ENSG00000100439

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000428304 ENSG00000100439 HEK293_OSMI2_2hA HEK293_TMG_2hB ABHD4 protein_coding protein_coding 8.097426 12.14487 4.36324 0.5880384 0.1773438 -1.47476 5.359542 8.537241 2.380255 0.5345544 0.18767583 -1.838294 0.6444375 0.7077000 0.5440000 -0.1637000 0.177065928 0.001458841 FALSE TRUE
MSTRG.9192.1 ENSG00000100439 HEK293_OSMI2_2hA HEK293_TMG_2hB ABHD4 protein_coding   8.097426 12.14487 4.36324 0.5880384 0.1773438 -1.47476 2.022880 2.759111 1.612624 0.1658616 0.05609358 -0.771094 0.2667417 0.2274667 0.3701333 0.1426667 0.001458841 0.001458841 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100439 E001 7.8061195 0.0021827026 0.1735314125 0.292773987 14 22598228 22598289 62 + 0.975 0.809 -0.634
ENSG00000100439 E002 8.6144078 0.0020350943 0.3450676726 0.489150545 14 22598290 22598293 4 + 0.975 0.864 -0.419
ENSG00000100439 E003 9.6765083 0.0018375057 0.4279706313 0.570779640 14 22598294 22598297 4 + 1.002 0.914 -0.331
ENSG00000100439 E004 9.8979536 0.0018063908 0.4726791571 0.611735299 14 22598298 22598299 2 + 1.002 0.923 -0.296
ENSG00000100439 E005 10.1914194 0.0017880889 0.3835155495 0.527723168 14 22598300 22598303 4 + 1.028 0.932 -0.355
ENSG00000100439 E006 26.8599556 0.0126352675 0.5760564171 0.701548977 14 22598304 22598329 26 + 1.379 1.335 -0.151
ENSG00000100439 E007 0.1472490 0.0431172838 0.1278488400   14 22598330 22598442 113 + 0.205 0.000 -11.303
ENSG00000100439 E008 0.0000000       14 22600119 22600193 75 +      
ENSG00000100439 E009 44.1775311 0.0167274920 0.2722908998 0.411154636 14 22601667 22601755 89 + 1.617 1.537 -0.274
ENSG00000100439 E010 49.3076672 0.0207651264 0.1540797509 0.267214703 14 22603390 22603457 68 + 1.687 1.576 -0.376
ENSG00000100439 E011 36.8030809 0.0052288696 0.0431931130 0.096903304 14 22603458 22603496 39 + 1.584 1.446 -0.475
ENSG00000100439 E012 45.6642076 0.0094837001 0.3596728004 0.503993712 14 22603497 22603587 91 + 1.611 1.552 -0.202
ENSG00000100439 E013 29.0698690 0.0031414655 0.1667459520 0.283958402 14 22603588 22603600 13 + 1.450 1.349 -0.349
ENSG00000100439 E014 65.9605039 0.0004889631 0.1362722164 0.242851709 14 22603601 22603762 162 + 1.775 1.706 -0.231
ENSG00000100439 E015 0.5546650 0.0210636077 0.6441181835 0.756485224 14 22603763 22603924 162 + 0.205 0.131 -0.780
ENSG00000100439 E016 63.8893503 0.0004783505 0.0196915532 0.050833331 14 22603925 22604079 155 + 1.796 1.686 -0.372
ENSG00000100439 E017 0.6955713 0.0174202348 0.2292959268 0.361597914 14 22604080 22604090 11 + 0.344 0.131 -1.780
ENSG00000100439 E018 0.6558305 0.0682446096 0.2425325946 0.377132087 14 22604091 22604256 166 + 0.344 0.131 -1.779
ENSG00000100439 E019 1.2617904 0.1171853542 0.1249400713 0.227037060 14 22605787 22605866 80 + 0.534 0.229 -1.799
ENSG00000100439 E020 57.0301593 0.0004586813 0.0307051350 0.073337650 14 22606422 22606533 112 + 1.743 1.635 -0.366
ENSG00000100439 E021 0.0000000       14 22609627 22609723 97 +      
ENSG00000100439 E022 86.2507380 0.0005771247 0.9981256868 1.000000000 14 22609724 22609910 187 + 1.829 1.835 0.023
ENSG00000100439 E023 244.9582512 0.0048336025 0.2983713116 0.439808827 14 22610859 22611540 682 + 2.249 2.299 0.167
ENSG00000100439 E024 88.5445613 0.0024486181 0.0023745352 0.008382063 14 22611541 22611692 152 + 1.708 1.878 0.574
ENSG00000100439 E025 138.9405195 0.0039825451 0.0003147076 0.001439655 14 22611693 22612003 311 + 1.893 2.074 0.605
ENSG00000100439 E026 111.7521810 0.0036504786 0.0501719955 0.109467562 14 22612004 22612963 960 + 1.862 1.968 0.356