ENSG00000100605

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000553695 ENSG00000100605 HEK293_OSMI2_2hA HEK293_TMG_2hB ITPK1 protein_coding processed_transcript 45.66037 70.79855 31.55847 6.235199 2.197333 -1.165439 3.829879 0.0000000 4.567638 0.0000000 2.3356448 8.8384597 0.11515833 0.000000000 0.1383 0.138300000 1.169849e-01 1.731668e-06 FALSE FALSE
ENST00000555495 ENSG00000100605 HEK293_OSMI2_2hA HEK293_TMG_2hB ITPK1 protein_coding protein_coding 45.66037 70.79855 31.55847 6.235199 2.197333 -1.165439 19.730622 33.1991593 11.436435 2.9040309 0.4284986 -1.5366829 0.41275000 0.469100000 0.3670 -0.102100000 1.435520e-01 1.731668e-06 FALSE TRUE
ENST00000555553 ENSG00000100605 HEK293_OSMI2_2hA HEK293_TMG_2hB ITPK1 protein_coding protein_coding 45.66037 70.79855 31.55847 6.235199 2.197333 -1.165439 3.276109 3.9700405 2.056012 1.1909609 1.3943700 -0.9459347 0.07327083 0.053933333 0.0617 0.007766667 8.966454e-01 1.731668e-06 FALSE FALSE
ENST00000556603 ENSG00000100605 HEK293_OSMI2_2hA HEK293_TMG_2hB ITPK1 protein_coding protein_coding 45.66037 70.79855 31.55847 6.235199 2.197333 -1.165439 14.696332 29.0581746 6.658702 1.4006893 0.2360252 -2.1239625 0.29503333 0.414600000 0.2124 -0.202200000 1.731668e-06 1.731668e-06 FALSE TRUE
MSTRG.10106.6 ENSG00000100605 HEK293_OSMI2_2hA HEK293_TMG_2hB ITPK1 protein_coding   45.66037 70.79855 31.55847 6.235199 2.197333 -1.165439 1.167467 0.6748796 2.822634 0.2906138 0.5725947 2.0482217 0.03324167 0.008966667 0.0904 0.081433333 1.999882e-03 1.731668e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100605 E001 29.4414484 0.0012333466 6.469951e-01 7.587767e-01 14 92936914 92938526 1613 - 1.401 1.412 0.037
ENSG00000100605 E002 8.4367820 0.0030261635 6.065925e-01 7.266843e-01 14 92938527 92939752 1226 - 0.931 0.908 -0.087
ENSG00000100605 E003 58.3489489 0.0031154994 7.206914e-05 3.902387e-04 14 92939753 92939861 109 - 1.445 1.757 1.061
ENSG00000100605 E004 1646.4083909 0.0058220515 5.899486e-10 9.132537e-09 14 92939862 92940890 1029 - 2.936 3.190 0.845
ENSG00000100605 E005 1261.4390984 0.0011880339 9.682362e-04 3.849920e-03 14 92940891 92941904 1014 - 2.939 3.050 0.369
ENSG00000100605 E006 439.6774542 0.0009786588 1.502759e-01 2.620567e-01 14 92946331 92946458 128 - 2.557 2.571 0.048
ENSG00000100605 E007 305.8258960 0.0002447832 1.270691e-01 2.300542e-01 14 92946459 92946493 35 - 2.401 2.411 0.033
ENSG00000100605 E008 410.8004116 0.0001429883 3.785286e-05 2.194879e-04 14 92951946 92952013 68 - 2.564 2.527 -0.121
ENSG00000100605 E009 329.2632943 0.0001839440 1.464127e-07 1.440412e-06 14 92958201 92958233 33 - 2.495 2.424 -0.236
ENSG00000100605 E010 313.8225092 0.0001470508 6.935302e-05 3.768829e-04 14 92958234 92958270 37 - 2.453 2.408 -0.149
ENSG00000100605 E011 403.8609921 0.0008004332 2.656420e-05 1.600263e-04 14 92958271 92958366 96 - 2.567 2.517 -0.167
ENSG00000100605 E012 275.4532327 0.0004373500 1.624060e-01 2.782737e-01 14 92962355 92962395 41 - 2.355 2.365 0.034
ENSG00000100605 E013 334.3320139 0.0005882116 8.694542e-05 4.607426e-04 14 92962751 92962831 81 - 2.482 2.435 -0.159
ENSG00000100605 E014 213.8143332 0.0002079106 6.448024e-04 2.697341e-03 14 92962832 92962849 18 - 2.289 2.240 -0.163
ENSG00000100605 E015 0.6997360 0.0167930756 2.829643e-01 4.230329e-01 14 92962850 92962867 18 - 0.001 0.252 9.393
ENSG00000100605 E016 363.0227378 0.0010363783 1.730771e-02 4.561834e-02 14 92993880 92993997 118 - 2.492 2.480 -0.040
ENSG00000100605 E017 0.0000000       14 92998903 92998939 37 -      
ENSG00000100605 E018 323.1725396 0.0029724619 5.869831e-02 1.244012e-01 14 93016676 93016801 126 - 2.443 2.431 -0.040
ENSG00000100605 E019 0.0000000       14 93036847 93036974 128 -      
ENSG00000100605 E020 0.2955422 0.0291329160 4.176024e-01   14 93066185 93066358 174 - 0.187 0.078 -1.452
ENSG00000100605 E021 143.1480479 0.0027243767 3.197902e-01 4.628777e-01 14 93076595 93076619 25 - 2.073 2.081 0.026
ENSG00000100605 E022 218.1814947 0.0038282770 3.434409e-03 1.153676e-02 14 93115069 93115184 116 - 2.311 2.247 -0.214
ENSG00000100605 E023 105.2394192 0.0054970142 1.639592e-03 6.088239e-03 14 93115185 93115217 33 - 2.031 1.919 -0.377
ENSG00000100605 E024 88.5362496 0.0101130815 3.098126e-03 1.055460e-02 14 93115218 93115305 88 - 1.975 1.839 -0.458
ENSG00000100605 E025 21.9760053 0.0467115237 2.953227e-05 1.760413e-04 14 93115772 93115925 154 - 1.592 1.129 -1.614
ENSG00000100605 E026 9.6819842 0.0017515307 7.218558e-02 1.469759e-01 14 93116076 93116320 245 - 1.070 0.908 -0.600