ENSG00000100523

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357758 ENSG00000100523 HEK293_OSMI2_2hA HEK293_TMG_2hB DDHD1 protein_coding protein_coding 5.356767 2.140008 8.553053 0.06843786 0.2532662 1.993783 1.3825879 0.7871123 2.578759 0.042226542 0.04728436 1.699406 0.2254208 0.3687333 0.3022333 -0.0665000 4.339043e-01 2.306399e-24 FALSE TRUE
ENST00000612692 ENSG00000100523 HEK293_OSMI2_2hA HEK293_TMG_2hB DDHD1 protein_coding protein_coding 5.356767 2.140008 8.553053 0.06843786 0.2532662 1.993783 0.3529728 0.5702347 0.000000 0.003338726 0.00000000 -5.858565 0.0986250 0.2669667 0.0000000 -0.2669667 2.306399e-24 2.306399e-24 FALSE TRUE
ENST00000673822 ENSG00000100523 HEK293_OSMI2_2hA HEK293_TMG_2hB DDHD1 protein_coding protein_coding 5.356767 2.140008 8.553053 0.06843786 0.2532662 1.993783 0.6832360 0.0000000 1.214698 0.000000000 0.06024146 6.936282 0.1850333 0.0000000 0.1422667 0.1422667 1.541459e-08 2.306399e-24 FALSE TRUE
MSTRG.9564.12 ENSG00000100523 HEK293_OSMI2_2hA HEK293_TMG_2hB DDHD1 protein_coding   5.356767 2.140008 8.553053 0.06843786 0.2532662 1.993783 1.4526635 0.3577030 1.763419 0.178920049 0.28710125 2.269920 0.2376500 0.1628000 0.2071000 0.0443000 7.968683e-01 2.306399e-24 FALSE TRUE
MSTRG.9564.9 ENSG00000100523 HEK293_OSMI2_2hA HEK293_TMG_2hB DDHD1 protein_coding   5.356767 2.140008 8.553053 0.06843786 0.2532662 1.993783 0.7983567 0.2651794 2.292003 0.157972156 0.38652707 3.064446 0.1270333 0.1288667 0.2660333 0.1371667 4.686162e-01 2.306399e-24 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100523 E001 0.0000000       14 53036745 53036754 10 -      
ENSG00000100523 E002 162.3121122 0.0002790184 3.729280e-11 7.067129e-10 14 53036755 53043967 7213 - 2.109 2.297 0.629
ENSG00000100523 E003 12.7821993 0.0256742916 5.075624e-04 2.188491e-03 14 53043968 53044121 154 - 0.942 1.363 1.511
ENSG00000100523 E004 146.4134205 0.0035980464 1.076578e-01 2.020811e-01 14 53044122 53046026 1905 - 2.110 2.181 0.238
ENSG00000100523 E005 12.0162743 0.0014720217 2.914027e-08 3.287795e-07 14 53046027 53046197 171 - 0.845 1.380 1.939
ENSG00000100523 E006 32.8556240 0.0006247522 3.194555e-04 1.458767e-03 14 53046198 53046432 235 - 1.411 1.640 0.786
ENSG00000100523 E007 20.8392349 0.0009530729 5.696210e-01 6.961544e-01 14 53046433 53046447 15 - 1.287 1.339 0.179
ENSG00000100523 E008 38.3237198 0.0051909832 2.003709e-01 3.266809e-01 14 53046448 53046602 155 - 1.530 1.623 0.315
ENSG00000100523 E009 25.5122139 0.0040440645 1.723145e-01 2.912217e-01 14 53046603 53046684 82 - 1.352 1.461 0.379
ENSG00000100523 E010 43.5096105 0.0006110393 7.844535e-01 8.617258e-01 14 53046685 53046790 106 - 1.603 1.624 0.072
ENSG00000100523 E011 52.6644368 0.0004720216 8.912517e-01 9.345334e-01 14 53046791 53046949 159 - 1.693 1.692 -0.006
ENSG00000100523 E012 1.8080244 0.0399011147 4.820144e-01 6.201734e-01 14 53048548 53049033 486 - 0.372 0.505 0.699
ENSG00000100523 E013 29.5255524 0.0036848357 1.048901e-01 1.979333e-01 14 53051844 53051927 84 - 1.486 1.369 -0.404
ENSG00000100523 E014 1.1749974 0.0175257756 3.448484e-01 4.889455e-01 14 53052510 53053006 497 - 0.372 0.189 -1.307
ENSG00000100523 E015 4.7984069 0.0034140171 4.033291e-01 5.471069e-01 14 53053007 53054437 1431 - 0.687 0.811 0.501
ENSG00000100523 E016 53.1288075 0.0004153493 3.561981e-02 8.284614e-02 14 53054438 53054629 192 - 1.726 1.618 -0.367
ENSG00000100523 E017 60.0925850 0.0003926837 1.728922e-02 4.558397e-02 14 53055660 53055912 253 - 1.778 1.662 -0.394
ENSG00000100523 E018 32.9044301 0.0006845503 2.454569e-01 3.805823e-01 14 53058477 53058626 150 - 1.510 1.436 -0.253
ENSG00000100523 E019 26.8913079 0.0028411165 3.256634e-01 4.691101e-01 14 53061126 53061201 76 - 1.430 1.360 -0.243
ENSG00000100523 E020 0.3686942 0.0307108938 4.511383e-01 5.921255e-01 14 53061202 53061324 123 - 0.077 0.190 1.504
ENSG00000100523 E021 45.9452924 0.0007812520 6.450893e-01 7.572777e-01 14 53062943 53063141 199 - 1.639 1.618 -0.070
ENSG00000100523 E022 28.4562101 0.0007441512 5.841774e-01 7.081653e-01 14 53063142 53063205 64 - 1.417 1.461 0.151
ENSG00000100523 E023 36.4782748 0.0010068460 4.256196e-01 5.685419e-01 14 53072597 53072703 107 - 1.547 1.501 -0.159
ENSG00000100523 E024 37.0873301 0.0034904265 4.627557e-01 6.026099e-01 14 53073741 53073847 107 - 1.554 1.508 -0.157
ENSG00000100523 E025 40.9289061 0.0005897265 1.155018e-01 2.135694e-01 14 53091785 53091910 126 - 1.607 1.515 -0.313
ENSG00000100523 E026 23.1855267 0.0007876893 7.934546e-03 2.361366e-02 14 53091911 53091932 22 - 1.401 1.183 -0.764
ENSG00000100523 E027 0.0000000       14 53091933 53092472 540 -      
ENSG00000100523 E028 0.0000000       14 53092473 53092675 203 -      
ENSG00000100523 E029 0.1482932 0.0412821903 1.684437e-01   14 53092676 53093315 640 - 0.000 0.189 11.578
ENSG00000100523 E030 16.9984864 0.0010579522 2.152667e-02 5.469714e-02 14 53093316 53093321 6 - 1.274 1.057 -0.775
ENSG00000100523 E031 29.1218383 0.0007056995 5.070818e-04 2.186727e-03 14 53093322 53093444 123 - 1.504 1.241 -0.914
ENSG00000100523 E032 1.1854928 0.0164921363 3.446747e-01 4.887654e-01 14 53093445 53093851 407 - 0.372 0.189 -1.308
ENSG00000100523 E033 3.7899062 0.0168043326 9.139731e-02 1.773128e-01 14 53096117 53096166 50 - 0.721 0.422 -1.375
ENSG00000100523 E034 3.4512872 0.0045900621 1.227843e-01 2.239337e-01 14 53096167 53096218 52 - 0.687 0.422 -1.237
ENSG00000100523 E035 0.7406253 0.0154620118 1.675854e-01 2.850522e-01 14 53103031 53103051 21 - 0.294 0.000 -11.629
ENSG00000100523 E036 0.4418608 0.0279131760 3.992578e-01 5.429957e-01 14 53103299 53103682 384 - 0.199 0.000 -10.902
ENSG00000100523 E037 33.5535966 0.0007004807 3.363912e-02 7.904056e-02 14 53103683 53103856 174 - 1.540 1.399 -0.483
ENSG00000100523 E038 0.0000000       14 53103857 53104146 290 -      
ENSG00000100523 E039 0.0000000       14 53149785 53150086 302 -      
ENSG00000100523 E040 21.5240329 0.0028967709 1.298557e-03 4.971589e-03 14 53152261 53152318 58 - 1.387 1.097 -1.026
ENSG00000100523 E041 35.1437986 0.0007482967 1.912224e-06 1.493631e-05 14 53152319 53152705 387 - 1.599 1.255 -1.188
ENSG00000100523 E042 20.3082526 0.0012256657 4.486916e-04 1.961946e-03 14 53152706 53153323 618 - 1.363 1.036 -1.161