ENSG00000100473

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000396618 ENSG00000100473 HEK293_OSMI2_2hA HEK293_TMG_2hB COCH protein_coding protein_coding 27.87236 16.17486 43.85636 1.177108 1.136506 1.438471 13.1637239 9.444471 19.83794 0.3062486 1.1681040 1.069920 0.48532083 0.5880 0.45340000 -0.13460000 1.085010e-01 4.469456e-17 FALSE  
ENST00000644874 ENSG00000100473 HEK293_OSMI2_2hA HEK293_TMG_2hB COCH protein_coding protein_coding 27.87236 16.17486 43.85636 1.177108 1.136506 1.438471 6.9169703 3.967025 11.23328 0.7833184 1.0281675 1.499302 0.25516250 0.2416 0.25660000 0.01500000 9.229442e-01 4.469456e-17 FALSE  
MSTRG.9316.4 ENSG00000100473 HEK293_OSMI2_2hA HEK293_TMG_2hB COCH protein_coding   27.87236 16.17486 43.85636 1.177108 1.136506 1.438471 0.9481211 0.000000 3.25744 0.0000000 0.3661094 8.352017 0.02084583 0.0000 0.07433333 0.07433333 4.469456e-17 4.469456e-17 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100473 E001 0.4418608 0.0271231240 3.128085e-01 4.553431e-01 14 30874373 30874374 2 + 0.215 0.000 -9.414
ENSG00000100473 E002 1.6263069 0.0085363645 9.780162e-01 9.903746e-01 14 30874375 30874513 139 + 0.396 0.397 0.002
ENSG00000100473 E003 1.6951925 0.2692068951 9.657751e-01 9.824749e-01 14 30874514 30874523 10 + 0.396 0.409 0.072
ENSG00000100473 E004 13.6785273 0.0492134093 3.158093e-01 4.585766e-01 14 30874524 30874558 35 + 1.082 1.226 0.516
ENSG00000100473 E005 20.0103537 0.0287966011 4.458288e-01 5.873704e-01 14 30874559 30874571 13 + 1.322 1.235 -0.306
ENSG00000100473 E006 55.7631663 0.0052771632 7.364168e-01 8.269090e-01 14 30874572 30874591 20 + 1.734 1.719 -0.051
ENSG00000100473 E007 44.3583758 0.0028467415 9.247696e-01 9.566274e-01 14 30874592 30874667 76 + 1.629 1.641 0.043
ENSG00000100473 E008 50.9287264 0.0102075758 4.113215e-01 5.548969e-01 14 30874668 30874744 77 + 1.711 1.655 -0.189
ENSG00000100473 E009 39.1905878 0.0181305876 7.579679e-01 8.426378e-01 14 30874745 30874762 18 + 1.592 1.565 -0.094
ENSG00000100473 E010 28.1753078 0.0175579981 4.452923e-01 5.868514e-01 14 30874763 30874763 1 + 1.467 1.402 -0.225
ENSG00000100473 E011 66.0441673 0.0007118883 1.280594e-01 2.314621e-01 14 30874764 30874891 128 + 1.828 1.764 -0.213
ENSG00000100473 E012 40.6186210 0.0021000903 7.306110e-02 1.484296e-01 14 30874892 30874915 24 + 1.633 1.529 -0.356
ENSG00000100473 E013 81.8881447 0.0003530482 1.196299e-03 4.627854e-03 14 30874916 30874972 57 + 1.938 1.807 -0.440
ENSG00000100473 E014 2.4012763 0.0258396906 2.190478e-02 5.548001e-02 14 30874973 30875055 83 + 0.623 0.175 -2.684
ENSG00000100473 E015 74.0806361 0.0003482224 2.479998e-02 6.146527e-02 14 30875056 30875103 48 + 1.884 1.793 -0.307
ENSG00000100473 E016 5.7918042 0.0028327172 1.355576e-02 3.720520e-02 14 30875104 30875298 195 + 0.905 0.542 -1.499
ENSG00000100473 E017 7.9350891 0.0036244529 4.040924e-04 1.790320e-03 14 30875590 30875916 327 + 1.042 0.543 -2.009
ENSG00000100473 E018 4.8068165 0.0294545449 1.056667e-01 1.991091e-01 14 30877336 30877571 236 + 0.816 0.543 -1.151
ENSG00000100473 E019 61.5188157 0.0003994790 3.545175e-02 8.252112e-02 14 30877572 30877573 2 + 1.804 1.709 -0.319
ENSG00000100473 E020 81.2623410 0.0005688641 3.644904e-04 1.636565e-03 14 30877574 30877601 28 + 1.939 1.790 -0.501
ENSG00000100473 E021 163.3347640 0.0016654074 1.298054e-08 1.567020e-07 14 30877602 30877728 127 + 2.252 2.051 -0.673
ENSG00000100473 E022 212.8140242 0.0030492001 6.236174e-09 7.997729e-08 14 30878811 30878944 134 + 2.369 2.154 -0.718
ENSG00000100473 E023 180.1145125 0.0026003561 5.372654e-07 4.723781e-06 14 30879423 30879485 63 + 2.290 2.105 -0.620
ENSG00000100473 E024 170.7659776 0.0002591680 6.648214e-09 8.471677e-08 14 30880452 30880496 45 + 2.262 2.094 -0.561
ENSG00000100473 E025 250.8825111 0.0009501851 2.757041e-05 1.654231e-04 14 30880587 30880734 148 + 2.412 2.303 -0.365
ENSG00000100473 E026 229.2187293 0.0017078633 6.468548e-01 7.586545e-01 14 30884553 30884656 104 + 2.342 2.336 -0.021
ENSG00000100473 E027 4.0541240 0.0547950000 7.488017e-01 8.359256e-01 14 30884910 30884984 75 + 0.704 0.650 -0.227
ENSG00000100473 E028 10.0100271 0.0573572668 2.323454e-01 3.652299e-01 14 30884985 30885041 57 + 1.075 0.876 -0.741
ENSG00000100473 E029 380.6066095 0.0011041284 1.570030e-01 2.711125e-01 14 30885394 30885620 227 + 2.546 2.588 0.141
ENSG00000100473 E030 617.1898899 0.0031111777 2.095426e-04 1.004745e-03 14 30885796 30886312 517 + 2.730 2.838 0.361
ENSG00000100473 E031 261.0463378 0.0005632538 7.042244e-17 3.089699e-15 14 30889616 30889793 178 + 2.317 2.526 0.697
ENSG00000100473 E032 394.7715517 0.0001678307 1.000915e-27 1.384089e-25 14 30889794 30890618 825 + 2.496 2.701 0.681
ENSG00000100473 E033 24.0680305 0.0156487280 7.201461e-06 4.944174e-05 14 30894913 30895567 655 + 1.190 1.618 1.485