ENSG00000100554

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000216442 ENSG00000100554 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP6V1D protein_coding protein_coding 32.03784 18.4289 46.04538 2.827271 1.551391 1.320617 24.472907 17.18963 32.455561 2.747031 1.018129 0.9165328 0.79843333 0.9312333 0.7062333 -0.2250 3.204731e-10 6.863007e-39 FALSE TRUE
ENST00000554236 ENSG00000100554 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP6V1D protein_coding protein_coding 32.03784 18.4289 46.04538 2.827271 1.551391 1.320617 3.227962 0.00000 6.724877 0.000000 0.103243 9.3955078 0.08044583 0.0000000 0.1465000 0.1465 6.863007e-39 6.863007e-39 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100554 E001 0.1482932 0.0411597534 2.703050e-01   14 67284499 67284545 47 - 0.000 0.159 11.380
ENSG00000100554 E002 0.0000000       14 67294371 67294987 617 -      
ENSG00000100554 E003 0.3697384 0.0248214929 8.239526e-02 1.632899e-01 14 67304012 67304059 48 - 0.000 0.275 12.402
ENSG00000100554 E004 0.1482932 0.0411597534 2.703050e-01   14 67304060 67304077 18 - 0.000 0.159 11.398
ENSG00000100554 E005 0.7437457 0.0156708631 4.556388e-01 5.961490e-01 14 67312005 67312057 53 - 0.292 0.159 -1.117
ENSG00000100554 E006 1.1812384 0.0115611736 9.243030e-01 9.563208e-01 14 67312058 67312086 29 - 0.342 0.366 0.145
ENSG00000100554 E007 1.1865370 0.0119935244 5.177812e-01 6.521111e-01 14 67312087 67312183 97 - 0.387 0.275 -0.702
ENSG00000100554 E008 13.1425049 0.0211645205 4.162020e-05 2.388978e-04 14 67336188 67336646 459 - 1.283 0.736 -2.034
ENSG00000100554 E009 5.2672264 0.0035801840 1.705172e-02 4.505059e-02 14 67336647 67336677 31 - 0.900 0.562 -1.389
ENSG00000100554 E010 6.2302153 0.0287163395 9.393223e-03 2.726437e-02 14 67336678 67336738 61 - 0.972 0.562 -1.659
ENSG00000100554 E011 5.9045198 0.0027563228 1.184183e-01 2.176705e-01 14 67337387 67337509 123 - 0.900 0.697 -0.803
ENSG00000100554 E012 9.3892421 0.0020162781 1.220854e-01 2.229081e-01 14 67337510 67337776 267 - 1.071 0.907 -0.608
ENSG00000100554 E013 35.2978076 0.0007997311 8.586857e-06 5.793491e-05 14 67337872 67338070 199 - 1.437 1.707 0.921
ENSG00000100554 E014 16.5770809 0.0016014924 2.568535e-03 8.968578e-03 14 67338071 67338074 4 - 1.129 1.387 0.910
ENSG00000100554 E015 73.4373737 0.0004082995 1.445518e-11 2.933258e-10 14 67338075 67338152 78 - 1.738 2.024 0.964
ENSG00000100554 E016 166.4875555 0.0037607433 9.651796e-10 1.435359e-08 14 67338153 67338250 98 - 2.103 2.355 0.844
ENSG00000100554 E017 309.6824707 0.0024369049 4.940596e-04 2.137431e-03 14 67338251 67338498 248 - 2.440 2.553 0.374
ENSG00000100554 E018 141.7215803 0.0002621765 5.056249e-01 6.413761e-01 14 67338499 67338554 56 - 2.140 2.169 0.098
ENSG00000100554 E019 99.0371153 0.0003480104 2.132912e-01 3.424151e-01 14 67338555 67338560 6 - 1.974 2.028 0.181
ENSG00000100554 E020 274.6177024 0.0019803353 7.997379e-01 8.722743e-01 14 67338561 67338762 202 - 2.437 2.432 -0.017
ENSG00000100554 E021 195.8474286 0.0002607734 9.184802e-01 9.524738e-01 14 67340440 67340518 79 - 2.287 2.298 0.039
ENSG00000100554 E022 163.2015547 0.0012995836 4.119833e-01 5.555375e-01 14 67343372 67343438 67 - 2.198 2.229 0.104
ENSG00000100554 E023 226.3001939 0.0025830699 2.098931e-01 3.384137e-01 14 67345768 67345871 104 - 2.366 2.324 -0.138
ENSG00000100554 E024 180.6952668 0.0036447572 7.362357e-02 1.493305e-01 14 67347409 67347453 45 - 2.279 2.207 -0.239
ENSG00000100554 E025 0.5546650 0.0221969388 2.762850e-01 4.157244e-01 14 67348855 67349036 182 - 0.093 0.276 1.887
ENSG00000100554 E026 208.1887849 0.0003347745 3.683626e-02 8.515789e-02 14 67349037 67349104 68 - 2.333 2.287 -0.153
ENSG00000100554 E027 132.9174431 0.0002278906 1.202312e-01 2.203267e-01 14 67350611 67350617 7 - 2.138 2.099 -0.132
ENSG00000100554 E028 138.3504121 0.0002214345 2.275273e-01 3.594440e-01 14 67350618 67350631 14 - 2.152 2.124 -0.092
ENSG00000100554 E029 183.5710524 0.0002017327 8.875089e-02 1.732067e-01 14 67350632 67350690 59 - 2.276 2.240 -0.120
ENSG00000100554 E030 0.1817044 0.0434009447 2.666515e-01   14 67352731 67352922 192 - 0.000 0.159 11.402
ENSG00000100554 E031 243.5027217 0.0002736448 1.715126e-05 1.080097e-04 14 67352923 67353040 118 - 2.418 2.325 -0.310
ENSG00000100554 E032 0.7383334 0.5039873817 8.739603e-01 9.229998e-01 14 67353699 67353959 261 - 0.235 0.266 0.238
ENSG00000100554 E033 193.6204002 0.0002215899 5.337302e-08 5.718448e-07 14 67359658 67359860 203 - 2.334 2.198 -0.452
ENSG00000100554 E034 2.8621773 0.0180465607 6.397797e-02 1.333146e-01 14 67359963 67360063 101 - 0.684 0.366 -1.534
ENSG00000100554 E035 2.1830508 0.0243864640 8.970217e-02 1.746717e-01 14 67360064 67360105 42 - 0.588 0.276 -1.698
ENSG00000100554 E036 3.2128755 0.0050414998 3.039124e-02 7.272913e-02 14 67360106 67360209 104 - 0.725 0.367 -1.700
ENSG00000100554 E037 3.2870572 0.2488997665 5.759132e-01 7.014325e-01 14 67360210 67360313 104 - 0.662 0.523 -0.621