ENSG00000100575

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000395159 ENSG00000100575 HEK293_OSMI2_2hA HEK293_TMG_2hB TIMM9 protein_coding protein_coding 43.40474 46.46587 51.53314 2.143217 0.9320459 0.1492984 14.884149 14.353575 19.449641 1.1032891 1.5111824 0.4380702 0.3337833 0.3097333 0.37750000 0.06776667 4.209713e-01 1.541084e-08   FALSE
ENST00000555404 ENSG00000100575 HEK293_OSMI2_2hA HEK293_TMG_2hB TIMM9 protein_coding protein_coding 43.40474 46.46587 51.53314 2.143217 0.9320459 0.1492984 8.360743 8.294764 11.745567 0.3738817 0.3758112 0.5013330 0.1883875 0.1792667 0.22776667 0.04850000 7.417860e-02 1.541084e-08   FALSE
ENST00000555593 ENSG00000100575 HEK293_OSMI2_2hA HEK293_TMG_2hB TIMM9 protein_coding protein_coding 43.40474 46.46587 51.53314 2.143217 0.9320459 0.1492984 4.934856 8.236731 2.469569 1.2597501 0.1863712 -1.7337330 0.1142083 0.1763000 0.04806667 -0.12823333 1.541084e-08 1.541084e-08   FALSE
ENST00000556007 ENSG00000100575 HEK293_OSMI2_2hA HEK293_TMG_2hB TIMM9 protein_coding protein_coding 43.40474 46.46587 51.53314 2.143217 0.9320459 0.1492984 7.001171 7.404706 10.107956 0.8731953 1.2247475 0.4484565 0.1625708 0.1613333 0.19553333 0.03420000 6.717657e-01 1.541084e-08   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100575 E001 0.147249 0.0442813113 4.580018e-01   14 58388598 58388656 59 - 0.127 0.000 -8.843
ENSG00000100575 E002 11.794236 0.0214031330 8.974681e-03 2.621729e-02 14 58399241 58399322 82 - 1.255 0.955 -1.083
ENSG00000100575 E003 13.188699 0.0014380216 1.453983e-02 3.945580e-02 14 58402641 58402755 115 - 1.263 1.040 -0.798
ENSG00000100575 E004 5.078674 0.0502402182 2.109323e-01 3.396383e-01 14 58408388 58408414 27 - 0.893 0.674 -0.871
ENSG00000100575 E005 4.552094 0.0036619367 3.358777e-01 4.797056e-01 14 58408495 58408525 31 - 0.809 0.676 -0.540
ENSG00000100575 E006 8.275647 0.0025572675 7.757004e-01 8.555134e-01 14 58408526 58408602 77 - 0.978 0.944 -0.125
ENSG00000100575 E007 8.479009 0.0020753783 7.653641e-01 8.481576e-01 14 58408603 58408647 45 - 0.993 0.959 -0.126
ENSG00000100575 E008 9.832511 0.0289691247 5.343200e-01 6.663814e-01 14 58408648 58408663 16 - 0.993 1.063 0.257
ENSG00000100575 E009 155.082265 0.0002363538 3.202438e-04 1.461874e-03 14 58408664 58408811 148 - 2.130 2.232 0.342
ENSG00000100575 E010 222.750681 0.0002091093 5.663898e-02 1.208302e-01 14 58408812 58408873 62 - 2.321 2.365 0.148
ENSG00000100575 E011 185.798657 0.0002340511 8.223039e-02 1.630246e-01 14 58408874 58408879 6 - 2.243 2.287 0.148
ENSG00000100575 E012 332.217793 0.0001396831 2.729841e-02 6.660059e-02 14 58408880 58408978 99 - 2.496 2.537 0.137
ENSG00000100575 E013 240.364766 0.0002123543 1.097969e-02 3.111360e-02 14 58408979 58409033 55 - 2.347 2.404 0.191
ENSG00000100575 E014 245.623479 0.0001711033 1.097802e-01 2.052373e-01 14 58409034 58409081 48 - 2.370 2.405 0.117
ENSG00000100575 E015 158.763562 0.0002533727 6.003456e-02 1.266634e-01 14 58409082 58409084 3 - 2.173 2.225 0.174
ENSG00000100575 E016 170.131181 0.0002335896 9.456422e-02 1.822306e-01 14 58409085 58409099 15 - 2.206 2.251 0.149
ENSG00000100575 E017 275.735002 0.0002141534 7.790869e-01 8.579298e-01 14 58409100 58409168 69 - 2.437 2.442 0.017
ENSG00000100575 E018 180.452377 0.0002444380 8.439271e-01 9.028325e-01 14 58410843 58410844 2 - 2.254 2.258 0.015
ENSG00000100575 E019 341.465249 0.0001508198 6.579306e-01 7.671980e-01 14 58410845 58410938 94 - 2.537 2.528 -0.031
ENSG00000100575 E020 295.485673 0.0001575940 1.355917e-03 5.162684e-03 14 58411907 58411971 65 - 2.506 2.440 -0.220
ENSG00000100575 E021 1.771391 0.0078019329 6.631908e-01 7.713103e-01 14 58411972 58412113 142 - 0.483 0.408 -0.389
ENSG00000100575 E022 0.481513 0.0207760107 6.172426e-01 7.351059e-01 14 58423828 58423849 22 - 0.127 0.210 0.873
ENSG00000100575 E023 293.682398 0.0004534662 6.551967e-06 4.541881e-05 14 58424008 58424095 88 - 2.519 2.418 -0.335
ENSG00000100575 E024 270.191014 0.0002076846 1.269400e-06 1.031102e-05 14 58427054 58427242 189 - 2.486 2.380 -0.352
ENSG00000100575 E025 28.363581 0.0007263444 7.890163e-01 8.649325e-01 14 58427392 58427531 140 - 1.480 1.463 -0.061