ENSG00000100503

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000382043 ENSG00000100503 HEK293_OSMI2_2hA HEK293_TMG_2hB NIN protein_coding protein_coding 10.93422 5.974501 15.22586 0.8189315 0.7734821 1.348168 1.8699547 0.8826176 1.55533296 0.1806378 0.77874871 0.8103554 0.15544583 0.1463333 0.105300000 -0.04103333 7.895892e-01 2.725551e-08 FALSE TRUE
ENST00000389869 ENSG00000100503 HEK293_OSMI2_2hA HEK293_TMG_2hB NIN protein_coding protein_coding 10.93422 5.974501 15.22586 0.8189315 0.7734821 1.348168 0.8115756 0.7246693 1.05350365 0.2287804 0.56324125 0.5336581 0.09341250 0.1189667 0.066000000 -0.05296667 7.158811e-01 2.725551e-08 FALSE TRUE
ENST00000486200 ENSG00000100503 HEK293_OSMI2_2hA HEK293_TMG_2hB NIN protein_coding processed_transcript 10.93422 5.974501 15.22586 0.8189315 0.7734821 1.348168 0.6974610 1.1941491 0.80661004 0.2431076 0.40627626 -0.5602948 0.09051250 0.1984000 0.050466667 -0.14793333 3.036186e-01 2.725551e-08 FALSE FALSE
ENST00000530997 ENSG00000100503 HEK293_OSMI2_2hA HEK293_TMG_2hB NIN protein_coding protein_coding 10.93422 5.974501 15.22586 0.8189315 0.7734821 1.348168 5.1576898 1.8264644 7.87782033 0.1616118 0.25393383 2.1026958 0.44451250 0.3097667 0.521566667 0.21180000 6.138026e-03 2.725551e-08 FALSE TRUE
ENST00000673657 ENSG00000100503 HEK293_OSMI2_2hA HEK293_TMG_2hB NIN protein_coding nonsense_mediated_decay 10.93422 5.974501 15.22586 0.8189315 0.7734821 1.348168 0.3129265 0.6702170 0.03142544 0.1189263 0.03142544 -4.0374061 0.04366667 0.1204333 0.001966667 -0.11846667 2.244012e-05 2.725551e-08 TRUE TRUE
MSTRG.9502.15 ENSG00000100503 HEK293_OSMI2_2hA HEK293_TMG_2hB NIN protein_coding   10.93422 5.974501 15.22586 0.8189315 0.7734821 1.348168 0.5187893 0.0000000 1.03404949 0.0000000 0.14445464 6.7060463 0.03737500 0.0000000 0.068033333 0.06803333 2.725551e-08 2.725551e-08 FALSE TRUE
MSTRG.9502.8 ENSG00000100503 HEK293_OSMI2_2hA HEK293_TMG_2hB NIN protein_coding   10.93422 5.974501 15.22586 0.8189315 0.7734821 1.348168 0.6447217 0.0000000 1.51457159 0.0000000 0.60445893 7.2522601 0.04137917 0.0000000 0.096833333 0.09683333 5.827783e-05 2.725551e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100503 E001 0.8083770 0.1058753579 1.400005e-01 2.480231e-01 14 50719763 50719816 54 - 0.140 0.425 2.123
ENSG00000100503 E002 2.7198430 0.1350455433 9.470899e-02 1.824449e-01 14 50719817 50719838 22 - 0.402 0.743 1.575
ENSG00000100503 E003 157.7711079 0.0230671780 2.493020e-06 1.899983e-05 14 50719839 50720472 634 - 2.009 2.395 1.293
ENSG00000100503 E004 92.6598624 0.0086423602 2.074323e-04 9.957539e-04 14 50720473 50720892 420 - 1.849 2.084 0.789
ENSG00000100503 E005 322.3966921 0.0043841908 2.704740e-01 4.091416e-01 14 50720893 50723380 2488 - 2.473 2.454 -0.064
ENSG00000100503 E006 21.1183807 0.0010733893 3.301997e-04 1.501568e-03 14 50723381 50723417 37 - 1.378 1.063 -1.117
ENSG00000100503 E007 22.4263538 0.0034218900 6.462145e-03 1.982533e-02 14 50723418 50723450 33 - 1.385 1.156 -0.803
ENSG00000100503 E008 65.7606242 0.0014448326 4.116595e-06 2.984602e-05 14 50723451 50723672 222 - 1.842 1.607 -0.796
ENSG00000100503 E009 2.0542608 0.0442487310 1.636315e-01 2.798647e-01 14 50725827 50725827 1 - 0.368 0.636 1.317
ENSG00000100503 E010 2.7906171 0.0054876811 2.206478e-02 5.581663e-02 14 50725828 50725832 5 - 0.402 0.778 1.713
ENSG00000100503 E011 3.0840829 0.0050740640 1.674372e-02 4.437422e-02 14 50725833 50725839 7 - 0.434 0.816 1.694
ENSG00000100503 E012 17.3649954 0.0032715217 4.662118e-15 1.610841e-13 14 50725840 50725952 113 - 0.896 1.582 2.439
ENSG00000100503 E013 71.1294160 0.0096666316 3.643350e-02 8.440881e-02 14 50725953 50726066 114 - 1.766 1.920 0.519
ENSG00000100503 E014 2.5841386 0.0058233701 3.991091e-01 5.428456e-01 14 50726067 50726414 348 - 0.565 0.426 -0.680
ENSG00000100503 E015 5.8112122 0.0028483371 5.754443e-04 2.442283e-03 14 50727236 50727578 343 - 0.608 1.063 1.791
ENSG00000100503 E016 6.9709808 0.0029745305 8.807676e-04 3.546716e-03 14 50727579 50727688 110 - 0.682 1.103 1.615
ENSG00000100503 E017 7.5664228 0.0022750062 6.257672e-02 1.309898e-01 14 50727689 50727751 63 - 0.802 1.042 0.906
ENSG00000100503 E018 96.3050677 0.0036023819 6.225975e-08 6.584192e-07 14 50729523 50729723 201 - 1.850 2.118 0.900
ENSG00000100503 E019 0.0000000       14 50730923 50730983 61 -      
ENSG00000100503 E020 66.3037301 0.0039712256 1.435287e-08 1.718345e-07 14 50735516 50735617 102 - 1.670 1.987 1.068
ENSG00000100503 E021 91.6082779 0.0080852591 8.477474e-06 5.725808e-05 14 50738140 50738286 147 - 1.829 2.101 0.913
ENSG00000100503 E022 71.1859299 0.0049658992 2.958705e-04 1.363127e-03 14 50739308 50739371 64 - 1.743 1.959 0.727
ENSG00000100503 E023 77.5040578 0.0003583011 6.685836e-04 2.783456e-03 14 50739372 50739487 116 - 1.799 1.962 0.547
ENSG00000100503 E024 84.0878384 0.0003829376 2.904773e-03 9.983501e-03 14 50741582 50741728 147 - 1.842 1.982 0.473
ENSG00000100503 E025 0.5891098 0.0182535351 2.516419e-01 3.879055e-01 14 50741729 50742385 657 - 0.246 0.000 -12.004
ENSG00000100503 E026 75.4230817 0.0084687637 1.240423e-01 2.257325e-01 14 50743416 50743529 114 - 1.802 1.921 0.404
ENSG00000100503 E027 77.0989906 0.0003867757 1.960895e-03 7.103384e-03 14 50744243 50744365 123 - 1.800 1.951 0.507
ENSG00000100503 E028 79.8045810 0.0021207956 2.387427e-03 8.421608e-03 14 50747992 50748105 114 - 1.813 1.973 0.536
ENSG00000100503 E029 99.2612089 0.0006135698 3.624211e-02 8.404689e-02 14 50752518 50752733 216 - 1.928 2.028 0.335
ENSG00000100503 E030 54.8344297 0.0004335147 9.046448e-01 9.432934e-01 14 50754563 50754632 70 - 1.697 1.722 0.082
ENSG00000100503 E031 56.7814261 0.0043315099 5.498131e-01 6.795037e-01 14 50754742 50754867 126 - 1.723 1.705 -0.062
ENSG00000100503 E032 246.1332786 0.0048489537 2.032326e-05 1.258239e-04 14 50756492 50757787 1296 - 2.390 2.237 -0.512
ENSG00000100503 E033 131.3682763 0.0184197878 1.696517e-03 6.272370e-03 14 50757788 50758630 843 - 2.130 1.927 -0.682
ENSG00000100503 E034 57.8024808 0.0007844861 6.926272e-04 2.872067e-03 14 50759857 50759993 137 - 1.771 1.601 -0.575
ENSG00000100503 E035 113.2352872 0.0002777500 5.077475e-10 7.936571e-09 14 50759994 50760359 366 - 2.072 1.841 -0.777
ENSG00000100503 E036 56.5678985 0.0005408772 1.107410e-04 5.712607e-04 14 50761790 50761911 122 - 1.768 1.570 -0.673
ENSG00000100503 E037 0.1515154 0.0432045784 1.000000e+00   14 50761912 50761972 61 - 0.076 0.000 -10.005
ENSG00000100503 E038 60.9405424 0.0004191126 2.516728e-03 8.813874e-03 14 50763826 50763964 139 - 1.787 1.647 -0.475
ENSG00000100503 E039 39.1944479 0.0039803015 9.598755e-02 1.843529e-01 14 50766307 50766396 90 - 1.590 1.492 -0.336
ENSG00000100503 E040 47.6046487 0.0123385667 9.689638e-03 2.799818e-02 14 50766780 50766890 111 - 1.695 1.501 -0.662
ENSG00000100503 E041 51.1675968 0.0007393686 6.238369e-05 3.431692e-04 14 50770388 50770517 130 - 1.728 1.507 -0.752
ENSG00000100503 E042 34.4064192 0.0005868544 2.754157e-05 1.652782e-04 14 50770518 50770562 45 - 1.575 1.286 -0.998
ENSG00000100503 E043 60.7902981 0.0025819155 1.801426e-06 1.415432e-05 14 50770852 50770992 141 - 1.812 1.543 -0.913
ENSG00000100503 E044 0.1472490 0.0431768920 1.000000e+00   14 50771316 50771331 16 - 0.076 0.000 -10.005
ENSG00000100503 E045 61.5977989 0.0005217204 3.460295e-07 3.161252e-06 14 50771332 50771468 137 - 1.818 1.556 -0.890
ENSG00000100503 E046 0.0000000       14 50771986 50772300 315 -      
ENSG00000100503 E047 62.4835339 0.0004645096 1.963723e-08 2.293739e-07 14 50772301 50772468 168 - 1.828 1.536 -0.993
ENSG00000100503 E048 56.9225612 0.0005035833 4.819045e-04 2.090957e-03 14 50772949 50773095 147 - 1.763 1.589 -0.593
ENSG00000100503 E049 59.5527778 0.0080482168 6.223896e-06 4.336515e-05 14 50776949 50777139 191 - 1.810 1.501 -1.049
ENSG00000100503 E050 37.7358728 0.0005853889 4.781986e-05 2.707244e-04 14 50778765 50778804 40 - 1.609 1.345 -0.910
ENSG00000100503 E051 0.3289534 0.0289530313 4.538594e-01   14 50792046 50792049 4 - 0.076 0.192 1.543
ENSG00000100503 E052 9.2573795 0.0106298061 2.944336e-09 4.001440e-08 14 50792050 50792261 212 - 0.647 1.343 2.617
ENSG00000100503 E053 0.3299976 0.0274424043 4.004239e-02   14 50792460 50792513 54 - 0.000 0.324 13.813
ENSG00000100503 E054 69.6322960 0.0038877171 5.015459e-01 6.376895e-01 14 50792712 50792843 132 - 1.814 1.797 -0.058
ENSG00000100503 E055 42.1420971 0.0037847195 5.037219e-01 6.396876e-01 14 50792844 50792881 38 - 1.579 1.641 0.208
ENSG00000100503 E056 0.6213751 0.0223990315 1.000000e+00 1.000000e+00 14 50794436 50794525 90 - 0.196 0.192 -0.042
ENSG00000100503 E057 0.3030308 0.3937528777 7.865548e-01   14 50805917 50806207 291 - 0.141 0.000 -11.012
ENSG00000100503 E058 0.7782011 0.0161971222 5.136402e-01 6.484277e-01 14 50806208 50806276 69 - 0.196 0.324 0.956
ENSG00000100503 E059 0.2214452 0.0396505986 1.677148e-01   14 50806277 50806736 460 - 0.000 0.192 12.819
ENSG00000100503 E060 49.0409301 0.0004840420 6.861089e-01 7.886926e-01 14 50806737 50806818 82 - 1.648 1.688 0.136
ENSG00000100503 E061 42.2341157 0.0078173579 9.587771e-01 9.781677e-01 14 50821874 50822000 127 - 1.590 1.612 0.074
ENSG00000100503 E062 26.6282672 0.0162204071 7.845601e-01 8.617879e-01 14 50822001 50822077 77 - 1.405 1.396 -0.032
ENSG00000100503 E063 16.8622713 0.0012848840 4.579399e-02 1.016561e-01 14 50830464 50830517 54 - 1.259 1.083 -0.627
ENSG00000100503 E064 0.9211837 0.0133006385 7.097535e-01 8.070432e-01 14 50830518 50830723 206 - 0.246 0.324 0.542
ENSG00000100503 E065 15.2509086 0.0015031801 5.346749e-07 4.702751e-06 14 50831006 50831181 176 - 1.281 0.689 -2.220