ENSG00000100592

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360909 ENSG00000100592 HEK293_OSMI2_2hA HEK293_TMG_2hB DAAM1 protein_coding protein_coding 6.042368 2.098352 9.755833 0.3488731 1.249448 2.211627 2.7639615 0.4361084 4.22583940 0.21824938 0.35493586 3.2471817 0.41165000 0.22450000 0.4456333 0.22113333 5.203871e-01 7.544168e-26 FALSE TRUE
ENST00000553307 ENSG00000100592 HEK293_OSMI2_2hA HEK293_TMG_2hB DAAM1 protein_coding retained_intron 6.042368 2.098352 9.755833 0.3488731 1.249448 2.211627 0.4643388 0.9525774 0.00000000 0.09099329 0.00000000 -6.5888307 0.19806667 0.46873333 0.0000000 -0.46873333 7.544168e-26 7.544168e-26 FALSE TRUE
ENST00000553472 ENSG00000100592 HEK293_OSMI2_2hA HEK293_TMG_2hB DAAM1 protein_coding retained_intron 6.042368 2.098352 9.755833 0.3488731 1.249448 2.211627 0.1469801 0.1390409 0.09790769 0.13904093 0.09790769 -0.4659109 0.02857500 0.06653333 0.0100000 -0.05653333 8.105070e-01 7.544168e-26 FALSE FALSE
ENST00000554459 ENSG00000100592 HEK293_OSMI2_2hA HEK293_TMG_2hB DAAM1 protein_coding processed_transcript 6.042368 2.098352 9.755833 0.3488731 1.249448 2.211627 1.6864027 0.2590345 2.66505308 0.25903452 0.25065873 3.3137043 0.22561667 0.09570000 0.2770667 0.18136667 2.141433e-01 7.544168e-26 FALSE FALSE
ENST00000557029 ENSG00000100592 HEK293_OSMI2_2hA HEK293_TMG_2hB DAAM1 protein_coding processed_transcript 6.042368 2.098352 9.755833 0.3488731 1.249448 2.211627 0.4323932 0.0000000 1.60136053 0.00000000 0.84250963 7.3321355 0.03966667 0.00000000 0.1463000 0.14630000 3.499990e-01 7.544168e-26 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100592 E001 0.1451727 0.0427354701 1.000000e+00   14 59188646 59188666 21 + 0.058 0.000 -8.338
ENSG00000100592 E002 0.4375944 0.0248410050 7.169504e-01 8.124618e-01 14 59188667 59188679 13 + 0.154 0.000 -12.032
ENSG00000100592 E003 3.2401610 0.0446053921 9.915042e-03 2.855237e-02 14 59188680 59188698 19 + 0.614 0.000 -14.424
ENSG00000100592 E004 9.0918827 0.0019874116 4.409961e-05 2.518172e-04 14 59188699 59188768 70 + 0.978 0.243 -3.506
ENSG00000100592 E005 1.9679483 0.0828074327 3.410601e-01 4.849841e-01 14 59188769 59188914 146 + 0.432 0.243 -1.185
ENSG00000100592 E006 9.5122978 0.0025528836 2.630404e-05 1.586155e-04 14 59263441 59263454 14 + 0.997 0.243 -3.576
ENSG00000100592 E007 32.3553856 0.0102292892 6.323218e-06 4.399569e-05 14 59263455 59263660 206 + 1.473 1.031 -1.560
ENSG00000100592 E008 0.1817044 0.0396912653 8.856260e-02   14 59263661 59266161 2501 + 0.000 0.243 12.893
ENSG00000100592 E009 22.1458045 0.0008771622 2.796787e-04 1.297172e-03 14 59291217 59291306 90 + 1.307 0.965 -1.227
ENSG00000100592 E010 0.0000000       14 59291307 59291508 202 +      
ENSG00000100592 E011 0.0000000       14 59299715 59300015 301 +      
ENSG00000100592 E012 18.4502820 0.0010160021 7.250246e-04 2.989070e-03 14 59315280 59315351 72 + 1.234 0.888 -1.262
ENSG00000100592 E013 18.9279205 0.0010259854 3.627137e-03 1.208814e-02 14 59320490 59320584 95 + 1.238 0.965 -0.985
ENSG00000100592 E014 29.4367389 0.0006829395 3.240458e-03 1.097358e-02 14 59322892 59323225 334 + 1.409 1.203 -0.720
ENSG00000100592 E015 17.2175546 0.0017726118 1.917028e-01 3.158979e-01 14 59324128 59324238 111 + 1.172 1.087 -0.306
ENSG00000100592 E016 0.0000000       14 59324350 59324350 1 +      
ENSG00000100592 E017 8.7540872 0.0019579822 9.512725e-01 9.735339e-01 14 59324351 59324353 3 + 0.884 0.928 0.168
ENSG00000100592 E018 18.0474565 0.0061593750 1.160944e-02 3.260407e-02 14 59324354 59324454 101 + 1.212 0.966 -0.892
ENSG00000100592 E019 18.8393633 0.0010256750 1.802436e-03 6.606933e-03 14 59325664 59325730 67 + 1.234 0.928 -1.110
ENSG00000100592 E020 29.7344672 0.0006863243 5.903083e-02 1.249772e-01 14 59325960 59326077 118 + 1.397 1.295 -0.356
ENSG00000100592 E021 0.0000000       14 59326078 59326115 38 +      
ENSG00000100592 E022 30.9558298 0.0007727194 4.642518e-02 1.028019e-01 14 59326510 59326648 139 + 1.418 1.311 -0.375
ENSG00000100592 E023 22.2504661 0.0057840574 1.278209e-01 2.311412e-01 14 59326933 59326991 59 + 1.282 1.182 -0.352
ENSG00000100592 E024 28.8795778 0.0007971263 1.770562e-01 2.974098e-01 14 59330501 59330688 188 + 1.382 1.326 -0.193
ENSG00000100592 E025 17.3093540 0.0011151405 4.961832e-01 6.329057e-01 14 59331209 59331429 221 + 1.138 1.260 0.432
ENSG00000100592 E026 16.5702685 0.0010964223 1.684617e-01 2.861651e-01 14 59331430 59331508 79 + 1.156 1.060 -0.346
ENSG00000100592 E027 23.9000175 0.0008064844 2.709884e-02 6.619381e-02 14 59331813 59331920 108 + 1.316 1.160 -0.548
ENSG00000100592 E028 0.0000000       14 59338385 59338414 30 +      
ENSG00000100592 E029 28.1369652 0.0007270452 8.102621e-02 1.611465e-01 14 59340074 59340180 107 + 1.371 1.278 -0.327
ENSG00000100592 E030 16.7444080 0.0140939066 9.814277e-01 9.924287e-01 14 59347539 59347546 8 + 1.129 1.185 0.197
ENSG00000100592 E031 30.0598716 0.0007227720 2.643033e-01 4.022739e-01 14 59347547 59347623 77 + 1.389 1.356 -0.116
ENSG00000100592 E032 31.8277162 0.0007223750 2.537745e-01 3.903701e-01 14 59352526 59352632 107 + 1.416 1.384 -0.113
ENSG00000100592 E033 24.1160480 0.0049034513 8.377642e-01 8.985812e-01 14 59353876 59353939 64 + 1.288 1.326 0.133
ENSG00000100592 E034 18.7782844 0.0040357828 9.600103e-01 9.788856e-01 14 59353940 59353964 25 + 1.181 1.242 0.217
ENSG00000100592 E035 0.1482932 0.0416843591 8.906709e-02   14 59355161 59355164 4 + 0.000 0.242 12.873
ENSG00000100592 E036 23.1391114 0.0012614991 3.806651e-01 5.249430e-01 14 59355165 59355232 68 + 1.252 1.383 0.460
ENSG00000100592 E037 27.0239301 0.0009158072 7.780645e-01 8.572262e-01 14 59355233 59355333 101 + 1.336 1.370 0.118
ENSG00000100592 E038 0.1451727 0.0427354701 1.000000e+00   14 59357301 59357330 30 + 0.058 0.000 -10.474
ENSG00000100592 E039 0.8189741 0.0239615408 9.052689e-01 9.436792e-01 14 59359255 59359396 142 + 0.195 0.243 0.403
ENSG00000100592 E040 27.7656126 0.0014263092 7.988243e-01 8.716341e-01 14 59359397 59359504 108 + 1.347 1.384 0.126
ENSG00000100592 E041 0.3268771 0.0287656131 2.669734e-01   14 59360642 59360801 160 + 0.058 0.243 2.402
ENSG00000100592 E042 25.7943545 0.0190659905 8.812682e-01 9.278964e-01 14 59360802 59360862 61 + 1.310 1.383 0.255
ENSG00000100592 E043 2.7669889 0.0368443504 9.040713e-01 9.429497e-01 14 59362261 59363650 1390 + 0.495 0.511 0.081
ENSG00000100592 E044 36.4508208 0.0136393020 9.971825e-01 1.000000e+00 14 59363651 59363782 132 + 1.454 1.514 0.205
ENSG00000100592 E045 39.5764709 0.0007412626 4.465587e-01 5.880499e-01 14 59367429 59367599 171 + 1.475 1.585 0.373
ENSG00000100592 E046 202.8722767 0.0065206971 4.798262e-21 3.477491e-19 14 59368650 59371405 2756 + 2.087 2.501 1.383