ENSG00000100612

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000536410 ENSG00000100612 HEK293_OSMI2_2hA HEK293_TMG_2hB DHRS7 protein_coding protein_coding 53.18784 35.86788 76.80354 4.338625 1.710404 1.098266 30.985274 23.495682 44.821910 3.0723024 0.6961409 0.9315164 0.58716667 0.6534333 0.5837667 -0.06966667 3.096221e-02 1.131842e-23 FALSE  
ENST00000555171 ENSG00000100612 HEK293_OSMI2_2hA HEK293_TMG_2hB DHRS7 protein_coding retained_intron 53.18784 35.86788 76.80354 4.338625 1.710404 1.098266 4.170274 0.000000 5.389622 0.0000000 0.5932069 9.0767145 0.08167083 0.0000000 0.0705000 0.07050000 1.131842e-23 1.131842e-23 FALSE  
ENST00000556502 ENSG00000100612 HEK293_OSMI2_2hA HEK293_TMG_2hB DHRS7 protein_coding retained_intron 53.18784 35.86788 76.80354 4.338625 1.710404 1.098266 4.287159 4.416466 5.648386 0.3667743 0.7937620 0.3542352 0.07976250 0.1253667 0.0738000 -0.05156667 1.053025e-01 1.131842e-23 FALSE  
ENST00000557137 ENSG00000100612 HEK293_OSMI2_2hA HEK293_TMG_2hB DHRS7 protein_coding protein_coding 53.18784 35.86788 76.80354 4.338625 1.710404 1.098266 10.667719 5.317512 17.276040 0.6499656 1.9550118 1.6980736 0.18839167 0.1491000 0.2245000 0.07540000 8.837780e-02 1.131842e-23 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100612 E001 0.2924217 0.0294853465 3.647448e-01   14 60144119 60144119 1 - 0.182 0.000 -10.026
ENSG00000100612 E002 9.3375365 0.0162700580 1.908199e-01 0.3147743605 14 60144120 60144805 686 - 0.945 1.104 0.587
ENSG00000100612 E003 246.3384313 0.0002142755 1.616384e-02 0.0430875721 14 60144806 60145013 208 - 2.369 2.424 0.182
ENSG00000100612 E004 8.4167406 0.0977637957 3.679391e-02 0.0850755512 14 60148948 60149352 405 - 0.795 1.129 1.253
ENSG00000100612 E005 351.9410247 0.0004953431 4.415303e-01 0.5831712323 14 60149353 60149449 97 - 2.542 2.557 0.050
ENSG00000100612 E006 208.9819597 0.0003371763 2.487380e-01 0.3844363656 14 60149450 60149458 9 - 2.336 2.308 -0.096
ENSG00000100612 E007 398.3401897 0.0002033521 1.996662e-01 0.3258151507 14 60149459 60149568 110 - 2.593 2.616 0.076
ENSG00000100612 E008 252.9574587 0.0002118316 5.915138e-01 0.7142791070 14 60150065 60150099 35 - 2.401 2.414 0.041
ENSG00000100612 E009 224.6826603 0.0002689115 2.082243e-01 0.3363587062 14 60150100 60150117 18 - 2.342 2.372 0.101
ENSG00000100612 E010 282.0712080 0.0008645320 6.931278e-01 0.7942026968 14 60150118 60150187 70 - 2.449 2.457 0.026
ENSG00000100612 E011 6.2920627 0.0028067167 4.550834e-01 0.5956445825 14 60152689 60152938 250 - 0.828 0.920 0.356
ENSG00000100612 E012 455.2697123 0.0001373361 9.671771e-01 0.9834197468 14 60152939 60153178 240 - 2.661 2.662 0.004
ENSG00000100612 E013 266.5823545 0.0002237539 1.418977e-01 0.2506371583 14 60153959 60154065 107 - 2.416 2.449 0.109
ENSG00000100612 E014 0.2944980 0.3550460119 4.670963e-01   14 60155832 60155999 168 - 0.182 0.000 -10.024
ENSG00000100612 E015 272.3853864 0.0016964473 1.851924e-01 0.3077272827 14 60156000 60156102 103 - 2.453 2.417 -0.122
ENSG00000100612 E016 225.7836810 0.0002056898 6.121004e-03 0.0189254015 14 60156103 60156152 50 - 2.384 2.318 -0.218
ENSG00000100612 E017 217.4370950 0.0002510348 1.884963e-05 0.0001176259 14 60165177 60165308 132 - 2.381 2.275 -0.356
ENSG00000100612 E018 88.2166594 0.0033629508 6.813055e-01 0.7850224208 14 60165309 60165599 291 - 1.959 1.934 -0.084
ENSG00000100612 E019 0.0000000       14 60165600 60165605 6 -      
ENSG00000100612 E020 0.0000000       14 60166203 60166305 103 -      
ENSG00000100612 E021 0.1515154 0.0432031500 7.641239e-01   14 60169697 60169856 160 - 0.100 0.000 -9.025