ENSG00000100603

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261531 ENSG00000100603 HEK293_OSMI2_2hA HEK293_TMG_2hB SNW1 protein_coding protein_coding 48.63698 34.21699 66.93262 2.458713 0.7850732 0.9677907 43.439837 24.043315 63.05217 0.6627527 2.173965 1.390539 0.86546667 0.7080667 0.9416667 0.2336000 1.437224e-03 1.280156e-38 FALSE TRUE
ENST00000554775 ENSG00000100603 HEK293_OSMI2_2hA HEK293_TMG_2hB SNW1 protein_coding protein_coding 48.63698 34.21699 66.93262 2.458713 0.7850732 0.9677907 3.072682 9.419746 0.00000 1.9895336 0.000000 -9.881075 0.09147083 0.2702333 0.0000000 -0.2702333 1.280156e-38 1.280156e-38 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100603 E001 3.0675338 0.0214128072 2.010038e-03 7.257259e-03 14 77717599 77717627 29 - 0.340 0.857 2.381
ENSG00000100603 E002 241.8059528 0.0034892326 8.889575e-19 4.944519e-17 14 77717628 77717790 163 - 2.209 2.553 1.148
ENSG00000100603 E003 433.3411343 0.0046993023 2.638161e-08 3.004459e-07 14 77717791 77717952 162 - 2.527 2.751 0.744
ENSG00000100603 E004 750.7262109 0.0011625579 3.280739e-07 3.011124e-06 14 77717953 77718286 334 - 2.816 2.938 0.407
ENSG00000100603 E005 12.6799406 0.0076496431 2.975954e-01 4.389554e-01 14 77718287 77718366 80 - 1.077 1.207 0.465
ENSG00000100603 E006 550.8914433 0.0001289682 1.738832e-05 1.093535e-04 14 77718367 77718530 164 - 2.697 2.787 0.300
ENSG00000100603 E007 431.3193500 0.0001347926 2.045980e-01 3.319132e-01 14 77720711 77720828 118 - 2.609 2.655 0.154
ENSG00000100603 E008 386.9072919 0.0001435960 1.586653e-01 2.733551e-01 14 77723181 77723277 97 - 2.581 2.578 -0.008
ENSG00000100603 E009 0.4417471 0.6983974486 5.045852e-01 6.404963e-01 14 77730856 77730987 132 - 0.233 0.000 -9.813
ENSG00000100603 E010 437.9794376 0.0001305225 1.406679e-03 5.328543e-03 14 77730988 77731129 142 - 2.646 2.614 -0.107
ENSG00000100603 E011 278.1931741 0.0001589820 9.486996e-03 2.750410e-02 14 77732485 77732538 54 - 2.450 2.416 -0.112
ENSG00000100603 E012 280.8586049 0.0002148146 2.679718e-02 6.557025e-02 14 77732539 77732601 63 - 2.451 2.426 -0.085
ENSG00000100603 E013 250.6136183 0.0002168003 1.223577e-01 2.233106e-01 14 77734947 77735012 66 - 2.396 2.384 -0.041
ENSG00000100603 E014 225.5580952 0.0025074561 4.509715e-02 1.003767e-01 14 77735937 77736006 70 - 2.363 2.315 -0.162
ENSG00000100603 E015 212.7467133 0.0022409272 1.137960e-02 3.207223e-02 14 77736971 77737075 105 - 2.345 2.279 -0.218
ENSG00000100603 E016 0.7363589 0.0154780973 7.064415e-02 1.444098e-01 14 77738738 77738777 40 - 0.340 0.000 -10.553
ENSG00000100603 E017 207.8681583 0.0004920032 1.196147e-03 4.627360e-03 14 77738778 77738884 107 - 2.336 2.272 -0.214
ENSG00000100603 E018 233.9204952 0.0011527457 3.192715e-04 1.457997e-03 14 77738966 77739061 96 - 2.392 2.310 -0.273
ENSG00000100603 E019 363.8789288 0.0002313983 4.075149e-11 7.671152e-10 14 77751319 77751480 162 - 2.594 2.484 -0.364
ENSG00000100603 E020 314.3562264 0.0001725093 1.470421e-14 4.731094e-13 14 77754967 77755098 132 - 2.540 2.399 -0.470
ENSG00000100603 E021 163.9637405 0.0002434406 2.015285e-10 3.375086e-09 14 77755099 77755120 22 - 2.265 2.099 -0.555
ENSG00000100603 E022 138.3395669 0.0002431818 1.377983e-09 1.990808e-08 14 77761114 77761207 94 - 2.194 2.022 -0.577