ENSG00000100564

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000216452 ENSG00000100564 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGH protein_coding protein_coding 37.16187 22.31629 44.25699 4.09226 1.982636 0.9874881 26.046594 17.717701 29.832949 3.3602026 1.170316 0.7513847 0.7108458 0.79266667 0.6750667 -0.11760000 0.01197541 0.01197541 FALSE TRUE
ENST00000559118 ENSG00000100564 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGH protein_coding retained_intron 37.16187 22.31629 44.25699 4.09226 1.982636 0.9874881 5.992526 2.213142 7.914688 0.5834136 1.093158 1.8337539 0.1537750 0.09713333 0.1774667 0.08033333 0.04419263 0.01197541   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100564 E001 0.8491631 0.0163529309 9.791466e-01 9.910213e-01 14 67581955 67582274 320 - 0.253 0.256 0.025
ENSG00000100564 E002 257.5608235 0.0004668498 7.121355e-06 4.894853e-05 14 67589318 67589713 396 - 2.369 2.473 0.347
ENSG00000100564 E003 166.7844583 0.0005896271 9.060361e-02 1.760813e-01 14 67589714 67589754 41 - 2.208 2.259 0.169
ENSG00000100564 E004 163.4023040 0.0004865457 1.466049e-01 2.570654e-01 14 67589755 67589805 51 - 2.203 2.245 0.141
ENSG00000100564 E005 213.8043401 0.0008946540 2.507777e-02 6.203445e-02 14 67589806 67589905 100 - 2.309 2.367 0.193
ENSG00000100564 E006 230.5824443 0.0002120967 7.614010e-01 8.452838e-01 14 67589906 67589992 87 - 2.365 2.373 0.026
ENSG00000100564 E007 189.9107771 0.0003573593 3.264426e-01 4.698824e-01 14 67589993 67590036 44 - 2.297 2.274 -0.078
ENSG00000100564 E008 230.5840835 0.0008176141 1.515728e-01 2.638059e-01 14 67590037 67590111 75 - 2.385 2.349 -0.118
ENSG00000100564 E009 144.7510560 0.0002860812 2.016866e-01 3.282863e-01 14 67590112 67590126 15 - 2.185 2.149 -0.119
ENSG00000100564 E010 188.6436677 0.0003088893 7.495974e-01 8.365082e-01 14 67590127 67590172 46 - 2.278 2.288 0.032
ENSG00000100564 E011 3.5522466 0.0043587711 7.253711e-01 8.186629e-01 14 67591809 67592314 506 - 0.646 0.700 0.228
ENSG00000100564 E012 7.8014113 0.0021621465 8.744135e-01 9.232755e-01 14 67592315 67592403 89 - 0.937 0.956 0.072
ENSG00000100564 E013 5.7698388 0.0028115953 9.239155e-01 9.560904e-01 14 67592404 67592436 33 - 0.832 0.821 -0.044
ENSG00000100564 E014 190.6587120 0.0002585051 6.119254e-01 7.309652e-01 14 67592635 67592715 81 - 2.280 2.294 0.047
ENSG00000100564 E015 89.2030262 0.0003055632 8.815179e-01 9.280887e-01 14 67592716 67592718 3 - 1.961 1.957 -0.014
ENSG00000100564 E016 6.4234567 0.0228372013 1.478118e-01 2.587075e-01 14 67592719 67592776 58 - 0.950 0.734 -0.838
ENSG00000100564 E017 15.3547199 0.0039428000 1.359004e-03 5.173084e-03 14 67593254 67593727 474 - 1.328 1.026 -1.077
ENSG00000100564 E018 4.4705107 0.0035509077 6.738109e-01 7.793938e-01 14 67593728 67593742 15 - 0.759 0.701 -0.240
ENSG00000100564 E019 189.7762556 0.0002175286 9.772964e-01 9.898573e-01 14 67593743 67593813 71 - 2.283 2.284 0.005
ENSG00000100564 E020 125.6486017 0.0002985520 6.524542e-01 7.631632e-01 14 67593814 67593835 22 - 2.111 2.097 -0.046
ENSG00000100564 E021 151.4592008 0.0002184426 2.201756e-01 3.506440e-01 14 67593836 67593909 74 - 2.202 2.168 -0.114
ENSG00000100564 E022 122.7080004 0.0008269008 4.844802e-02 1.064179e-01 14 67593910 67593947 38 - 2.125 2.057 -0.228
ENSG00000100564 E023 79.4177936 0.0003398354 5.015868e-03 1.597420e-02 14 67593948 67593952 5 - 1.955 1.843 -0.376
ENSG00000100564 E024 141.8535623 0.0008187568 1.058972e-02 3.018467e-02 14 67600024 67600286 263 - 2.193 2.110 -0.278