ENSG00000100504

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000216392 ENSG00000100504 HEK293_OSMI2_2hA HEK293_TMG_2hB PYGL protein_coding protein_coding 123.9956 107.4503 170.6864 8.015567 4.427753 0.667628 83.31077 70.1915006 120.08031 0.8111212 2.0018943 0.7745460 0.66762083 0.659133333 0.7041667 0.04503333 0.692552911 0.005031198 FALSE TRUE
ENST00000530336 ENSG00000100504 HEK293_OSMI2_2hA HEK293_TMG_2hB PYGL protein_coding retained_intron 123.9956 107.4503 170.6864 8.015567 4.427753 0.667628 23.83248 23.8072942 27.68723 4.3196628 0.9123676 0.2177323 0.19836250 0.218666667 0.1622000 -0.05646667 0.218072368 0.005031198 FALSE TRUE
MSTRG.9511.11 ENSG00000100504 HEK293_OSMI2_2hA HEK293_TMG_2hB PYGL protein_coding   123.9956 107.4503 170.6864 8.015567 4.427753 0.667628 3.98947 0.1695728 9.63362 0.1695728 1.4210880 5.7469339 0.02664167 0.001733333 0.0561000 0.05436667 0.005031198 0.005031198 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100504 E001 0.4396707 2.730084e-02 1.464802e-01 2.568967e-01 14 50857891 50858169 279 - 0.263 0.000 -10.728
ENSG00000100504 E002 4.7421326 4.885667e-02 4.763532e-01 6.149778e-01 14 50905207 50905216 10 - 0.817 0.710 -0.430
ENSG00000100504 E003 5.4084574 4.262445e-02 9.574754e-01 9.773424e-01 14 50905217 50905217 1 - 0.817 0.821 0.015
ENSG00000100504 E004 12.1181319 1.471222e-03 2.485854e-01 3.842569e-01 14 50905218 50905221 4 - 1.173 1.067 -0.382
ENSG00000100504 E005 1220.4366113 4.188967e-04 4.763795e-29 7.391373e-27 14 50905222 50905556 335 - 3.008 3.164 0.518
ENSG00000100504 E006 4.8663541 3.353830e-03 4.407015e-05 2.516566e-04 14 50908142 50908270 129 - 0.957 0.331 -2.816
ENSG00000100504 E007 730.8753344 7.049341e-04 1.604433e-14 5.136110e-13 14 50908271 50908337 67 - 2.793 2.935 0.471
ENSG00000100504 E008 1092.0605464 6.100971e-04 1.610785e-21 1.219658e-19 14 50908821 50908955 135 - 2.962 3.114 0.504
ENSG00000100504 E009 1434.0186673 6.717953e-05 8.718992e-28 1.212766e-25 14 50909895 50910102 208 - 3.104 3.213 0.363
ENSG00000100504 E010 1091.0069723 7.308777e-05 1.534789e-08 1.827193e-07 14 50911730 50911871 142 - 3.008 3.074 0.219
ENSG00000100504 E011 736.6617672 8.913901e-05 4.004293e-04 1.776043e-03 14 50911978 50912036 59 - 2.845 2.896 0.170
ENSG00000100504 E012 793.8449392 9.614495e-05 1.079142e-02 3.066633e-02 14 50912156 50912222 67 - 2.885 2.922 0.122
ENSG00000100504 E013 747.9827574 3.641246e-04 6.045752e-01 7.250556e-01 14 50912223 50912303 81 - 2.871 2.881 0.034
ENSG00000100504 E014 762.0496882 5.960194e-04 5.602404e-01 6.882464e-01 14 50913029 50913130 102 - 2.888 2.878 -0.031
ENSG00000100504 E015 766.3052384 1.991109e-04 1.393261e-01 2.471249e-01 14 50914701 50914815 115 - 2.894 2.876 -0.062
ENSG00000100504 E016 0.1515154 4.271166e-02 6.547826e-01   14 50915190 50915335 146 - 0.107 0.000 -9.141
ENSG00000100504 E017 841.3995059 3.168644e-04 6.697733e-03 2.043986e-02 14 50915336 50915499 164 - 2.943 2.905 -0.127
ENSG00000100504 E018 656.7636342 3.686671e-03 1.365237e-01 2.432184e-01 14 50915825 50915971 147 - 2.839 2.789 -0.166
ENSG00000100504 E019 595.5250470 3.071258e-03 4.683515e-03 1.505034e-02 14 50916642 50916734 93 - 2.814 2.725 -0.296
ENSG00000100504 E020 517.2549683 2.144244e-03 1.391589e-04 6.998656e-04 14 50916962 50917015 54 - 2.760 2.654 -0.355
ENSG00000100504 E021 606.7055953 1.102701e-03 7.179750e-07 6.152109e-06 14 50917016 50917105 90 - 2.830 2.723 -0.358
ENSG00000100504 E022 582.2126654 1.024254e-03 2.543198e-07 2.388820e-06 14 50920541 50920623 83 - 2.813 2.703 -0.367
ENSG00000100504 E023 647.9922915 2.417522e-04 2.182558e-11 4.302591e-10 14 50920956 50921067 112 - 2.857 2.754 -0.343
ENSG00000100504 E024 26.1089936 1.276405e-02 1.593187e-06 1.266095e-05 14 50921068 50921528 461 - 1.582 1.136 -1.554
ENSG00000100504 E025 341.8194297 7.407692e-03 9.853982e-08 1.001775e-06 14 50923237 50923659 423 - 2.397 2.655 0.858
ENSG00000100504 E026 360.1946459 1.250295e-02 4.225735e-02 9.519624e-02 14 50923660 50923932 273 - 2.493 2.623 0.431
ENSG00000100504 E027 207.2837052 1.471720e-02 4.844697e-01 6.224658e-01 14 50923933 50923968 36 - 2.333 2.306 -0.093
ENSG00000100504 E028 1025.9236206 3.635410e-04 1.785275e-10 3.016544e-09 14 50923969 50924100 132 - 3.052 2.965 -0.289
ENSG00000100504 E029 894.1483804 1.965871e-04 1.672435e-14 5.341165e-13 14 50931673 50931776 104 - 2.998 2.898 -0.332
ENSG00000100504 E030 768.4962122 1.309764e-04 9.157338e-17 3.964420e-15 14 50935107 50935185 79 - 2.937 2.826 -0.369
ENSG00000100504 E031 683.7266389 1.158132e-04 9.439665e-14 2.694465e-12 14 50937736 50937837 102 - 2.883 2.780 -0.343
ENSG00000100504 E032 5.4122152 4.610276e-03 3.000350e-01 4.416578e-01 14 50941047 50941107 61 - 0.736 0.874 0.544
ENSG00000100504 E033 789.8848795 7.138531e-04 2.104309e-14 6.602436e-13 14 50944161 50944442 282 - 2.957 2.821 -0.454
ENSG00000100504 E034 161.9978588 2.864146e-03 1.079058e-02 3.066484e-02 14 50944443 50944483 41 - 2.255 2.157 -0.330
ENSG00000100504 E035 0.8502072 1.448428e-02 4.332317e-01 5.756339e-01 14 50944884 50944910 27 - 0.192 0.331 1.041