coding 4.558588 2.355271 6.168673 0.09293179 0.1412434 1.385291 0.1198987 0.0000000 0.3821797 0.00000000 0.38217968 5.2934429 0.0211875 0.00000000 0.0609000 0.06090000 9.803477e-01 4.963729e-05 FALSE TRUE
ENST00000281129 ENSG00000100629 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP128 protein_coding protein_coding 4.558588 2.355271 6.168673 0.09293179 0.1412434 1.385291 0.1105996 0.3746157 0.0000000 0.37461573 0.00000000 -5.2653459 0.0397125 0.14893333 0.0000000 -0.14893333 6.655760e-01 4.963729e-05 FALSE TRUE
ENST00000554502 ENSG00000100629 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP128 protein_coding nonsense_mediated_decay 4.558588 2.355271 6.168673 0.09293179 0.1412434 1.385291 0.5673517 0.4285168 0.5765113 0.03908720 0.04132448 0.4195268 0.1540167 0.18140000 0.0938000 -0.08760000 6.105587e-02 4.963729e-05 TRUE TRUE
ENST00000555265 ENSG00000100629 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP128 protein_coding protein_coding 4.558588 2.355271 6.168673 0.09293179 0.1412434 1.385291 2.4663951 1.0968048 2.9873798 0.31162801 0.31180943 1.4373011 0.5389458 0.47533333 0.4863000 0.01096667 9.965598e-01 4.963729e-05 FALSE TRUE
MSTRG.10021.2 ENSG00000100629 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP128 protein_coding   4.558588 2.355271 6.168673 0.09293179 0.1412434 1.385291 0.9051051 0.2122250 1.8606660 0.05841098 0.15768166 3.0734590 0.1623750 0.08856667 0.3007667 0.21220000 4.963729e-05 4.963729e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100629 E001 23.6762069 0.0008232461 8.590830e-07 7.237546e-06 14 80476983 80478177 1195 - 1.210 1.569 1.244
ENSG00000100629 E002 8.6691351 0.0019807871 1.788807e-02 4.689788e-02 14 80478178 80478407 230 - 0.856 1.126 1.002
ENSG00000100629 E003 0.4407149 0.0214776096 8.684985e-01 9.194634e-01 14 80490479 80490722 244 - 0.150 0.180 0.322
ENSG00000100629 E004 0.2966881 0.0290785164 5.750233e-01   14 80496474 80496478 5 - 0.150 0.000 -11.088
ENSG00000100629 E005 59.7039913 0.0139831073 1.004783e-05 6.673439e-05 14 80496479 80497468 990 - 1.627 1.944 1.070
ENSG00000100629 E006 17.9096035 0.0020028622 1.193976e-01 2.190837e-01 14 80497469 80497496 28 - 1.204 1.344 0.491
ENSG00000100629 E007 26.3250150 0.0039248435 2.545894e-02 6.282312e-02 14 80497497 80497582 86 - 1.350 1.523 0.598
ENSG00000100629 E008 26.1526982 0.0096488949 2.224636e-02 5.618504e-02 14 80504912 80505020 109 - 1.338 1.535 0.680
ENSG00000100629 E009 0.6255398 0.0190409305 6.119303e-02 1.286321e-01 14 80526684 80526868 185 - 0.081 0.405 2.906
ENSG00000100629 E010 26.4797101 0.0007215337 1.191287e-02 3.332531e-02 14 80526869 80526982 114 - 1.342 1.524 0.629
ENSG00000100629 E011 0.4482035 0.0276739407 3.342434e-01 4.779840e-01 14 80527169 80527261 93 - 0.209 0.000 -11.673
ENSG00000100629 E012 23.6853707 0.0011162331 3.736600e-01 5.180691e-01 14 80530809 80530886 78 - 1.334 1.410 0.266
ENSG00000100629 E013 0.0000000       14 80530887 80531000 114 -      
ENSG00000100629 E014 17.3898968 0.0010576097 6.262508e-01 7.422274e-01 14 80559279 80559302 24 - 1.216 1.267 0.183
ENSG00000100629 E015 16.0131597 0.0010921786 2.003649e-01 3.266767e-01 14 80580374 80580423 50 - 1.157 1.279 0.431
ENSG00000100629 E016 0.0000000       14 80580424 80580425 2 -      
ENSG00000100629 E017 0.2934659 0.0294028843 5.143316e-01   14 80742755 80743074 320 - 0.081 0.180 1.322
ENSG00000100629 E018 33.0073134 0.0006537451 1.153972e-02 3.244148e-02 14 80743075 80743267 193 - 1.443 1.609 0.569
ENSG00000100629 E019 19.0449065 0.0011461532 1.611433e-01 2.765980e-01 14 80756892 80756951 60 - 1.231 1.355 0.431
ENSG00000100629 E020 31.7743302 0.0007033571 3.842307e-02 8.814434e-02 14 80761437 80761613 177 - 1.433 1.575 0.486
ENSG00000100629 E021 32.3687426 0.0006786154 3.027821e-01 4.446981e-01 14 80777882 80778046 165 - 1.468 1.544 0.260
ENSG00000100629 E022 68.3465430 0.0005039081 2.207803e-01 3.513653e-01 14 80784895 80785545 651 - 1.825 1.780 -0.152
ENSG00000100629 E023 50.2402758 0.0005314320 9.910450e-04 3.927670e-03 14 80792760 80793110 351 - 1.728 1.557 -0.582
ENSG00000100629 E024 1.2564668 0.0143291742 6.142743e-01 7.327940e-01 14 80830165 80830283 119 - 0.307 0.405 0.586
ENSG00000100629 E025 6.3409751 0.0025968491 2.574075e-02 6.340693e-02 14 80830284 80831142 859 - 0.726 1.012 1.102
ENSG00000100629 E026 36.5338342 0.0106060711 2.438590e-02 6.061394e-02 14 80831143 80831294 152 - 1.592 1.421 -0.584
ENSG00000100629 E027 32.9297072 0.0009077284 4.995576e-01 6.358698e-01 14 80836205 80836337 133 - 1.509 1.475 -0.116
ENSG00000100629 E028 26.8573895 0.0007959492 3.360848e-01 4.799072e-01 14 80838204 80838278 75 - 1.433 1.374 -0.205
ENSG00000100629 E029 26.3902476 0.0022673137 1.432432e-01 2.524395e-01 14 80840682 80840768 87 - 1.436 1.335 -0.352
ENSG00000100629 E030 27.7158014 0.0007312288 4.902957e-01 6.276356e-01 14 80862757 80862873 117 - 1.440 1.402 -0.132
ENSG00000100629 E031 19.0714972 0.0009577717 2.436952e-02 6.058148e-02 14 80895718 80895790 73 - 1.330 1.142 -0.661
ENSG00000100629 E032 12.1194468 0.0014387572 7.607057e-02 1.532241e-01 14 80899938 80899972 35 - 1.145 0.966 -0.654
ENSG00000100629 E033 13.4929762 0.0038073106 9.383335e-03 2.724113e-02 14 80899973 80900029 57 - 1.210 0.940 -0.980
ENSG00000100629 E034 23.1892014 0.0008286006 3.050651e-04 1.400074e-03 14 80904813 80904909 97 - 1.433 1.142 -1.021
ENSG00000100629 E035 15.3973845 0.0011563851 5.434308e-03 1.711008e-02 14 80904910 80904931 22 - 1.257 0.989 -0.963
ENSG00000100629 E036 0.0000000       14 80905471 80905954 484 -      
ENSG00000100629 E037 22.7212653 0.0008986067 6.224985e-04 2.615156e-03 14 80905955 80906081 127 - 1.420 1.142 -0.974
ENSG00000100629 E038 0.1482932 0.0418787528 1.973861e-01   14 80914316 80914321 6 - 0.000 0.180 12.449
ENSG00000100629 E039 20.2854028 0.0009702451 3.260323e-02 7.700709e-02 14 80914322 80914408 87 - 1.346 1.173 -0.607
ENSG00000100629 E040 18.6567920 0.0010216725 2.427027e-02 6.036982e-02 14 80916401 80916451 51 - 1.317 1.126 -0.675
ENSG00000100629 E041 21.4538551 0.0008895344 5.253667e-02 1.136799e-01 14 80916452 80916540 89 - 1.366 1.216 -0.524
ENSG00000100629 E042 12.2571414 0.0014204873 4.605615e-01 6.005741e-01 14 80916541 80916562 22 - 1.118 1.053 -0.237
ENSG00000100629 E043 29.4339685 0.0053963831 4.880487e-02 1.070342e-01 14 80939385 80939540 156 - 1.497 1.355 -0.493
ENSG00000100629 E044 17.8873917 0.0010846396 2.835113e-03 9.779388e-03 14 80941581 80941745 165 - 1.321 1.053 -0.954
ENSG00000100629 E045 0.0000000       14 80942284 80942380 97 -      
ENSG00000100629 E046 0.0000000       14 80945556 80945767 212 -      
ENSG00000100629 E047 0.0000000       14 80957798 80958177 380 -      
ENSG00000100629 E048 0.1451727 0.0428110905 1.000000e+00   14 80958178 80958285 108 - 0.081 0.000 -10.088
ENSG00000100629 E049 0.0000000       14 80959432 80959517 86 -