ENSG00000100380

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000216218 ENSG00000100380 HEK293_OSMI2_2hA HEK293_TMG_2hB ST13 protein_coding protein_coding 252.247 201.5004 347.9768 4.426479 7.549794 0.7881787 61.88317 57.603944 85.63929 9.202028 3.9885302 0.5720232 0.23839583 0.28423333 0.2459667 -0.03826667 7.380716e-01 9.322905e-44 FALSE TRUE
ENST00000411695 ENSG00000100380 HEK293_OSMI2_2hA HEK293_TMG_2hB ST13 protein_coding protein_coding 252.247 201.5004 347.9768 4.426479 7.549794 0.7881787 75.43859 58.895044 97.88525 1.601880 5.5194770 0.7328476 0.29854583 0.29230000 0.2810333 -0.01126667 8.280319e-01 9.322905e-44 FALSE FALSE
MSTRG.22173.2 ENSG00000100380 HEK293_OSMI2_2hA HEK293_TMG_2hB ST13 protein_coding   252.247 201.5004 347.9768 4.426479 7.549794 0.7881787 18.72567 18.182872 20.39849 3.880477 2.8201671 0.1657963 0.07740417 0.09010000 0.0584000 -0.03170000 4.677687e-01 9.322905e-44 FALSE TRUE
MSTRG.22173.3 ENSG00000100380 HEK293_OSMI2_2hA HEK293_TMG_2hB ST13 protein_coding   252.247 201.5004 347.9768 4.426479 7.549794 0.7881787 24.13143 8.972825 44.80462 4.517980 3.4151153 2.3187283 0.08950833 0.04543333 0.1289000 0.08346667 6.202045e-01 9.322905e-44 FALSE TRUE
MSTRG.22173.4 ENSG00000100380 HEK293_OSMI2_2hA HEK293_TMG_2hB ST13 protein_coding   252.247 201.5004 347.9768 4.426479 7.549794 0.7881787 24.50305 40.305798 15.43544 2.868645 0.5477862 -1.3841644 0.11479167 0.19963333 0.0444000 -0.15523333 9.322905e-44 9.322905e-44 FALSE TRUE
MSTRG.22173.5 ENSG00000100380 HEK293_OSMI2_2hA HEK293_TMG_2hB ST13 protein_coding   252.247 201.5004 347.9768 4.426479 7.549794 0.7881787 45.36859 15.988810 80.63538 6.462166 4.4982027 2.3336274 0.17234167 0.08060000 0.2321667 0.15156667 1.538849e-01 9.322905e-44 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100380 E001 819.3048831 1.053985e-02 9.595894e-01 9.786162e-01 22 40824535 40825250 716 - 2.920 2.908 -0.041
ENSG00000100380 E002 797.7411342 6.189583e-03 5.581127e-01 6.863982e-01 22 40825251 40825515 265 - 2.921 2.884 -0.124
ENSG00000100380 E003 1466.4383272 5.095230e-03 3.973628e-01 5.411253e-01 22 40825516 40826198 683 - 3.190 3.142 -0.161
ENSG00000100380 E004 2823.6359481 1.553081e-04 5.705331e-34 1.297548e-31 22 40826199 40826659 461 - 3.410 3.494 0.280
ENSG00000100380 E005 1006.0521920 2.695310e-04 3.212522e-09 4.335394e-08 22 40826660 40826666 7 - 2.974 3.034 0.201
ENSG00000100380 E006 1324.7606540 6.477728e-05 3.608129e-32 7.032399e-30 22 40827096 40827149 54 - 3.073 3.175 0.338
ENSG00000100380 E007 1494.7311397 2.092094e-04 3.708606e-20 2.406935e-18 22 40827150 40827220 71 - 3.135 3.219 0.282
ENSG00000100380 E008 886.7469990 1.597636e-04 1.632442e-09 2.326496e-08 22 40827221 40827229 9 - 2.921 2.982 0.202
ENSG00000100380 E009 1389.0698580 6.497992e-05 1.676198e-11 3.364598e-10 22 40829626 40829671 46 - 3.122 3.170 0.161
ENSG00000100380 E010 1013.5326692 4.355564e-04 7.336431e-01 8.248215e-01 22 40829672 40829674 3 - 3.015 3.000 -0.051
ENSG00000100380 E011 1323.8125161 1.707937e-04 2.374490e-03 8.382060e-03 22 40830840 40830874 35 - 3.117 3.132 0.052
ENSG00000100380 E012 1079.3630675 1.477768e-03 6.058368e-01 7.261463e-01 22 40830875 40830878 4 - 3.039 3.029 -0.033
ENSG00000100380 E013 2013.2734673 6.392775e-05 1.496035e-01 2.611366e-01 22 40830879 40830956 78 - 3.321 3.290 -0.104
ENSG00000100380 E014 5.8199143 3.495125e-03 2.171405e-02 5.508237e-02 22 40832087 40832216 130 - 0.957 0.635 -1.281
ENSG00000100380 E015 2015.2362169 5.212195e-05 7.206096e-03 2.176060e-02 22 40832569 40832651 83 - 3.326 3.285 -0.137
ENSG00000100380 E016 1259.7883274 6.271410e-05 1.488340e-01 2.600881e-01 22 40832652 40832671 20 - 3.119 3.085 -0.113
ENSG00000100380 E017 0.8062886 2.278483e-02 2.938210e-01 4.348644e-01 22 40835106 40835176 71 - 0.332 0.136 -1.641
ENSG00000100380 E018 0.1451727 4.335155e-02 6.459602e-01   22 40835393 40835559 167 - 0.110 0.000 -8.162
ENSG00000100380 E019 2294.3608805 1.684940e-04 2.094852e-03 7.517919e-03 22 40835560 40835670 111 - 3.386 3.336 -0.164
ENSG00000100380 E020 2.8955754 5.381033e-03 1.258033e-02 3.492381e-02 22 40835671 40835802 132 - 0.748 0.323 -2.060
ENSG00000100380 E021 1745.4368913 2.314308e-04 2.154660e-02 5.473969e-02 22 40835803 40835887 85 - 3.266 3.220 -0.153
ENSG00000100380 E022 2.1315644 7.231971e-03 1.825606e-01 3.044235e-01 22 40835888 40835949 62 - 0.387 0.596 1.034
ENSG00000100380 E023 1682.7321764 8.466758e-05 5.474225e-02 1.175476e-01 22 40840626 40840692 67 - 3.246 3.208 -0.125
ENSG00000100380 E024 1655.4075812 7.203560e-04 4.798236e-02 1.056069e-01 22 40844839 40844909 71 - 3.245 3.191 -0.179
ENSG00000100380 E025 6.7481110 2.538485e-03 1.255094e-03 4.826915e-03 22 40847970 40848044 75 - 0.676 1.053 1.462
ENSG00000100380 E026 1725.4565337 1.118590e-03 6.813266e-06 4.705175e-05 22 40848294 40848369 76 - 3.285 3.180 -0.351
ENSG00000100380 E027 0.7061804 1.497877e-01 7.530314e-01 8.390898e-01 22 40850173 40850230 58 - 0.198 0.242 0.370
ENSG00000100380 E028 1552.0082527 3.221019e-03 7.972805e-05 4.265770e-04 22 40850823 40850880 58 - 3.253 3.114 -0.462
ENSG00000100380 E029 0.0000000       22 40854538 40854598 61 -      
ENSG00000100380 E030 2030.1973053 5.448179e-03 1.432169e-04 7.175125e-04 22 40856431 40856964 534 - 3.379 3.216 -0.544